Solid dispersion of arctigenin and oral solid preparation

A technology of solid dispersion and arctigenin, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of low bioavailability and poor oral absorption of arctigenin. , to achieve the effect of simple preparation process, improved in vitro dissolution rate, and improved stability

Active Publication Date: 2013-01-23
LUNAN BETTER PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the deficiencies in the prior art, the object of the present invention is to provide a solid dispersion of arctigenin and an oral solid preparation by studying the physical and chemical properties of arctigenin, so as to improve the poor oral absorption of arctigenin, biological The problem of low utilization

Method used

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  • Solid dispersion of arctigenin and oral solid preparation
  • Solid dispersion of arctigenin and oral solid preparation
  • Solid dispersion of arctigenin and oral solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 melting method prepares arctigenin solid dispersion

[0018] Component Ratio

[0019] Arctigenin 1

[0020] Polyethylene glycol 4000 1

[0021] Preparation process: Take the prescribed amount of polyethylene glycol 4000, put it in a suitable container, heat it in a 60°C water bath until the polyethylene glycol 4000 is completely melted, add arctigenin fine powder and stir quickly until it is evenly dispersed, and spread the mixture into thin Put the layer into the refrigerator for rapid cooling, and after the mixture is completely solidified, take it out, pulverize it, and sieve it to obtain the arctigenin solid dispersion.

Embodiment 2

[0022] Embodiment 2 melting method prepares arctigenin solid dispersion

[0023]

[0024] Preparation process: Take the prescription amount of polyethylene glycol 6000 and polyoxyethylene 40 stearate, put them in a suitable container, heat them in a water bath at 80°C until they are completely melted, add arctigenin fine powder and stir quickly until they are evenly dispersed, Drop the mixture into simethicone oil at about 4°C for cooling with drop pills, take out after the drop pills are formed, and deoil to obtain arctigenin solid dispersion drop pills.

Embodiment 3

[0025] Embodiment 3 melting method prepares arctigenin solid dispersion

[0026] Component Ratio

[0027] Arctigenin 1

[0028] Poloxamer 5

[0029] Preparation process: Take the prescribed amount of poloxamer, put it in a suitable container, heat it in a water bath at 60°C until it is completely melted, add arctigenin fine powder and stir quickly until it is evenly dispersed, let stand to remove air bubbles, and spread the mixture into a thin layer Put it into the refrigerator for rapid cooling, and after the mixture is completely solidified, take it out, pulverize it, and sieve it to obtain the arctigenin solid dispersion.

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Abstract

The invention relates to a solid dispersion of arctigenin and an oral solid preparation. The solid dispersion consists of the arctigenin and a carrier material, wherein the weight ratio of the arctigenin to the carrier material is 1:1-1:50. The defects of poor oral administration absorption and low bioavailability of the arctigenin are overcome, stability of the arctigenin is improved, objectionable odor and irritation of medicaments are concealed, and a preparation technology is simple and suitable for industrialized production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a solid dispersion of arctigenin and an oral solid preparation. Background technique [0002] Arctium burdock is the dry and ripe fruit of the Compositae plant Burdock. It is a commonly used traditional Chinese medicine. It has the functions of evacuating wind-heat, clearing the lungs and rash, detoxifying and relieving the throat. It is used for wind-heat cold, cough with excessive phlegm, measles, rubella, sore throat, Pruritus mumps erysipelas, carbuncle sores. The traditional Chinese medicine contains lignans, mainly arctiin and arctigenin. Although the content of arctigenin (also known as arctigenin) in arctium is very low, but its precursor arctiin is high in the traditional Chinese medicine burdock and burdock burdock fruit, so a large amount of arctiin can be obtained through the conversion of arctiin aglycone. According to literature reports, arctiin is deco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K31/365A61K47/38A61K47/34A61K47/32A61K47/18A61K47/12A61P31/04A61P31/12A61P35/00
Inventor 赵志全陈小伟郝贵周李国庆
Owner LUNAN BETTER PHARMA
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