Treatment system for in-vivo perfusion screening enrichment of stem cells

A treatment system and stem cell technology, applied in the direction of suction devices, etc., can solve the problems of complicated treatment process, difficult injection, easy spillover, etc., and achieve the effect of simplifying the treatment procedure, preventing nonunion and improving safety

Active Publication Date: 2013-08-21
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment process is relatively complicated and the cost is high, and the injected stem cell suspension is often controlled in a relatively small volume, otherwise it will be difficult to inject or easy to overflow

Method used

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  • Treatment system for in-vivo perfusion screening enrichment of stem cells
  • Treatment system for in-vivo perfusion screening enrichment of stem cells
  • Treatment system for in-vivo perfusion screening enrichment of stem cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] see figure 1 , the figure shows the structure of the first embodiment of the present invention. The treatment system 1 includes two hollow screws 111, 112, wherein the hollow screws 111, 112 all include a screw head, a screw body and a screw tail, and a cavity passing through the screw body and the screw tail is provided inside and the cavity is located at the bottom of the screw tail. The opening has a tail cap interface at the back, which can be connected to the catheter. There is a side hole on the side of the hollow screw, which can make the bone marrow blood flow into the medullary cavity smoothly. The treatment system 1 also includes two tees 121, 122, a liquid storage bag 13 and two bidirectional valve devices 141, 142 that can change the flow direction, wherein the liquid storage bag 13 has a liquid outlet 131, a liquid inlet 132 and a Liquid injection hole 133, the cavity opening at the tail of the hollow screw 111 is connected to the first port of the tee 121...

Embodiment 2

[0027] see figure 2 , the figure shows the structure of the second embodiment of the present invention. On the basis of Embodiment 1, this treatment system 1 also includes a peristaltic pump 14 on the catheter tube that is located between the two tees 121, 122, such as figure 2 As shown, it can be arranged on the catheter between the two-way valve device 142 and the tee 122 adjacent thereto.

[0028] The treatment system can provide the power to drive the bone marrow blood in the tube through the peristaltic pump.

Embodiment 3

[0030] see image 3 , the figure shows the structure of the third embodiment of the present invention. On the basis of embodiment 1 or embodiment 2, the treatment system 1 also includes a pressure gauge on the catheter between the two tees 121, 122, such as image 3 As shown, it can be installed on the catheter between the two-way valve device 141 and the adjacent tee 121 for real-time observation of the pressure inside the tube.

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Abstract

The invention discloses a treatment system for in-vivo perfusion screening enrichment of stem cells. The treatment system comprises two hollow screws, two tees, a reservoir with a liquid inlet and a liquid outlet and two two-way valve devices capable of changing flow directions, a cavity opening at the tail of one hollow screw is connected with the liquid inlet of the reservoir respectively through the tees and the two-way valve devices capable of changing the flow directions, and a cavity opening at the tail of the other hollow screw is connected with the liquid outlet of the reservoir respectively through the tees and the two-way valve devices capable of changing the flow directions. By the aid of the treatment system, in-vivo perfusion of bone marrow stem cells can be realized, circulation is formed, so that the bone marrow stem cells can be rapidly screened and enriched to a focal zone, bone regeneration and bone healing are promoted, and the treatment system can also be used for femoral neck fracture and prevention of complications such as nonunion of the femoral neck fracture bones or femoral head necrosis.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a treatment system for in vivo perfusion screening and enrichment of stem cells. Background technique [0002] It was found and confirmed in the completed National Natural Science Foundation of China (Project No. 30801175) titled "Research on Mechanism of Rapid Adhesion of Bone Marrow Mesenchymal Stem Cells and Its Application in Bone Repair" that bone marrow mesenchymal stem cells have Fast sticking effect. If the bone marrow stem cells are perfused into the fracture area and quickly adhered and enriched in the lesion area (area requiring bone repair), it can promote bone regeneration and bone healing. [0003] Therefore, how to perfuse, screen and enrich bone marrow stem cells in vivo to promote bone regeneration and bone healing has been one of the technical problems that those skilled in the art have been devoted to solving. [0004] The invention patent application with the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/00
Inventor 干耀恺戴尅戎
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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