Combination with anticorrosion activity and cosmetic
A technology of composition and cosmetics, which is applied in the field of cosmetic additives, compositions with antiseptic activity and cosmetics. It can solve the problems of poor antiseptic effect, low physical stability, and limited antibacterial properties of preservatives, and achieve excellent antibacterial activity. Low irritation, low physical and chemical stability
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example 1
[0060]
[0061] [Evaluation of product stability]
[0062] In order to confirm the stability of the above-mentioned cosmetic compositions of Examples 1, 2, 3, and 4, the stability was observed at each temperature for 1 month to evaluate the stability.
[0063]
[0064]
[0065] The results are shown in Table 1. The preservative effect of the preservative-free cosmetic composition produced according to the present invention was confirmed.
[0066] Table 1
[0067]
[0068] * NI: No Increase
[0069] Confirm irritation
[0070] Skin irritation was tested through a sealed patch test, and healthy men and women aged 20 to 40 with no abnormal skin were selected as subjects. The test site was the inner side of the upper arm.
[0071] Irritation test A
[0072] Qinjiao extract, pulsatilla extract, moss extract, and cassia bark extract are composed of 49:49:1:1, and the emulsion contains 0.5% by weight of the above additives,
[0073] Irritation test B
[0074] Qin...
example 2
[0079] Put a certain amount of the above three kinds of test substances into the spot test device, and apply them on the inner side of the upper arm of the subject for 48 hours. Irritation was confirmed based on the degree of erythema and questions to the subjects.
[0080] The detailed method is as follows.
[0081] Application method: closed patch test (upper arm inner side)
[0082] Application amount: 20ul~30ul / chamber(IQ
[0083] Application frequency and period: 24 hours after application, observe for 24 hours after application test.
[0084] Observation of reaction: after 30 minutes and 24 hours of patch test, it was observed according to the terminology of CTFA guidelines.
[0085] judgement standard
[0086] Evaluation Criteria: Modified by Frosch&Kligman and CTFA guidelines
[0087]
[0088] Grading Criteria:
[0089]
[0090] The analysis of results according to the grade of mean score
[0091] level
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