Foxm1 peptides and vaccines containing the same
An immunology and antigen technology, applied in the field of drugs for the treatment and prevention of tumors, can solve problems such as low objective response rate
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[0288] Materials and methods
[0289] cell line
[0290] The HLA-A*2402 positive B-lymphoblastoid cell line TISI was purchased from IHWG Cell and GeneBank (Seattle, WA). African green monkey kidney cell line COS7 was purchased from ATCC.
[0291] Selection of candidates for FOXM1-derived peptides
[0292] Using the binding prediction software "BIMAS" (www-bimas.cit.nih.gov / molbio / hla_bind) (Parker et al. (J Immunol 1994, 152(1): 163-75), Kuzushima et al. (Blood 2001, 98(6):1872-81)) and "NetMHC3.0" (www.cbs.dtu.dk / services / NetMHC / ) (Buus et al. (Tissue Antigens., 62:378-84, 2003), Nielsen et al. al. (Protein Sci., 12:1007-17, 2003, Bioinformatics, 20(9):1388-97, 2004)) predicts FOXM1-derived 9-mer and 10-mer peptides that bind HLA-A*2402 molecules . The peptides were synthesized by Biosynthesis (Lewisville, Texas) following standard solid phase synthesis and purified by reverse phase high performance liquid chromatography (HPLC). The purity (>90%) and identity of the...
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