2-pyridone compounds

A compound and pyridone technology, applied in the field of novel 2-pyridone compounds, can solve problems such as reducing GK activity
CN102884047AInactive Publication Date: 2013-01-16NISSAN CHEM IND LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NISSAN CHEM IND LTD
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

2-Pyridone compounds represented by general formula [1], tautomers or stereoisomer thereof, pharmaceutically acceptable salts of the same, or solvates thereof have excellent GK-activating activity and therefore are useful as drugs. In general formula [1], A is a benzene ring or a pyridine ring; X is a structure represented by general formula [3]; V is a single bond or lower alkylene; W is a single bond, an ether linkage, or lower alkylene (which may contain an ether linkage).
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Description

technical field

[0001] The present invention relates to novel 2-pyridone compounds having glucokinase activating effect, and to pharmaceuticals comprising the compounds as active ingredients. Background technique

[0002] Glucokinase (hereinafter referred to as GK) belongs to the hexokinase family, and catalyzes the phosphorylation of glucose taken up into cells such as pancreatic β cells or hepatocytes. GK in the liver and GK in pancreatic β cells differ from each other in the sequence of the N-terminal 15 amino acids due to differences in splicing, but are identical enzymatically. GK has a high affinity for glucose, S 0.5 is about 10 mM and is not inhibited by the product, glucose 6-phosphate. Therefore, its reaction rate responds sensitively to physiological changes in blood glucose levels. GK in pancreatic β-cells regulates glucose-dependent insulin secretion, while GK in the liver regulates the glycolytic pathway or glycogenogenesis so that blood glucose levels are m...

Claims

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