Preparation method of compound medicament for treating diarrhea

Abstract

The invention discloses a preparation method of a compound medicament for treating diarrhea. The compound medicament is a compound preparation prepared from zinc-containing medicinal raw materials and medicinal montmorillonite raw material, wherein the zinc-containing medicinal raw materials comprise zinc gluconate, zinc sulfate, zinc citrate, zinc acetate, zinc chloride, zinc lactate, zinc glycinate, L-lysine zinc and licorzinc; and the zinc-containing medicinal raw materials are mixed uniformly with montmorillonite and auxiliary materials by using an equivalent progressive increment method. The compound medicament plays a role in zinc complement and local treatment, and has good effect compared with interval administration of montmorillonite and zinc.

Description

technical field [0001] The invention relates to a compound preparation prepared from a zinc-containing medicinal raw material and a medicinal montmorillonite raw material, in particular to a preparation method and an optimal ratio of the zinc-containing medicinal raw material and the medicinal montmorillonite raw material. Background technique [0002] Diarrhea is a common disease, frequently-occurring disease. Clinically, montmorillonite preparations are used to treat diarrhea [0003] Montmorillonite has a layered network structure and non-uniform charge distribution, and has a fixed covering ability on the digestive tract mucosa. Viruses, bacteria and the toxins they produce have a fixed inhibitory effect. It also activates blood coagulation factors VII, VII, and XII to locally stop bleeding in the digestive tract. It helps the digestive tract epithelial tissue to regenerate, repair, fix and absorb by strengthening the barrier function of the digestive tract mucosa 1. ...

AI Technical Summary

Problems solved by technology

The usage of the two is inconsistent, the former requires fasting, and the latter requires taking after meals. The time of taking the two is inconsistent and contradictory, which causes inconvenience to the treatment and patients.

Because the two are taken at intervals, zinc is almost completely absorbed at the upper end of the intestine, and zinc ions cannot reach the lesion at the lower end of the intestine, and zinc ions cannot directly contact with the damaged intestinal mucosa, so the curative effect of local treatment cannot be exerted, and only the role of zinc supplementation can be exerted. role, can not play the best curative effect of zinc

Zinc-based montmorillonite, because zinc ions completely enter the interlayer of montmorillonite during the preparation process, zinc ions cannot be quickly replaced into the liquid after taking it, so that zinc cannot be released at the upper end of the intestine where zinc absorbs more, so that zinc can be absorbed The amount of zinc is small, the bioavailability is low, zinc only exerts local effects, and the effect of systemic zinc supplementation is reduced, and the best curative effect of zinc cannot be exerted. At the same time, the proportion of zinc in zinc-based montmorillonite is large. When montmorillonite reaches the therapeutic amount , zinc excess