Anthraquinone dimer derivative Alterporriol P and preparation method and application thereof

A technology of anthraquinone dimer and derivatives, which is applied in the field of anthraquinone dimer derivative Alterporriol P and its preparation and application, can solve the problems such as no anti-tumor drugs, and achieve obvious growth inhibitory activity and application prospects broad effect

Active Publication Date: 2012-08-15
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on obtaining medicinally valuable anthraquinone dimer derivatives and anti-cell proliferation inhibitory activities from marine fungi, so there is no anti-tumor drug related to this in the market.

Method used

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  • Anthraquinone dimer derivative Alterporriol P and preparation method and application thereof
  • Anthraquinone dimer derivative Alterporriol P and preparation method and application thereof
  • Anthraquinone dimer derivative Alterporriol P and preparation method and application thereof

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Embodiment Construction

[0009] In preparing the compounds of the present invention, the following steps are taken:

[0010] (1) The endophytic fungus Alternaria sp. (ZJ-2008003) derived from the soft coral Sarcophyton sp. in the South China Sea was first cultured in the culture medium, and the culture medium used contained glucose 2.0% (weight percentage, the same below), potato 20.0%, agar 1.5%, coarse sea salt 3.0%, and the rest is water, which is made into a test tube slant during use, and the above-mentioned fungal strains are cultivated at 28°C for 5 days.

[0011] The strain culture medium contains 0.1%-5.0% of glucose (percentage by weight, the same below), 5.0%-40.0% of potato, 0.1%-3.0% of agar, 0.05%-5.0% of coarse sea salt, and the rest is water. It is 15-35°C. The culture time is 3-10 days.

[0012] (2) The fungal strains obtained from the above culture are fermented, and the fermentation medium used contains 2.0% glucose, 20.0% potato, 3.0% coarse sea salt, and the rest is water. The f...

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Abstract

The invention relates to an anthraquinone dimer derivative and a preparation method and application thereof. The preparation method comprises the following steps of: performing strain culture on endophytic fungi Alternaria sp. (ZJ-2008003) from alcyonacea Sarcophyton sp. in South China Sea in a strain culture medium, performing fermentation cultivation in a fermentation medium, filtering the obtained fermentation solution to obtain thalli, and extracting the obtained thalli by using methanol; and concentrating the extract, performing silica-gel column chromatography, Sephadex LH-20 gel column chromatography and high performance liquid chromatography preparation, concentrating the obtained eluate, and thus obtaining red powder, namely the anthraquinone dimer derivative Alterporriol P. The anthraquinone dimer derivative from the marine fungi has a strong effect of resisting cell proliferation of human prostatic cancer PC-3 and human colon cancer HCT-116, and can be used as a cell proliferation inhibitor or an anti-tumor agent; and the raw material can be produced in large scale, so the derivative has a broad application prospect.

Description

technical field [0001] The invention relates to an anthraquinone dimer derivative alterporriol P extracted and separated from marine endophytic fungi, a preparation method thereof and an application as an antitumor drug. Background technique [0002] Recently, with the in-depth research on marine microbial metabolites, some quinone compounds with novel structures and significant activities have been isolated from marine microbial metabolites. biological activity. However, there is no report on obtaining medicinally valuable anthraquinone dimer derivatives and anti-cell proliferation inhibitory activity from marine fungi, so there is no anti-tumor drug related to this in the market. Contents of the invention [0003] The object of the present invention is to provide a kind of anthraquinone dimer derivatives extracted and isolated from the endophytic fungus Alternaria sp. (ZJ-2008003) derived from the soft coral Sarcophyton sp. in the South China Sea and its preparation met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C50/34C12P7/66A61P35/00C12R1/645
Inventor 王长云邵长伦郑彩娟
Owner OCEAN UNIV OF CHINA
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