Application of coumarin in preparing formation inhibitors of advanced glycation end products (AGEs)

Abstract

The invention discloses an application of coumarin with a structure of formula IA or formula IB in preparing formation inhibitors of AGEs. Coumarin compounds can be used for treating and preventing various chronic diseases caused by the formation and the crosslinking of the AGEs, can also be used for preparing cosmetics with epidermis and papillary dermis anti-aging and remodeling activities and/or anti-wrinkle activities for inhibiting the formation and the crosslinking of the AGEs, and can further be used for preparing chemical agents for preventing denaturation of protein in food.

Description

technical field The invention relates to the field of chemical medicine, in particular to the application of coumarin in the preparation of AGEs formation inhibitors. Background technique Advanced glycation endproducts (advanced glycation endproducts, AGEs) refer to the stable co-formation of macromolecules such as proteins, lipids or nucleic acids that spontaneously react with glucose or other reducing monosaccharides without the participation of enzymes. Valence adducts (Bierhaus et al., 1998). This reaction process is called non-enzymatic glycosylation reaction (also called Maillard reaction). The formation of AGEs is a slow process. First, the free amino group reacts with the aldehyde group in the sugar molecule to form a schiff base, and then rearranges to produce a reversible early glycosylation product-amadori product, which then undergoes complex molecular rearrangements. Finally, irreversible advanced glycation end products are formed. More and more evidence show...

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Problems solved by technology

However, this dysfunction of detoxification metabolism leads to an increa