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Traditional Chinese medicine composition used for treating chronic liver diseases

A technology for chronic liver disease and composition, applied in the field of traditional Chinese medicine compositions for the treatment of chronic liver disease, can solve problems such as no literature report found

Inactive Publication Date: 2013-08-21
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it has been verified that there is no patent publication related to the content of this application, and no literature reports on the application of the same traditional Chinese medicine prescription in the field of liver disease as this patent application have been found. Therefore, the content claimed in this patent application is the first discovery, with novelty and creativity

Method used

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  • Traditional Chinese medicine composition used for treating chronic liver diseases
  • Traditional Chinese medicine composition used for treating chronic liver diseases
  • Traditional Chinese medicine composition used for treating chronic liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Use CCl 4 The induced liver fibrosis model in mice confirmed that Chinese herbal compound can significantly inhibit the progression of liver fibrosis and the formation of liver cirrhosis.

[0018] 1. Materials and methods:

[0019] 1.1 Animals

[0020] 40 clean-grade male C57BL / 6 mice, 8 weeks old, weighing 20±3g, purchased from Shanghai Experimental Animal Center of Chinese Academy of Sciences. The animal center of Shanghai University of Traditional Chinese Medicine raises, builds and observes, and eat freely.

[0021] 1.2 Main reagents and equipment

[0022] Carbon Tetrachloride (CCl 4 ) Was purchased from Sinopharm Group, hydroxyproline (Hyp) standard was purchased from Tokyo Chemical Industry Co., Ltd.; Olympus IX70 optical microscope was purchased from Olympus.

[0023] 1.3 Medicine (using the Chinese medicine composition of the present invention)

[0024] Triangle 6-18g, Curcuma 6-18g, Turtle carapace 9-30g, the above drugs are extracted with water to make an extract, prepar...

Embodiment 2

[0050] Example 2 Preparation of tablets

[0051] Weigh the following raw materials: 6g of tricorne, 6g of turmeric, and 9g of turtle shell to make a coarse powder, soak in 15 times the amount of water for 0.5 hours each time, heat and reflux for extraction 2 times, concentrate the filtrate to the extract, dry it after vacuum drying Ointment; after adding appropriate amount of excipients, tablets are made. Each tablet contains 90 mg of traditional Chinese medicine composition. Usage: 5 tablets each time, 3 times a day, 7 days a week, 12 weeks as a course of treatment.

Embodiment 3

[0052] Example 3 Preparation of granules

[0053] Weigh the following raw materials: 18g of tricorne, 18g of turmeric, 30g of turtle shell, make a coarse powder, soak in 15 times the amount of water for 0.5 hours each time, heat and reflux for extraction 2 times, concentrate the filtrate to the extract, dry it after vacuum drying Paste: After adding appropriate amount of auxiliary materials, granules are prepared. Each bag of granules contains 175mg of Chinese medicine composition. Usage: 3 bags each time, 3 times a day, 7 days a week, 12 weeks as a course of treatment.

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Abstract

The invention discloses a traditional Chinese medicine composition used for treating chronic liver diseases. The composition is composed of the raw medicine materials of, by weight, 6-18 parts of common burreed tuber, 6-18 parts of blue turmeric rhizome, and 9-30 parts of turtle shell. According to the invention, blood-circulation-activating, stasis-removing, hard-mass-softening, and stagnation-eliminating traditional Chinese medicines are used for producing the medicine composition with functions of hepatic fibrosis inhibiting and hepatic damage inhibiting. Classic animal model experiments and validation are carried out. As a result, the traditional Chinese medicine composition provided by the invention assists in substantially reducing model rat liver tissue collagen content, reducing hepatic fibrosis degree and hepatic damage degree, effectively inhibiting hepatic fibrosis development, and promoting hepatic fibrosis reversing. The composition provided by the invention can be used for treating and preventing various diseases such as chronic hepatitis, liver fibrosis, cirrhosis, liver tumor, and the like. The medicine can be prepared into oral solid preparations such as tablets, granules, capsules, and the like.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic liver disease and its use. Background technique [0002] Liver cirrhosis is the main outcome of the development of chronic hepatitis B and other liver diseases. At present, there are about 30 million patients with chronic hepatitis B in my country. After the pathological process of liver fibrosis, 20% to 40% of chronic hepatitis B patients eventually develop cirrhosis. However, post-hepatitis B liver cirrhosis is one of the main death diseases in my country, and effective treatment of hepatitis B cirrhosis is an important way to reduce the mortality of hepatitis B. International multi-center clinical studies have shown that effective antiviral therapy can partially reverse liver fibrosis, but the overall effective rate of treatment for 48 weeks (weeks) i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/16A61P35/00
Inventor 刘平宁冰冰慕永平孙明瑜陈高峰张笑刘成海胡义扬徐列明朱邦贤王峥涛
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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