Plant colonic-coated hollow capsule

A hollow capsule, colon-dissolving technology, applied in the directions of capsule delivery, non-active components of polymer compounds, non-active components of oil/fat/wax, etc., can solve problems such as insolubility, and achieve good friability, good safety, The effect of low heavy metal content

Inactive Publication Date: 2012-07-04
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a plant-based colon-soluble hollow capsule whose physical and chemical properties conform to the provisions of the 2010 edition of the "Chinese Pharmacopoeia". The site cannot dissolve or disintegrate within 3 hours, and can only disintegrate or dissolve in the human colon to release the drug in the capsule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The present invention is further described in detail below, and specific embodiments are given.

[0017] 1. Zein powder 30kg, 85% ethanol solution 64-68.5kg, plasticizer castor oil 1.6kg.

[0018] The production equipment is the same as the existing gelatin production of hollow capsules. Pour the zein powder, ethanol solution and plasticizer together into the mixer, stir and dissolve, stir for more than 6 hours, and filter the dissolved liquid with a 200-mesh filter bag after fully dissolving, and store it in a bucket. Adjust the glue concentration, add food coloring tablets of various required colors or / and a certain amount of sunscreen titanium dioxide, etc. according to the needs of users, let it stand to remove air bubbles, and then put it into the capsule production line for dipping, drying, cooling, Demoulding, cutting, fitting, inspection, packaging, need to print after fitting, etc.

[0019] 2. Zein powder 30kg, 75% acetone solution 64-68.5kg, plasticizer trie...

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Abstract

The invention discloses a plant colonic-coated hollow capsule, which is prepared by treating 80-95 percent of zein powder and 5-20 percent of a plasticizer serving as raw materials in a more than or equal to 80 percent ethanol solution or a more than or equal to 70 percent acetone solution with a known process and equipment. The quality of the capsule is accordant with the specifications in the colonic-coated hollow capsule standard of the Chinese Pharmacopoeia of the version 2010, the capsule is not disintegrated in an enteric process, is disintegrated on a colonic part within one hour, and has three years of shelf life.

Description

1. Technical field [0001] The invention relates to a hollow capsule of medicinal excipients, in particular to a hollow vegetable capsule, specifically a hollow capsule that does not allow disintegration in the stomach of the human body, nor does it dissolve or disintegrate in the small intestine of the human body, but only in the colon of the human body. Targeted, plant-based, colon-soluble hollow capsules that dissolve rapidly in the site. 2. Technical background [0002] The hollow capsule (capsule shell) is the main excipient for processing capsules. The 2010 edition of the Chinese Pharmacopoeia stipulates that the colon-soluble hollow capsule means that the capsule shell does not disintegrate in gastric juice for 2 hours, and then cannot dissolve or disintegrate in the small intestine of the human body for 3 hours. , which disintegrates or dissolves in the colonic fluid to release the drug in the capsule. The currently used colon dissolving hollow capsules are made of g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/44A61K9/48
Inventor 刘松林
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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