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Preparation method of isorhynchophylline

A technology of isorhynchophylline and uncaria, which is applied in the field of preparation of isorhynchophylline, and achieves the effects of simple operation, short preparation period and large preparation amount

Inactive Publication Date: 2012-01-11
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the proprietary method for preparing isorhynchophylline is rarely disclosed

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  • Preparation method of isorhynchophylline

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Abstract

The invention belongs to the field of natural medicine chemistry, and particularly relates to a preparation method of isorhynchophylline. The method comprises the following steps: 1) crushing an uncaria medicinal material, acidifying the material by 1% hydrochloric acid, performing reflux extraction with 70-80% ethanol for 2-3 times, concentrating and ammonifying the extract to obtain a pH of 9-10, standing and precipitating to obtain a precipitate; 2) separating the precipitate by high speed countercurrent chromatography, performing on-line monitoring by an ultraviolet detector, collecting the object components, performing refrigeration and crystallization to obtain high-purity rhynchophylline. The preparation method of isorhynchophylline of the invention has a simple process, easy operations, a short preparation period, and high product purity, and is applicable to continuous production.

Description

technical field technical field [0001] The invention belongs to the field of natural medicine chemistry, and in particular relates to a preparation method of isorhynchophylline. Background technique [0002] Isorhynchophylline is an indole alkaloid with molecular formula C 22 h 28 N 2 o 4 , molecular weight 384.46, melting point 138-139°C, molecular structure: [0003] [0004] Isorhynchophylline is an alkaloid in the Rubiaceae plant Uncaria, which can inhibit peripheral vasoconstriction, reduce vascular resistance, lower blood pressure, and have anti-platelet aggregation and anti-thrombotic effects. Isorhynchophylline and rhynchophylline are isomers, and rhynchophylline can be converted into isorhynchophylline in high-temperature polar liquid. [0005] The existing method for separating isorhynchophylline generally adopts packed column chromatography, such as silica gel, alumina and reverse silica gel. However, the proprietary method for preparing isorhynchophyl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/20
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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