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Acidic blank pellet core and preparation method thereof

A blank pill core, acidic technology, applied in the directions of pill delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of affecting drug effect, low release, poor release, etc., to improve the degree of release and absorption and utilization. Efficiency, simple process, uniform release effect

Inactive Publication Date: 2012-09-12
上海智同医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] For example, the sustained-release pellet preparation Oberan made of weakly alkaline drug vincamine has obvious pH dependence in its release, and it can be released well under acidic conditions, but it cannot be released under neutral or weakly alkaline conditions. lower release, which leads to poor release in the weakly alkaline intestinal environment, thereby affecting drug efficacy

Method used

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  • Acidic blank pellet core and preparation method thereof
  • Acidic blank pellet core and preparation method thereof
  • Acidic blank pellet core and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Blank ball core 50g

[0027] Tartaric acid 100g

[0028] Take tartaric acid and add 300ml of water to dissolve it to make an organic acid solution. Put the blank core in the fluidized bed, spray it with organic acid solution to cover the surface of the core, take it out after drying, and then get the acidic blank core.

Embodiment 2

[0030] Blank ball core 100g

[0031] Citric acid 50g

[0032] Take citric acid and add 500ml of water to dissolve it to make an organic acid solution. Put the blank core in the fluidized bed, spray it with organic acid solution to cover the surface of the core, take it out after drying, and then get the acidic blank core.

Embodiment 3

[0034] Blank ball core 100g

[0035] Tartaric acid 5g

[0036] Malic acid 5g

[0037] Take tartaric acid and malic acid and add 30ml of water to dissolve to make an organic acid solution. Place the blank pellet core in the extrusion spheronization equipment, spray it with organic acid solution to cover the surface of the pellet core, take it out after drying, and obtain the acidic blank pellet core.

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Abstract

The invention discloses an acidic blank pellet core, which comprises a blank pellet core and an organic acid and is used for substituting a common blank pellet core in a sustained-release pellet preparation. Medicaments can be prepared into the sustained-release pellet preparation which can be stably released under the condition that the pH is 1.5 to 7.4, the release pH dependency of most conventional weakly alkaline medicaments is eliminated, the medicinal preparation can be released in stomach and intestinal tracts stably and slowly, and the medicament effect is lasting. Moreover, the invention also discloses a preparation method for the acidic blank pellet core. The method is simple and convenient, and facilitates industrialized production; and the acidic blank pellet core substitutes the conventional blank pellet core, is used for the sustained-release pellet preparation, can eliminate the release pH dependency of the alkaline medicaments, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a blank core for preparations, in particular to an acidic blank core and a preparation method thereof. Background technique [0002] Pellets refer to all kinds of pills with a diameter of less than 2.5mm, which can be made into quick-release or sustained-release pellets according to different needs. Pellets can be compressed into tablets, and can also be packed in capsule shells to make capsules. In recent years, micropills have been paid more and more attention by people, and have become a major trend in the development of sustained and controlled release preparations. Now many companies at home and abroad all produce this preparation, such as Contac (Contac) sustained-release capsules produced by Sino-US SmithKline, aspirin sustained-release capsules produced by the pharmaceutical factory of China Pharmaceutical University, and imported drugs approved by the ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/12A61J3/06
Inventor 陈挺汤爱斌张继全
Owner 上海智同医药科技有限公司
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