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Medicine component used for curing or lightening melancholia or neurodegeneration disease

A neurodegenerative, compositional technology, used in neurological diseases, drug combinations, pharmaceutical formulations, etc.

Inactive Publication Date: 2013-06-05
鲍 力恒 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese herbal medicines have been used in the treatment of diseases for more than a thousand years, but most of them are empirical prescriptions and have not been tested by modern pharmacology. Therefore, it is urgent to find mild Chinese herbal medicines as antidepressant and neuroprotective agents

Method used

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  • Medicine component used for curing or lightening melancholia or neurodegeneration disease
  • Medicine component used for curing or lightening melancholia or neurodegeneration disease
  • Medicine component used for curing or lightening melancholia or neurodegeneration disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Experiment of Promoting New Generation of Neural Stem Cells

[0059] In this example, the ability of neural stem cells was observed by using mouse neural stem cell line 9601 (mouse neural stem cell, mNSC 9601) culture and intermediate filament protein immunofluorescence staining (nestia immunofluorescence staining) as described in "Materials and Methods".

[0060] Figure 2A It is a cell type diagram of neural stem cells cultured in DMEM-HG cell culture medium containing fetal bovine serum; Figure 2B It is a cell type diagram of neural stem cells cultured in DMEM-F12 culture medium containing epithelial growth factor, basic fibroblast growth factor and N2 nutrient solution without fetal bovine serum; Figure 2C It is a suspension neural stem cell sphere cultured in DMEM-HG medium containing fetal bovine serum for 3 to 5 days of cell type diagram; Figure 2D-Figure 2E The suspended neural stem cell spheres were stained with Hoechst stain or intermediate fila...

Embodiment 2

[0062] Example 2 Experiment of promoting the regeneration of neural stem cells with a single Chinese herbal medicine in vitro

[0063] In this example, the MTS assay as described in "Materials and Methods" was used to observe the effect of a single Chinese herbal medicine on the survival rate of neural stem cells in vitro. As shown in Table 2, the smaller the numerical order, the more the Chinese herbal medicine can promote the regeneration of neural stem cells. The first 8 Chinese herbal medicines that can promote the growth of neural stem cells are Scutellaria baicalensis, Cortex Phellodendri, Rhizoma Chuanxiong, Corydalis Corydalis, Ginseng, Fangfeng, Astragalus and Eucommia.

[0064] Table 2 Ranking list of 56 kinds of unilateral Chinese herbal medicines promoting the regeneration of neural stem cells

[0065] 1 skullcap

[0066] like Figure 3 to Figure 4 Shown is the comparison of the effects of the above 7 kinds of single Chinese herbal medicines (except gin...

Embodiment 3

[0067] Example 3 Measuring changes in mouse body weight and plasma corticosterone concentration

[0068] In this example, the depression-like animal model experiment as described in "Materials and Methods" is used together with biochemical analysis to evaluate the effect of the aforementioned seven single Chinese herbal medicines (scutellaria baicalensis, Phellodendri baicalensis, Rhizoma Chuanxiong, Corydalis Corydalis, Fangfeng, Huangqi and Eucommia) on restoring CMS. Effects of body weight and plasma corticosterone concentrations in mice. like Figure 5A Shown, with duloxetine (duloxetine) and Prozac as the positive control group, the mice can significantly reduce the CMS led to increased corticosterone concentrations in mouse plasma (p Figure 5B As shown, mice can significantly recover CMS and cause mice to lose weight (p Image 6 As shown, oral administration of Fangfeng or Eucommia to mice for 14 days can significantly reduce CMS and lead to weight loss of mice (Fangfeng...

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Abstract

The invention relates to a medicine component used for curing or lightening melancholia or a neurodegeneration disease. The medicine component used for curing or lightening the melancholia or the neurodegeneration disease comprises at least one type of Chinese herbal medicine which is chosen from a group which is composed of ortex phellodendri, radix scutellariae, rhizoma chuanxiong,astragalus, eucommia, Saposhnikovia divaricata and rhizoma corydalis, and the Chinese herbal medicine in the group is capable of promoting rebirth of a neural stem cell and adjusting hypothalamus-infracerebral gland-adrenal gland axis or antiapoptosis. The invention further provides a purpose used for manufacturing the medicine component used for curing or lightening the melancholia or the neurodegeneration disease. The purpose used for manufacturing the medicine component used for curing or lightening melancholia or the neurodegeneration disease comprises at least one type of the Chinese herbal medicine which is capable of promoting rebirth of the neural stem cell and adjusting the hypothalamus-infracerebral gland-adrenal gland axis or the antiapoptosis.

Description

technical field [0001] The invention relates to a medicinal composition for treating or alleviating depression or neurodegenerative diseases and its application. Background technique [0002] With the aging of the population and the increase of various pressures that people bear, the incidence of depression and neurodegenerative diseases is getting higher and higher. How to improve and treat depression and neurodegenerative diseases has become an important topic of current research. [0003] Long-term stress may be the main cause of depression. Studies have shown that exposing rats to chronic mild stress (chronic mild stress, CMS) environments can trigger changes in behavioral patterns, neurochemistry, neuroendocrine, and neuroimmunity. A series of changes. CMS can trigger the core symptom of depression, anhedonia, which is manifested in a reduced response to rewards, such as reduced intake of favorite sugar water. CMS can also trigger behaviors such as increased anxiety a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P25/00A61P25/14A61P25/16A61P25/18A61P25/24A61P25/28
Inventor 鲍力恒孙高歌吕绍玮
Owner 鲍 力恒
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