A kind of orally rapidly disintegrating tablet of Shichangpu volatile oil and its preparation method

A technology of oral fast disintegrating tablets and volatile oil, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of esophagus obstruction, tissue damage, gastric and gastrointestinal bleeding, and slow disintegration, etc. To achieve the effect of reducing irritation, convenient swallowing, convenient transportation and storage

Active Publication Date: 2018-08-31
HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. It is safe to take. Ordinary tablets disintegrate slowly, and in the process of oral administration, it is easy to cause the risk of esophageal obstruction and tissue damage, while irritating drugs such as aspirin, potassium chloride, garlic oil, etc., due to their ingestion in the stomach Excessive local concentration can easily induce gastric and gastrointestinal bleeding

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of orally rapidly disintegrating tablet of Shichangpu volatile oil and its preparation method
  • A kind of orally rapidly disintegrating tablet of Shichangpu volatile oil and its preparation method
  • A kind of orally rapidly disintegrating tablet of Shichangpu volatile oil and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The formula of Shichangpu volatile oil orally disintegrating tablets is as follows:

[0023]

[0024] To prepare, follow these steps:

[0025] 1) Preparation of the β-cyclodextrin inclusion compound of the volatile oil of Acorus calamus: add 5 times the amount of water to the β-cyclodextrin according to the formula ratio and thoroughly grind until the solution becomes a paste, then add the volatile oil of Acorus calamus in the Mix well in a colloid mill, grind into a paste, refrigerate at 4°C for 12 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the β-cyclodextrin inclusion complex of volatile oil of Acorus calamus in white powder form;

[0026] 2) Powder direct tableting: Weigh the β-cyclodextrin inclusion complex of Acorus volatile oil and other components according to the formula ratio, fully mix, pass through a 100-mesh sieve, put the mixed powder into a tablet machine for direct tableting.

Embodiment 2

[0028] The formula of Shichangpu volatile oil orally disintegrating tablets is as follows:

[0029]

[0030] To prepare, follow these steps:

[0031] 1) Preparation of the β-cyclodextrin inclusion compound of the volatile oil of Acorus calamus: add 5 times the amount of water to the β-cyclodextrin according to the formula ratio and thoroughly grind until the solution becomes a paste, then add the volatile oil of Acorus calamus in the Mix well in a colloid mill, grind into a paste, refrigerate at 4°C for 12 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the β-cyclodextrin inclusion complex of volatile oil of Acorus calamus in white powder form;

[0032] 2) Wet granulation and tabletting: Weigh the β-cyclodextrin inclusion compound of Acorus volatile oil and other components according to the formula ratio, mix them well, and pass through a 100-mesh sieve, add an appropriate amount of 60% ethanol to prepare a soft material, pass through ...

Embodiment 3

[0034] The formula of Shichangpu volatile oil orally disintegrating tablets is as follows:

[0035]

[0036]

[0037] To prepare, follow these steps:

[0038] 1) Preparation of the β-cyclodextrin inclusion compound of the volatile oil of Acorus calamus: add 5 times the amount of water to the β-cyclodextrin according to the formula ratio and thoroughly grind until the solution becomes a paste, then add the volatile oil of Acorus calamus in the Mix well in a colloid mill, grind into a paste, refrigerate at 4°C for 12 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the β-cyclodextrin inclusion complex of volatile oil of Acorus calamus in white powder form;

[0039] 2) Wet granulation and tabletting method: fully mix the β-cyclodextrin inclusion compound of Acorus volatile oil and excluding magnesium stearate and 1 / 2 low-substituted hydroxymethylcellulose, and pass through 100 mesh Sieve, add appropriate amount of distilled water to pre...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an orally disintegrating tablet of Shichangpu volatile oil and a preparation method thereof. ‑7% disintegrant, 1‑4% glidant and 0.15‑0.8% lubricant as materials, using β‑cyclodextrin inclusion technology and powder direct compression method or wet granulation tableting method, Orally rapidly disintegrating tablets are compressed by a tablet machine. Compared with the prior art, the present invention mixes the β-cyclodextrin powder wrapped with the volatile oil of Acorus calamus with other auxiliary materials and directly compresses it into an orally disintegrating tablet. After entering the oral cavity, the orally disintegrating tablet is mixed with saliva and taken by the patient Swallowing it can not only cover up the bad smell of the volatile oil of Acorus acorus, but also reduce the irritation to the gastrointestinal tract without affecting the curative effect of the volatile oil of Acorus acorus. For infants and middle-aged and elderly patients, it is easy to swallow, transport and store. There are broad market prospects.

Description

technical field [0001] The invention relates to the technical field of oral solid preparations, in particular to an orally disintegrating tablet of Shichangpu volatile oil and a preparation method thereof. Background technique [0002] Shichangpu is listed as the top grade in "Shen Nong's Materia Medica". It is a traditional aromatic medicine that has the effects of resuscitating phlegm, refreshing and improving intelligence. The main active ingredient is the volatile oil of Shichangpu, including β-asarone, α-asarone and other substances. However, the physical properties of these components are unstable and easily oxidized, resulting in a decrease in the efficacy of the drug. The market dosage form of Shichangpu volatile oil is Shichangpu volatile oil injection, but due to the side effects and high risk of direct injection of this injection into the human body, it has been removed from the shelves. [0003] Orally rapidly disintegrating tablets are new oral solid preparati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/888A61P25/28
Inventor 赵蕊贾桂燕蔡亚平赵辉邵星月
Owner HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap