Nanometer medicine particle, preparation method and application thereof

A nano-medicine and particle technology, applied in the field of nano-medicine particles and its preparation, can solve the problems of slow preparation speed and achieve the effects of easy operation, simple and easy preparation method, and improved photostability

Active Publication Date: 2013-05-15
珠海中科先进技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above two methods for preparing nanoparticles in the prior art all adopt the method of stirring and mixing, which requires several hours of reaction time, and the preparation speed is relatively slow.

Method used

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  • Nanometer medicine particle, preparation method and application thereof
  • Nanometer medicine particle, preparation method and application thereof
  • Nanometer medicine particle, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Polylactic acid-glycolic acid copolymer is dissolved in acetonitrile to obtain polylactic acid-glycolic acid copolymer acetocyanide solution with a concentration of 2mg / mL;

[0039] (2) 180 μg of phospholipids, 120 μg of DSPE-PEG-MAL, 750 μg of doxorubicin, and 750 μg of indocyanine green were dissolved in 3 mL of 4% ethanol aqueous solution to obtain a mixed ethanol aqueous solution, in which the green indocyanine green appeared to be insoluble and sink;

[0040] (3) Add 1mL polylactic acid-glycolic acid copolymer acetocyanide solution dropwise to 3mL mixed ethanol aqueous solution for reaction, use an ultrasonic cell disruptor to perform ultrasonication at a frequency of 20KHz and a power of 130W, and the ultrasonication time is 5min. After ultrasonication, The precipitation in step (2) disappears, and the solution is dark green;

[0041] (4) The ultrasonicated solution is centrifuged and ultrafiltered twice with a 10KDa ultrafiltration tube to obtain nano drug pa...

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Abstract

The invention discloses a nanometer medicine particle. The nanometer medicine particle comprises a hydrophobic polymer, a single-layer lipid molecule, an amphipathy macromolecular compound, at least one chemotherapy drug attached to the hydrophobic polymer, and at least one near-infrared photothermal conversion agent, wherein the hydrophobic polymer, the at least one chemotherapy drug attached to the hydrophobic polymer, and the at least one near-infrared photothermal conversion agent form a hydrophobic core; the single-layer lipid molecule surrounds the surface of the hydrophobic core to form an intermediate layer; and the amphipathy macromolecular compound intersperses in the intermediate layer to form a shell. The invention also provides a preparation method of the nanometer medicine particle. The nanometer medicine particle can realize the combined treatment of thermotherapy and chemotherapy and has high biocompatibility; and the preparation method is simple, convenient and easy to carry out.

Description

technical field [0001] The invention relates to the field of drug carriers, in particular to a nano drug particle and a preparation method thereof. Background technique [0002] Normal tissue homeostasis is achieved by a complex balance between cell proliferation rates and cell death. Disruption of this balance by an increase in cell proliferation rate or a decrease in cell death rate leads to abnormal growth of cells and is a major event leading to cancer formation. Conventional strategies in cancer treatment include chemotherapy, radiotherapy, surgery, biological therapy, or combinations thereof. [0003] Chemotherapy, that is, the use of chemical drugs to kill tumor cells, inhibit the proliferation of tumor cells and promote the differentiation of tumor cells, is an important measure for the treatment of cancer. For example: Doxorubicin is an antitumor antibiotic, which can inhibit the synthesis of RNA and DNA, has inhibitory effects on tumor cells of various growth cyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/34A61P35/00
Inventor 蔡林涛郑明彬龚萍岳彩霞赵鹏飞郑翠芳
Owner 珠海中科先进技术研究院有限公司
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