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Method for analyzing and measuring etidronic acid and salts of etidronic acid in sample

A technique for measuring etidronic acid, applied in the field of detection, can solve problems such as unclear end point and difficulty in mastering, and achieve the effects of wide linear range, easy operation and good precision

Active Publication Date: 2012-10-17
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem solved by the present invention is to provide a method for analyzing and determining etidronate and its salts in hair care products and soap products by using ion chromatography-suppressed conductometric detection method, avoiding the USP [9] The end point of the titration method to determine the content of etidronate is not obvious, and it is not easy to grasp the defects. The method is simple, high sensitivity, good selectivity, and the sample pretreatment and mobile phase are mainly made of water, which is environmentally friendly and economical, and has good practical application. value

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  • Method for analyzing and measuring etidronic acid and salts of etidronic acid in sample
  • Method for analyzing and measuring etidronic acid and salts of etidronic acid in sample
  • Method for analyzing and measuring etidronic acid and salts of etidronic acid in sample

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Embodiment Construction

[0020] For further illustrating the present invention, specifically illustrate in conjunction with following examples:

[0021] 1. Experimental process

[0022] 1.1 Instruments and reagents

[0023] DIONEX ICS-3000 ion chromatograph (Dionex, USA), equipped with suppressed conductivity detector, EGCⅡKOH eluent automatic generator and ASRS-400 anion automatic regeneration electrolytic suppressor;

[0024] Milli-Q ultrapure water device (Milli-Q Company, USA); electronic balance (MettlerToledo Company, Switzerland); pH meter (Sartorius Company, Germany); oscillator (Tokyo Rikakikai Company, Japan); OnGuardⅡRP solid-phase extraction column (2.5 mL, USA Dionex Company); 0.22 μm nylon filter membrane.

[0025] The purity of etidronic acid standard (Sigma, USA, CAS No. 25211-86-3) is not less than 95%; 3.0mM hydrochloric acid aqueous solution; 6.0M hydrochloric acid aqueous solution; the experimental water is deionized water (18.2MΩ·cm).

[0026] 1.2 Drawing of quantitative standa...

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Abstract

The invention relates to a method for analyzing and measuring etidronic acid and salts of etidronic acid in a sample. According to the method, the contents of etidronic acid and the salts of etidronic acid in hair care products and soap products are measured by applying an ion chromatography-suppressed conductivity detection method; the pretreatment of the sample is simple and convenient in operation; the method is wide in linear range, good in precision, high in accuracy, rapid and sensitive; water is mainly used as a solution of sample pretreatment and moving phase, so that the method is economical and environment-friendly; and the method has better actual application value and is suitable for daily detection of the hair care products and the soap products.

Description

technical field [0001] The invention relates to a detection method, in particular to a detection method of etidronate and its salts. Background technique [0002] With the rapid development of today's social economy and the rapid improvement of people's living standards, people's pursuit of beauty is also constantly improving, and cosmetics have become an important part of people's colorful modern life. Cosmetics, as essential daily necessities, have attracted more and more attention from the public because they can stay on the skin, hair and other parts for a long time. [0003] Eidronate (HEDP) and its salts are widely used in chemical industry and pharmacy, etidronate disodium is an effective drug for the treatment and prevention of osteoporosis [1] . Eidronate and its salts are used as raw materials for the production of hair care products and soap products to inhibit the formation of free radicals, control the stability and viscosity of emulsifiers, and are widely use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 马强丁岚王超白桦苏宁孟宪双陈云霞
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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