Composite fat-soluable vitamin injection

A technology of fat-soluble vitamins and vitamins, applied in the direction of drug combinations, organic active ingredients, medical preparations of non-active ingredients, etc., to achieve the effect of highlighting substantive characteristics and significant progress

Inactive Publication Date: 2012-10-24
刘时灵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the ingredients contained in fat-soluble vitamins are sticky and difficult to dissolve, especially insoluble in water, K-type vitamins are resistant to heat and water, and are easily oxidized and damaged by light (ultraviolet rays). General additives such as co-solvents cannot help them Dissolved in water to form a clear solution, the antioxidant effect of antioxidants is not satisfactory. Therefore, when fat-soluble vitamins are prepared into injections, the solubility should be improved, no additional excipients should be added, and the stability of oxidized components should be maintained. The stability of the clear solution after placement is an important issue that needs to be solved

Method used

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  • Composite fat-soluable vitamin injection
  • Composite fat-soluable vitamin injection
  • Composite fat-soluable vitamin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] A kind of fat-soluble vitamin injection, its raw material is composed of:

[0098] Vitamin A Palmitate 0.7352g,

[0099] Vitamin D2 0.0025g,

[0100] Vitamin E 7.5g,

[0101] Vitamin K1 1.0g,

[0102] SolutolHs15 65.0g,

[0103] Fat-soluble antioxidants in moderation.

[0104] Preparation methods include:

[0105] (1) Take by weighing 50-80% water for injection of the total dosing volume, and prepare 150-200ml of 95% ethanol solution;

[0106] (2) Add appropriate amount of ethanol to dissolve vitamin D2 and fat-soluble antioxidant, pour into melted Solutol Hs15 and mix well;

[0107] (3) Melt vitamin A palmitate through ultrasound, then add the melted A palmitate, vitamin E, and vitamin K1 to the solution obtained in (2), and stir until it becomes a clear solution;

[0108] (4) Add the water for injection in (1) to the clear solution obtained in (3) at least twice, and mix well; the water for injection is added in a small to large amount and from fast to slow Grad...

Embodiment 2

[0112] A kind of fat-soluble vitamin injection, its raw material is composed of:

[0113] Vitamin A Palmitate 0.65g,

[0114] Vitamin D2 0.002g,

[0115] Vitamin E 7g,

[0116] Vitamin K1 1.0±0.1g,

[0117] Solutol Hs15 65±0.5g,

[0118] Fat-soluble antioxidants in moderation.

[0119] Preparation methods include:

[0120] (1) Take by weighing 50-80% water for injection of the total dosing volume, and prepare 150-200ml of 95% ethanol solution;

[0121] (2) Add appropriate amount of ethanol to dissolve vitamin D2 and fat-soluble antioxidant, pour into melted Solutol Hs15 and mix well;

[0122] (3) Add vitamin A palmitate, vitamin E, and vitamin K1 to the solution of (2), add the remaining amount of ethanol, and stir until clear;

[0123] (4) Add the water for injection of (1) to the clear solution obtained in (3), and mix well;

[0124] (5) adding gac to the solution obtained in (4), then decarburization and filtration;

[0125] (6) Adjust the pH value to 6.3-6.5, then...

Embodiment 3

[0127] A kind of fat-soluble vitamin injection, its raw material is composed of:

[0128] Vitamin A Palmitate 0.85g,

[0129] Vitamin D2 0.003g,

[0130] Vitamin E 8g,

[0131] Vitamin K1 1.0±0.1g,

[0132] SolutolHs15 65±0.5g,

[0133] Fat-soluble antioxidants in moderation.

[0134] The preparation method is the same as in Example 1.

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Abstract

The invention provides composite fat-soluable vitamin injection which is composed of the following raw materials: 0.5-1g of vitamin A palmitate, 0.001-0.005g of vitamin D2, 5-10g of vitamin E, 1.0+/-0.1g of vitamin K1, 50-80g of Solutol Hs 15 and proper amount of fat-soluable antioxygen. The fat-soluable vitamin injection can be totally placed under the normal-temperature and normal environment, can be always kept to be clear within the shelf life of the injection, and has no particles or phenomena of turbidity, layering and other unstable states.

Description

technical field [0001] The invention relates to a vitamin injection and a preparation method thereof, in particular to a fat-soluble vitamin and a preparation method thereof. Background technique [0002] Vitamins are trace amounts of low-molecular-weight organic compounds necessary to maintain the body's life activities. There are many types and different chemical structures. Physiologically, it is neither the main raw material of various tissues nor the source of energy in the body. However, it plays a very important role in the reaction of energy production and in the process of regulating the body's substance metabolism. effect. [0003] According to the solubility, vitamins are divided into two categories: water-soluble and fat-soluble. Fat-soluble vitamins refer to vitamins that are insoluble in water and can be stored in the body after absorption. Fat-soluble vitamins include vitamin A (retinol), vitamin D, vitamin E, and vitamin K. The characteristics of fat-solubl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/592A61K31/355A61K31/232A61K31/122A61K47/34A61K9/08A61P3/02
Inventor 李静李慧
Owner 刘时灵
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