Applications of pegylated artesunate in preparing medicines capable of resisting hepatic pathological changes
A technology of polyethylene glycol artesunate and artesunate, which is applied in the direction of antineoplastic drugs, drug combinations, and pharmaceutical formulations, and can solve the problem of anti-hepatic fibrosis of polyethylene glycol artesunate that has not yet been seen
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[0027] Example 1 Study on the Effect of Polyethylene Glycol Artesunate on Rat Hepatic Fibrosis
[0028] 1. Test material
[0029] Polyethylene glycol artesunate, made by Kunming Pharmaceutical Research Institute according to the method disclosed in Example 1 of Chinese patent CN103450468B, has a structure of formula 1; artesunate, Chongqing Huafang Wulingshan Pharmaceutical Co., Ltd.; colchicine tablets , Kunming Pharmaceutical Group Co., Ltd.; hyaluronidase (HA), laminin (LN), type III procollagen (PC-III) kits, Zhongsheng Beikong Biotechnology Co., Ltd.; serum alanine transamination Enzyme (ALT), aspartate aminotransferase (AST), serum albumin (ALB), malondialdehyde (MDA), superoxide dismutase (SOD), hydroxyproline (HyP) kit, HE Dye solution, Nanjing Jiancheng Biological Engineering Co., Ltd.; carbon tetrachloride (AR), Chongqing Chuanjiang Chemical Reagent Factory; precision electronic balance, Beijing Sartorius Balance Co., Ltd.; TDL-5 centrifuge, Shanghai Anting Scientif...
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