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Medicinal composition for treating chronic hepatopathy, and its application

A technology for chronic hepatitis and drugs, which is applied in the field of pharmaceutical compositions for the treatment of chronic liver diseases, and can solve problems such as side effects, poor stability, and difficult quality control

Inactive Publication Date: 2013-06-05
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no matter the traditional Chinese medicine compound or a single active ingredient has its shortcomings
Due to the complex composition of traditional Chinese medicine, quality control is difficult, and the stability is poor, which is also one of the problems in the internationalization of Chinese medicine; and a single component or component is often difficult to achieve good effects or effective doses will cause more obvious side effects

Method used

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  • Medicinal composition for treating chronic hepatopathy, and its application
  • Medicinal composition for treating chronic hepatopathy, and its application
  • Medicinal composition for treating chronic hepatopathy, and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The optimal ratio of the composition for reducing liver collagen content was obtained by using DMN-induced rat liver fibrosis model and orthogonal design analysis.

[0020] 1. Materials and methods:

[0021] 1. Animals

[0022] 160 Wistar male rats (40 in the normal group and 120 in the model group), clean grade, weighing (150±10) g, were provided by the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. Animals were reared, modeled and observed in a clean animal room in the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, with free access to drinking water.

[0023] 2. Main reagents and equipment

[0024] Dimethylnitrosamine (Dimethylnitrosamine, DMN) and hydroxyproline (hydroxyproline, Hyp) standard products, products of Tokyo Chemical Industry Co., Ltd.; liver function kits used were purchased from Nanjing Jiancheng Biological Reagent Company; Image-Pro Plus6 .1 Professional image analysis software was purchas...

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PUM

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Abstract

The invention discloses a medicinal composition for treating chronic hepatopathy. The medicinal composition is composed of astragaloside and glycyrrhizic acid, and the weight ratio of astragaloside to glycyrrhizic acid is 3-6:1. Results of tests and verification through adopting a classic animal model show that the medicinal composition can substantially reduce the collagen content of the hepatic tissue of a model rat, mitigate the hepatic fibrosis degree and the hepatic damage degree, improve the hepatic fibrosis resistance, effectively prevent the development of the hepatic fibrosis and promote the reversion of the hepatic fibrosis, the above effects are better than effects realized through singly using the above components, and the medicinal composition can be used for treating and preventing various diseases comprising chronic hepatitis, hepatic fibrosis, hepatic cirrhosis and the like. The medicinal composition can be processed to prepare oral solid preparations comprising a tablet, a granule, a capsule and the like.

Description

[0001] This application is a divisional application of Chinese patent CN201010263205.0 (original application). The filing date of the original application is August 26, 2010. The invention is called a pharmaceutical composition for treating chronic liver disease and its application. technical field [0002] The invention relates to a pharmaceutical composition for treating chronic liver disease and its application; in particular, it relates to a pharmaceutical composition with anti-hepatic fibrosis and anti-liver damage effects and its application. Background technique [0003] Liver cirrhosis is the end stage of many chronic liver diseases, characterized by diffuse liver fibrosis with abnormal nodule formation. Liver cirrhosis is a common disease and one of the main causes of death in China. my country is an area with a high incidence of hepatitis B. There are only 30 million patients with chronic hepatitis B, of which about 30% develop into liver cirrhosis. There has been ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P1/16A61K31/704
Inventor 刘平仝欣孙明瑜陆雁陈高峰刘佳李风华刘成海胡义扬徐列明
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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