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Kidney-health patch for treating chronic renal failure and preparation method thereof

A technology of chronic renal failure and healthy patch, applied in the field of traditional Chinese medicine preparations, can solve the problems of small side effects, no proportioning relationship, affecting drug efficacy and the like

Active Publication Date: 2012-05-30
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but Astragalus is used in a high amount, and astragalus and rhubarb have a precipitation reaction, astragalus and salvia miltiorrhiza may also react. If the dosage of astragalus is small in the compatibility of the preparation, it will affect the efficacy of the medicine. The ratio of traditional Chinese medicine directly affects the curative effect of the preparation. Minimal side effects are crucial

Method used

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  • Kidney-health patch for treating chronic renal failure and preparation method thereof
  • Kidney-health patch for treating chronic renal failure and preparation method thereof
  • Kidney-health patch for treating chronic renal failure and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0091] Shenkang Patch is made from the following raw materials: 1500g rhubarb, 1500g salvia miltiorrhiza, 4500g astragalus, and 1500g safflower.

[0092] The preparation method of the Shenkang patch, after extracting the raw materials rhubarb and salvia miltiorrhiza according to the proportion of the above formula, first alcohol precipitation, detanning, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation; The astragalus and safflower are extracted according to the proportion of the above formula, alcohol precipitation again, water precipitation, alcohol precipitation, water precipitation again, ultrafiltration, concentration and drying to make a patch.

Embodiment 2

[0094] The preparation method of Shenkang patch is: take rhubarb and salvia miltiorrhiza, add 7-12 times the amount of the original medicinal materials for the first time, soak for 30 minutes, boil for 30 minutes, filter, and add water for the second time 7-12 times the original medicinal materials. 12 times the amount, boiled for 30 minutes, filtered, the third time the amount of water added was 7-12 times the original medicinal material, boiled for 30 minutes, filtered, combined three water extracts, concentrated to a relative density of 1.18 to 1.25 at 60 ° C, added 95 % ethanol, until the alcohol content of the medicinal solution is 70%, let it stand for 38-60h, take the supernatant and filter until it is clear, recover the ethanol until the relative density is 1.18-1.25 at 60°C, add 5% gelatin solution, remove tanning, add 95% ethanol, until the alcohol content is 75%, let it stand for 38-60h, take the supernatant, filter and clarify, recover the ethanol until the relative...

Embodiment 3

[0096] The preparation method of Shenkang patch is as follows: take rhubarb and salvia miltiorrhiza, add 10 times the amount of the original medicinal materials for the first time, soak for 30 minutes, boil for 30 minutes, filter, add water for the second time 8 times the amount of the original medicinal materials, Boil for 30 minutes, filter, add 7 times the amount of water for the third time, boil for 30 minutes, filter, combine three water extracts, concentrate to a relative density of 1.20-1.22 at 60°C, add 95% ethanol, to the liquid The alcohol content is 70%, let it stand for 48-60h, take the supernatant and filter until clear, recover the ethanol until the relative density is 1.20-1.22 at 60°C, add 5% gelatin solution, remove tanning, add 95% ethanol, until it contains The alcohol content is 75%, stand still for 48-60h, take the supernatant to filter and clarify, recover the ethanol until the relative density is 1.20-1.22 at 60°C, add water to 4 times the amount of the m...

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Abstract

The invention relates to a kidney-health patch for treating chronic renal failure and a preparation method thereof, and the kidney-health patch is prepared by the following raw material herbs: 1500 g of rheum officinale, 1500 g of salvia, 4500 g of radix astragali, 1500 g of safflower. The preparation method comprises the following steps: extracting raw material herbs of rheum officinale and salvia according to the formula ratios, performing first alcohol precipitation, tannin removal, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation; extracting radix astragali and safflower according to the formula ratios, performing first alcohol precipitation, water precipitation, second alcohol precipitation, water precipitation, concentration, and drying to prepare the patch. The advantages of the invention are that accurate adjustment is performed based on the original ratios; the patch has less side effect, is safe for application, has lasting effect and high bioavailability.

Description

technical field [0001] The invention belongs to traditional Chinese medicine preparations, in particular to a Shenkang patch for treating chronic renal failure and a preparation method thereof. Background technique [0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but Astragalus is used in a high amount, and astragalus and rhubarb have a precipitation reaction, astragalus and salvia miltiorrhiza may also react. If the dosage of astragalus is small in the compatibility of the preparation, it will affect the efficacy of the medicine. The ratio of traditional Chinese medicine directly affects the curative effect of the preparation. Minimal side effects are crucial. Contents of the invention [0003] The o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/70A61P13/12
Inventor 曹凤君吕延英詹芳赵兴王光建王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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