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Application of rubus parvifolius saponin in preparing anti-fatigue drug

A total saponin and anti-fatigue technology, which can be used in drug combinations, anti-toxins, and pharmaceutical formulations, can solve problems that have not been reported in the literature, and achieve the effects of broadening the application range, meeting various needs, and increasing market value

Active Publication Date: 2012-08-08
ZEIN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After conducting systematic research on the mulberry and combining with the literature, the inventor found that the total saponins of the mulberry are the main material basis of the biological activity of the mulberry, but whether the total saponins of the mulberry has an anti-fatigue effect has not been reported in the literature so far

Method used

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  • Application of rubus parvifolius saponin in preparing anti-fatigue drug
  • Application of rubus parvifolius saponin in preparing anti-fatigue drug
  • Application of rubus parvifolius saponin in preparing anti-fatigue drug

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Embodiment Construction

[0008] In order to make the purpose, technical scheme and advantages of the present invention clearer, the anti-fatigue effect and effect of the total saponins of mulberry berry are described in detail below.

[0009] One, the preparation of the total saponins of Maoberry

[0010] Weigh 2kg of Maoberry medicinal material, add 10 times of water to decoct twice, 1 hour each time, filter, combine the filtrate, centrifuge, take the treated macroporous adsorption resin D101 on the supernatant (weak polarity, Tianjin City Haiguang Chemical Co., Ltd.) column, first washed with 0.1% sodium hydroxide solution until the effluent was colorless, then washed with distilled water until the effluent was neutral, and finally eluted with 40% ethanol solution. The ethanol eluate with a volume fraction of 40% was collected, and evaporated to dryness under reduced pressure to obtain the total saponins of chrysanthemum berry with a purity of 65.72%.

[0011] 2. The anti-fatigue effect of total sa...

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Abstract

The invention discloses an application of rubus parvifolius saponin in preparing an anti-fatigue drug. An animal experimental result shows that the rubus parvifolius saponin has excellent anti-fatigue function, capability of obviously prolonging loaded swimming time of a rat, capability of obviously increasing the activity of lactic dehydrogenase, capabilities of reducing the content of serum lactic acid and urea nitrogen after the rat moves and obviously increasing the content of hepatic glycogen after the rat moves, advantages of low toxicity, small side effect, and the like, and safety in use.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new application of total saponins of mulberry in the field of pharmacy. Background technique [0002] With the development of society, people's pace of work and life is getting faster and faster, and fatigue has become a very common urban disease. Many people are prone to symptoms related to fatigue such as dizziness, headache, vertigo, fatigue, memory loss, blood pressure drop, tachycardia, and depression. Fatigue, as a physiological phenomenon, refers to the inability of the body's physiological process to continue its function at a certain level and / or the inability to maintain a predetermined exercise intensity. If fatigue is not eliminated in time, it will gradually accumulate, eventually leading to abnormal regulation of the body's nervous, endocrine and immune systems, and even organic diseases, becoming an important factor that destroys human physical and mental health. Therefor...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P39/00
Inventor 陈剑鸿夏培元王显凤胡小刚黄明春张宏伟戴青
Owner ZEIN BIOTECHNOLOGY CO LTD
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