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Cosmetic compostion for preventing skin aging

A cosmetic composition and skin aging technology, which is applied in the direction of cosmetics, cosmetics, cosmetic preparations, etc., can solve the problems that are not known by people, and achieve the effects of excellent activity, excellent skin regeneration ability, and excellent anti-oxidation effect

Inactive Publication Date: 2012-12-19
PUSAN NAT UNIV IND UNIV COOPERATION FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, although medicines and cosmetics using gold nanoparticles have been widely developed, the application of gold nanoparticles surface-treated with phytochemicals such as gallic acid and isoflavones or protocatechuic acid and isoflavones has been widely developed. Cosmetic compositions for the prevention of skin aging are not yet known and have not been studied

Method used

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  • Cosmetic compostion for preventing skin aging
  • Cosmetic compostion for preventing skin aging
  • Cosmetic compostion for preventing skin aging

Examples

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Effect test

preparation example 1

[0034] Preparation Example 1: Preparation of Gold Nanoparticles Surface-treated with Gallic Acid and Isoflavones (GI-Au NPs)

[0035] The inventors of the present application prepared gold nanoparticles by the method described in PCT / KR / 2010 / 007516 already filed. Specifically, chloroauric acid (HAuCl 4 ) (7.8 mg, 0.02 mmol) was dissolved in 20 ml of distilled water, thereby preparing chloroauric acid. Then, a mixed solution in which 10 mg of glycoside isoflavones was dissolved in a 0.01 mol / L gallic acid solution was prepared, and then 0.3 ml of the mixed solution was added to the chloroauric acid solution and stirred for 30 minutes, thereby Gold nanoparticles were prepared.

preparation example 2

[0036] Preparation Example 2: Preparation of surface-treated gold nanoparticles (PI-Au NPs) with protocatechuic acid and isoflavones

[0037] Chlorauric acid (HAuCl 4 ) (7.8 mg, 0.02 mmol) was dissolved in 20 ml of distilled water, thereby preparing chloroauric acid. Then, prepare the mixed solution that has dissolved the isoflavones of 10mg to the protocatechuic acid solution of 0.01mol / L, afterward, this mixed solution of 0.3ml is added in the described chloroauric acid solution, and stir 30 minutes, by This produced gold nanoparticles.

Embodiment 1

[0038] Embodiment one : Cytotoxicity Assay of Gold Nanoparticles

[0039] In order to confirm the cytotoxicity of the gold nanoparticles provided by the present invention, the following test was carried out by WST-8 using L-929 cells which are a kind of muscle cells.

[0040] Specifically, the gold nanoparticles (GI-Au NPs, PI-Au NPs) of 0~50ug / ml prepared in the preparation example 1 and preparation example 2 were respectively added to the cell culture area with L-929 cells ( well), cultivated for seven days. After culturing, the absorbance at 450 nm was measured by immunoassay (ELISA), thereby confirming the cell viability. And, L-929 cells treated with 25 μg / ml and 50 μg / ml gold nanoparticles (GI-Au NPs, PI-Au NPs) were observed by scanning electron microscope and transmission electron microscope.

[0041] figure 1 Shows the survival rate of L-929 cells based on the concentration (0~50ug / ml) and days (one day, three days, five days, seven days) of the gold nanoparticle...

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Abstract

The present invention relates to a cosmetic composition for preventing skin aging containing, as active ingredients, gold nanoparticles which have been surface-treated with a mixed solution which has one organic acid, selected from gallic acid and protocatechuic acid, and which has isoflavones. The gold nanoparticles (GI-Au NPs, PI-AU NPs) which have been surface-treated with phytochemicals according to the present invention exhibit no cytotoxicity, have a superior antioxidant effect, have a superior skin-regenerating effect due to the suppression of skin cell collagen cleaving enzymes (MMP-1 and MMP-8), and have a superior superoxide dismutase (SOD) activity and thus a superior degree of antioxidation in skin cells, and therefore may be useful as a cosmetic composition for preventing skin aging.

Description

technical field [0001] The present invention relates to a cosmetic composition for preventing skin aging containing gold nanoparticles surface-treated with phytochemicals as an active ingredient, and particularly relates to a cosmetic composition containing one selected from gallic acid and protocatechin. A cosmetic composition for preventing skin aging that contains gold nanoparticles surface-treated with a mixed solution of an organic acid and isoflavone as an active ingredient. Background technique [0002] The main causes of skin aging include sunlight and active oxygen. Active oxygen is a substance that plays a role of decomposing foreign substances to remove foreign substances in the process of removing foreign substances that have entered the body. Although it plays a positive role, if excessive active oxygen is produced due to various reasons, it will not only damage its own cell tissue, but also combine with unsaturated fatty acids in the body to form lipid peroxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/19A61Q1/14A61Q19/08A61Q19/10A61K8/368
CPCA61K8/49A61K8/0241A61K8/19A61K2800/612A61Q1/14A61K8/498A61K2800/413A61Q19/10A61Q19/08A61K8/368A61K8/30
Inventor 李在范韩东旭黄大渊李在郁
Owner PUSAN NAT UNIV IND UNIV COOPERATION FOUND
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