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2-pyridone compounds
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A compound and pyridone technology, applied in the field of novel 2-pyridone compounds, can solve problems such as reducing GK activity
Inactive Publication Date: 2013-01-16
NISSAN CHEM IND LTD
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Mutations in these genes have been shown to reduce GK activity
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Abstract
2-Pyridone compounds represented by general formula [1], tautomers or stereoisomer thereof, pharmaceutically acceptable salts of the same, or solvates thereof have excellent GK-activating activity and therefore are useful as drugs. In general formula [1], A is a benzene ring or a pyridine ring; X is a structure represented by general formula [3]; V is a single bond or lower alkylene; W is a single bond, an ether linkage, or lower alkylene (which may contain an ether linkage).
Description
technical field [0001] The present invention relates to novel 2-pyridone compounds having glucokinase activating effect, and to pharmaceuticals comprising the compounds as active ingredients. Background technique [0002] Glucokinase (hereinafter referred to as GK) belongs to the hexokinase family, and catalyzes the phosphorylation of glucose taken up into cells such as pancreatic β cells or hepatocytes. GK in the liver and GK in pancreatic β cells differ from each other in the sequence of the N-terminal 15 amino acids due to differences in splicing, but are identical enzymatically. GK has a high affinity for glucose, S 0.5 is about 10 mM and is not inhibited by the product, glucose 6-phosphate. Therefore, its reaction rate responds sensitively to physiological changes in blood glucose levels. GK in pancreatic β-cells regulates glucose-dependent insulinsecretion, while GK in the liver regulates the glycolytic pathway or glycogenogenesis so that blood glucose levels are m...
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