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Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition

A technology of respiratory diseases and compositions, applied in the field of medicine

Active Publication Date: 2013-07-10
天津中医药大学第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no clinically available Chinese patent medicine specifically for the treatment of pulmonary fibrosis, so it is of great significance to develop drugs that can be used to treat and / or delay the progression of this disease

Method used

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  • Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition
  • Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition
  • Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1. Preparation of pharmaceutical composition

[0073] Accurately weigh 3000g of Astragalus, 2000g of Angelica, 2000g of Zedoary Turmeric, 2000g of Cornus, 2000g of Aster, 1600g of Scutellaria, 1000g of Zhebei, 1000g of Licorice, Eight Herbs, add water and decoct twice, 2 hours each time, 10 times the amount of water for the first time , The second time is 8 times the amount of water, filtered, the combined filtrate is concentrated to a clear paste with a relative density of 1.30 to 1.32 (55°C), dried (drying temperature is 60°C), crushed into fine powder, and sieved to obtain the composition of the present invention , Called "Qishu Granules" (represented by the code name "QZKL", the same below), 5120g, batch number: QZKL-1.

Embodiment 2

[0074] Example 2. Preparation of pharmaceutical composition

[0075] Accurately weigh 280g astragalus, angelica 180g, zedoary turmeric 180g, cornus 180g, aster 220g, scutellaria 140g, zhebei 80g, licorice 80g, eight medicinal materials, decocted twice with water, 2 hours each time, 10 times the amount of water for the first time , The second time is 8 times the amount of water, filtered, the combined filtrate is concentrated to a clear ointment with a relative density of 1.30 to 1.32 (55°C), dried (drying temperature is 60°C), crushed into fine powder, and sieved to obtain the drug combination of the present invention Deqishu Granules 518g, batch number: QZKL-2.

Embodiment 3

[0076] Example 3. Preparation of pharmaceutical composition

[0077] Accurately weigh 320g of astragalus, 220g of angelica, 180g of zedoary turmeric, 220g of cornus, 180g of aster, 140g of scutellaria, 100g of zhebei, 80g of licorice, eight medicinal materials, decocting twice, 2 hours each time, 10 times the amount of water for the first time , The second time is 8 times the amount of water, filtered, the combined filtrate is concentrated to a clear cream with a relative density of 1.30 to 1.32 (55°C), dried (drying temperature is 60°C), crushed into fine powder, sieved to obtain Qishu granules 540g, batch number: QZKL-3.

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Abstract

The invention relates to a traditional Chinese medicine composition, a pharmaceutical composition as well as a preparation method thereof and a use of the traditional Chinese medicine composition and the pharmaceutical composition. The preparation materials of active ingredients of the pharmaceutical composition include the following materials in parts by weight: 28-32 parts of astragalus mongholicus and at least one of codonopsis pilosula, ginseng, radix pseudostellariae and American ginseng, 18-22 parts of Chinese angelica and at least one of prepared rehmannia root and dried rehamnnia root, 18-22 parts of dogwood and at least one of polygonum multiflorum, schisandra chinensis, placenta hominis and gecko, 14-18 parts of curcuma zedoary and at least one of rhizoma sparganii, root of red-rooted salvia and red flower, 14-18 parts of scutellaria baicalensis and at least one of polygonum cuspidatum and rhizoma anemarrhenae, 18-22 parts of radix asteris and at least one of radix stemonae and flos farfarae, 8-12 parts of fritillaria thunbergii and 8-12 parts of liquorices.

Description

Technical field [0001] The present invention relates to the field of medical technology, in particular to a pharmaceutical composition for treating respiratory diseases, especially pulmonary fibrosis, and uses thereof. Background technique [0002] Respiratory diseases are a major disease that endangers the health of humans and animals. Among them, diffuse interstitial lung disease (ILD) is a large group of diseases with diffuse alveolar unit chronic inflammation and interstitial fibrosis as the main pathological features. It is also called diffuse solid lung disease (diffuse lung disease). parenchymal lung disease, DPLD). This type of disease manifests as progressive exertional shortness of breath, restrictive ventilatory dysfunction with diffuse dysfunction, hypoxemia, and diffuse lung lesions on imaging. As the disease progresses, the alveolar-capillary functional unit is gradually lost, and eventually develops into diffuse pulmonary fibrosis and honeycomb, leading to respir...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K36/902A61K36/904A61K36/8966A61P11/00A61K35/50A61K35/56A61K35/583
Inventor 孙增涛
Owner 天津中医药大学第二附属医院
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