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Anti-hyperglycemic and/or anti-hyperlipidemic agent comprising material containing avian skin-derived sphingomyelin as active ingredient

An anti-hyperlipidemia and anti-hyperglycemia technology, which is applied in the field of anti-hyperglycemia and/or anti-hyperlipidemia agents, can solve problems related to cost and achieve high safety and cost suppression effects

Inactive Publication Date: 2012-04-18
MARUDAI FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, milk and egg yolks have commodity value in themselves, and there is a cost issue when using them as raw materials

Method used

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  • Anti-hyperglycemic and/or anti-hyperlipidemic agent comprising material containing avian skin-derived sphingomyelin as active ingredient
  • Anti-hyperglycemic and/or anti-hyperlipidemic agent comprising material containing avian skin-derived sphingomyelin as active ingredient
  • Anti-hyperglycemic and/or anti-hyperlipidemic agent comprising material containing avian skin-derived sphingomyelin as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Example 1: Production of sphingomyelin-containing material derived from bird skin

[0129] Take the chicken skin according to the usual method, and store it in a refrigerated freezer until it is supplied to the deoiling process. It is processed into powders of about 8mm according to common methods, and is supplied for deoiling treatment.

[0130]

[0131] The about 8mm minced chicken skin obtained by the above operation is deoiled by special superheated steam. Specifically, the internal pressure of the heating container for deoiling is controlled at 0.1MPa, the temperature is controlled at 105±4°C, and the oxygen concentration is controlled below 0.2%, and hot water at 100°C is sprayed at high speed for 25 minutes on the minced chicken skin. (fine hot water droplets), saturated steam and 117 ° C steam (superheated steam) mixed system for deoiling. In addition, this deoiling process was performed using the hi-LOHS-R continuous manufacturing apparatus (manufactured ...

Embodiment 2

[0155] Example 2: Research on anti-hyperlipidemia effect of highly purified sphingomyelin from chicken skin study

[0156] In order to examine the anti-hyperlipidemic effect of the chicken skin-derived high-purity sphingomyelin-containing substance (hereinafter, sometimes referred to as "chicken skin high SM-containing substance") obtained in Example 1, the following experiments were conducted.

[0157]

[0158] As a feed for ZDF (Zucker Diabetic Fatty) mice (male) used in the experiment, AIN-93M (standard feed for mouse-rat nutritional research published by the National Institute of Nutrition, USA in 1993) was purchased. In addition, AIN-93M containing 0.1% by mass chicken skin high SM content (hereinafter sometimes referred to as "SM-containing AIN-93M") was also purchased by special order (both manufactured by Oriental Yeast Co., Ltd.) .

[0159]

[0160] 7-week-old ZDF male mice (16) were purchased from Charles River Co., Ltd., Japan, and allowed to freely ingest ...

Embodiment 3

[0166] Example 3: Research on the anti-hyperglycemic effect and anti-hyperlipidemia effect of deoiled dried chicken skin 1

[0167] In order to investigate the anti-hyperglycemic and anti-hyperlipidemic effects of the deoiled chicken skin obtained in Example 1, the following experiments were carried out.

[0168]

[0169] Solid feed MF (Oriental Yeast Co., Ltd.) was purchased as feed for Zucker rats (male) used in the experiment. In addition, solid feed MF (hereinafter, sometimes referred to as "deoiled chicken skin MF") containing 1% by mass of the deoiled dried chicken skin powder obtained in Example 1 was also purchased by special order.

[0170]

[0171] 9-week-old Zucker male mice (16) were purchased from Charles River Co., Ltd., Japan, given MF, and fed with free feed and water for 1 week.

[0172] Thereafter, grouping (tested group: 8, control group: 8) made the average body weight equal, gave deoiled chicken skin MF in the tested group, gave MF in the control g...

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Abstract

Disclosed is a sphingomyelin-containing material which can be produced in a large quantity at low cost. Also disclosed is an useful use application of a sphingomyelin-containing material. Specifically disclosed is an anti-hyperglycemic and / or anti-hyperlipidemic agent comprising a material containing a sphingomyelin derived from an avain skin as an active ingredient.

Description

technical field [0001] The present invention relates to an antihyperglycemic and / or antihyperlipidemic agent comprising a sphingomyelin content derived from bird skin as an active ingredient. Background technique [0002] Sphingomyelin is one of the phospholipids that has attracted much attention in modern biosciences as a main component of rafts of lipid microdomains on cell membranes and as a starting point of lipid signal transduction. In particular, rafts function as a site for various signal transductions represented by immune responses, and also as a site for transport of specific substances. Therefore, it is also considered that sphingomyelin may be involved in maintaining the structure of biomembranes and signaling in cells. Substances that are highly relevant to expression of cellular functions such as participation in the conduction system. [0003] For example, as described in Patent Document 1, it is reported that as the mechanism of hyperlipidemia-arteriosclero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/688A61K35/36A61P3/06A61P3/10
CPCA61K31/688A61P3/06A61P3/10
Inventor 杉山雅昭小玉芳郎三明清隆藤野武彦柚木惠太
Owner MARUDAI FOOD
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