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Traditional Chinese medicine active extract with temperance function, and preparation method and application thereof

An extract and active technology, which is applied to the preparation field of cucurbitacin compounds, has the above-mentioned uses, and can solve the problems of large toxic and side effects, harmful alcohol, and inability to be used by patients.

Active Publication Date: 2013-03-20
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxic and side effects of disulfiram and apomorphine are too large, especially the addiction caused by apomorphine, which is even more harmful than alcohol dependence, and most patients cannot use it

Method used

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  • Traditional Chinese medicine active extract with temperance function, and preparation method and application thereof
  • Traditional Chinese medicine active extract with temperance function, and preparation method and application thereof
  • Traditional Chinese medicine active extract with temperance function, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, extraction process

[0023]Grind 100g of melon stems into coarse powder, pass through a 10-mesh sieve, add 1000g of 80% ethanol for extraction, 2 hours / time, extract twice, combine the extracts, filter, dry to 800ml, filter, add ethanol or water to adjust to The concentration of ethanol is 50-60%, and it is made into 1000ml, and the crude product is obtained by filling and sterilizing. Put the crude product on a silica gel column, use petroleum ether solution, chloroform solution, a mixed solution of chloroform and ethyl acetate with a volume ratio of 1:1, a mixed solution of chloroform and ethyl acetate with a volume ratio of 1:3, ethyl acetate, and 95% ethanol , and water was used as the mobile phase for fractional elution, and each fraction was collected and dried. Obtain water part elution phase, chloroform elution phase part, alcohol elution phase part, ethyl acetate elution phase part, chloroform: ethyl acetate 1: 1 elution phase part and chloroform...

experiment example 1

[0025] Experimental Example 1, Extraction of Melon Pedicel Components

[0026] Grind 100g of melon stems into coarse powder, pass through a 10-mesh sieve, add 1000g of 80% ethanol to extract twice, 2 hours each time, extract twice, combine the extracts, filter, dry to 800ml, filter, add ethanol or water Adjust the ethanol concentration to 50-60%, make 1000ml, fill and sterilize to obtain the crude product. Put the crude product on a silica gel column, use petroleum ether solution, chloroform solution, a mixed solution of chloroform and ethyl acetate with a volume ratio of 1:1, a mixed solution of chloroform and ethyl acetate with a volume ratio of 1:3, and ethyl acetate solution, 95% Ethanol solution and water were used as the mobile phase for fractional elution, and the fractions were collected and dried. The water elution phase, chloroform elution phase, alcohol elution phase, ethyl acetate elution phase, chloroform:ethyl acetate 1:1 elution phase and chloroform:ethyl aceta...

experiment example 2

[0027] Experimental Example 2, Screening of Purging Active Elution Phase

[0028] 70 mice were taken, half male and half female, weighing 18-22 g, numbered, weighed, sorted by weight, randomly divided into 7 groups with 10 mice in each group. During the experiment, the first group was given distilled water by intragastric administration, and the second to seventh groups were given water elution phase, alcohol elution phase, ethyl acetate elution phase, chloroform elution phase, chloroform:ethyl acetate 1:1 Elution phase, chloroform: ethyl acetate 1:3 elution phase; after 30 min, each group was given 0.2 ml of ink by intragastric administration, and then the mice were individually placed in a cage lined with filter paper, and the filter paper was changed every 1 h. Continuously observe for 6 hours, record the time when the mice first appeared ink-containing feces, the time for the first loose stool, the number of black stools, loose stools and total stools discharged by the mic...

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Abstract

The invention discloses a traditional Chinese medicine active extract with temperance function, and a preparation method and application thereof. The main active components in the traditional Chinese medicine active extract with temperance function are cucurbitacin compounds, especially cucurbitacin B and cucurbitacin D. The invention also discloses a preparation method of the active extract, andapplication of the active extract in preparing medicines for treating alcoholic psychosis or medicines with temperance function. The active extract can be added by conventional traditional Chinese medicine preparation methods to prepare any clinical preparation after adding various auxiliary materials and carriers required by preparation of different preparation formulations. The active extract disclosed by the invention is a low-toxicity traditional Chinese medicine extract which can be used for effectively treating alcohol dependence and preparing medicines with abstinence function.

Description

technical field [0001] The present invention relates to an extract derived from the stalk of melon, a traditional Chinese medicine, specifically a cucurbitacin compound, which has emetic and laxative effects, can be used for the treatment of alcoholic psychosis and alcohol dependence, and can be used as a drug for abstaining from alcohol. It relates to a preparation method of an extract with the above-mentioned purposes, and belongs to the field of traditional Chinese medicine. Background technique [0002] Alcohol is one of the most widely used addictive substances in the world. Excessive drinking will not only cause physical and psychological damage, but unrestrained drinking can even develop into an addictive behavior called alcohol dependence. Alcohol dependence has become a serious social and medical problem, and it is one of the top ten disabling diseases in the world, which has attracted widespread attention all over the world. Long-term drinking can not only cause d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K36/42A61P25/00A61P25/32
Inventor 陈华昌乔国芬侯云龙李彦冰朱久新夏炎王立波王小丹
Owner HARBIN MEDICAL UNIVERSITY
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