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Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition

A technology for respiratory diseases, composition, applied in the field of medicine

Active Publication Date: 2014-12-03
天津中医药大学第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no clinically available Chinese patent medicine specifically for the treatment of pulmonary fibrosis, so it is of great significance to develop drugs that can be used to treat and / or delay the progression of this disease

Method used

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  • Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition
  • Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition
  • Pharmaceutical composition for preventing/treating respiratory system disease and use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1, the preparation of pharmaceutical composition

[0073] Accurately weigh 3000g of astragalus, 2000g of angelica, 1600g of zedoary, 2000g of dogwood, 2000g of aster, 1600g of scutellaria baicalensis, 1000g of zhebei, 1000g of licorice, eight herbs, add water and decoct twice, 2 hours each time, 10 times the amount of water for the first time , the second time 8 times the amount of water, filter, combine the filtrate and concentrate to a clear paste with a relative density of 1.30-1.32 (55°C), dry (drying temperature is 60°C), pulverize into fine powder, and sieve to obtain the composition of the present invention , called "Qizhu Granules" (indicated by the code "QZKL", the same below), 5120g, batch number: QZKL-1.

Embodiment 2

[0074] Embodiment 2, the preparation of pharmaceutical composition

[0075] Accurately weigh 280g of astragalus, 180g of angelica, 180g of zedoary, 180g of dogwood, 220g of aster, 140g of scutellaria baicalensis, 80g of zhebei, 80g of licorice, and eight herbs. , the second time 8 times the amount of water, filter, combine the filtrate and concentrate to a clear paste with a relative density of 1.30-1.32 (55°C), dry (drying temperature is 60°C), pulverize into fine powder, and sieve to obtain the pharmaceutical combination of the present invention Deqizhu Granules 518g, batch number: QZKL-2.

Embodiment 3

[0076] Embodiment 3, the preparation of pharmaceutical composition

[0077] Accurately weigh 320g of astragalus, 220g of angelica, 180g of zedoary, 220g of dogwood, 180g of aster, 140g of scutellaria baicalensis, 100g of zhebei, 80g of licorice, and eight herbs. , the second time 8 times the amount of water, filter, combine the filtrate and concentrate to a clear paste with a relative density of 1.30-1.32 (55°C), dry (drying temperature is 60°C), pulverize into fine powder, and sieve to obtain Qizhu granules 540g, batch number: QZKL-3.

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Abstract

The invention relates to a traditional Chinese medicine composition, a pharmaceutical composition as well as a preparation method thereof and a use of the traditional Chinese medicine composition and the pharmaceutical composition. The preparation materials of active ingredients of the pharmaceutical composition include the following materials in parts by weight: 28-32 parts of astragalus mongholicus and at least one of codonopsis pilosula, ginseng, radix pseudostellariae and American ginseng, 18-22 parts of Chinese angelica and at least one of prepared rehmannia root and dried rehamnnia root, 18-22 parts of dogwood and at least one of polygonum multiflorum, schisandra chinensis, placenta hominis and gecko, 14-18 parts of curcuma zedoary and at least one of rhizoma sparganii, root of red-rooted salvia and red flower, 14-18 parts of scutellaria baicalensis and at least one of polygonum cuspidatum and rhizoma anemarrhenae, 18-22 parts of radix asteris and at least one of radix stemonae and flos farfarae, 8-12 parts of fritillaria thunbergii and 8-12 parts of liquorices.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating respiratory diseases, especially pulmonary fibrosis and its application. Background technique [0002] Respiratory diseases are a major disease that endangers human and animal health. Among them, diffuse interstitial lung disease (interstitial lung disease, ILD) is a large group of diseases characterized by chronic inflammation of diffuse alveolar units and interstitial fibrosis, also known as diffuse parenchymal lung disease (diffuse parenchymal lung disease). parenchymal lung disease, DPLD). This type of disease manifests as progressive exertional shortness of breath, restrictive ventilatory dysfunction with diffusion dysfunction, hypoxemia, and diffuse lesions in both lungs on imaging. As the disease progresses, alveolar-capillary functional units are gradually lost, and eventually diffuse pulmonary fibrosis and honeycombing develop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/902A61K36/904A61K36/8966A61P11/00A61K35/50A61K35/56A61K35/583
Inventor 孙增涛
Owner 天津中医药大学第二附属医院
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