Traditional Chinese medicine composition used for treating chronic liver diseases

A technology for chronic liver disease and composition, applied in the field of traditional Chinese medicine compositions for the treatment of chronic liver disease, can solve problems such as no literature report found

Inactive Publication Date: 2014-12-31
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it has been verified that there is no patent publication related to the content of this application, and no literature reports on the application of the same traditional Chinese medicine prescription in the field of liver disease as this patent application have been found. Therefore, the content claimed in this patent application is the first discovery, with novelty and creativity

Method used

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  • Traditional Chinese medicine composition used for treating chronic liver diseases
  • Traditional Chinese medicine composition used for treating chronic liver diseases
  • Traditional Chinese medicine composition used for treating chronic liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Using CCl 4 The induced mouse liver fibrosis model confirmed that the traditional Chinese medicine compound can significantly inhibit the progression of liver fibrosis and the formation of liver cirrhosis.

[0018] 1. Materials and methods:

[0019] 1.1 Animals

[0020] Forty clean-grade male C57BL / 6 mice, 8 weeks old, weighing 20±3g, were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. Raised, modeled and observed in the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, free to eat and drink.

[0021] 1.2 Main reagents and equipment

[0022] Carbon tetrachloride (CCl 4 ) was purchased from Sinopharm Group, the standard product of hydroxyproline (Hyp) was purchased from Tokyo Chemical Industry Co., Ltd.; the Olympus IX70 optical microscope was purchased from Olympus Company.

[0023] 1.3 medicine (using Chinese medicine composition of the present invention)

[0024] Sanleng 6-18g, Curcuma ...

Embodiment 2

[0050] The preparation of embodiment 2 tablet

[0051] Weigh the following raw materials: 6g trigonum, 6g curcuma, and 9g turtle shell, make coarse powder, soak in 15 times the amount of water each time for 0.5 hour, heat and reflux for extraction twice, concentrate the filtrate to an extract, and dry infusion after vacuum drying paste; after adding appropriate amount of excipients, tablets are prepared. Each tablet contains 90 mg of the traditional Chinese medicine composition. Usage: 5 tablets each time, 3 times a day, 7 days a week, 12 weeks as a course of treatment.

Embodiment 3

[0052] The preparation of embodiment 3 granules

[0053] Weigh the following raw materials: 18g trigonum, 18g curcuma, and 30g turtle shell, and make coarse powder, soak in 15 times the amount of water for 0.5 hour each time, heat and reflux for extraction twice, concentrate the filtrate to extract, and dry infusion after vacuum drying paste; after adding appropriate amount of excipients, granules are obtained. Each bag of granules contains 175 mg of the traditional Chinese medicine composition. Usage: 3 bags each time, 3 times a day, 7 days a week, 12 weeks as a course of treatment.

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Abstract

The invention discloses a traditional Chinese medicine composition used for treating chronic liver diseases. The composition is composed of the raw medicine materials of, by weight, 6-18 parts of common burreed tuber, 6-18 parts of blue turmeric rhizome, and 9-30 parts of turtle shell. According to the invention, blood-circulation-activating, stasis-removing, hard-mass-softening, and stagnation-eliminating traditional Chinese medicines are used for producing the medicine composition with functions of hepatic fibrosis inhibiting and hepatic damage inhibiting. Classic animal model experiments and validation are carried out. As a result, the traditional Chinese medicine composition provided by the invention assists in substantially reducing model rat liver tissue collagen content, reducing hepatic fibrosis degree and hepatic damage degree, effectively inhibiting hepatic fibrosis development, and promoting hepatic fibrosis reversing. The composition provided by the invention can be used for treating and preventing various diseases such as chronic hepatitis, liver fibrosis, cirrhosis, liver tumor, and the like. The medicine can be prepared into oral solid preparations such as tablets, granules, capsules, and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic liver disease and its application. Background technique [0002] Liver cirrhosis is the main outcome of chronic hepatitis B and other liver diseases. At present, there are about 30 million chronic hepatitis B patients in my country. After the pathological process of liver fibrosis, 20% to 40% of chronic hepatitis B patients will eventually develop cirrhosis. However, post-hepatitis B cirrhosis is one of the leading causes of death in my country, and effective treatment of HBV cirrhosis is an important way to reduce the mortality rate of HBV. International multi-center clinical studies have shown that effective antiviral therapy can partially reverse liver fibrosis, but the overall effective rate of 48w (week) treatment is only about 45%. Due to the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/16A61P35/00
Inventor 刘平宁冰冰慕永平孙明瑜陈高峰张笑刘成海胡义扬徐列明朱邦贤王峥涛
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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