Use of DHA, epa or DHA-derived EPA for treating a pathology associated with cellular oxidative damage

A technology of uses and cells, applied in metabolic diseases, sensory diseases, skeletal diseases, etc., can solve problems such as increasing skeletal muscle

Active Publication Date: 2013-08-28
BRUDY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surprisingly, however, AMPK activation is not the only way exercise increases skeletal muscle response to glucose (independent of insulin)

Method used

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  • Use of DHA, epa or DHA-derived EPA for treating a pathology associated with cellular oxidative damage
  • Use of DHA, epa or DHA-derived EPA for treating a pathology associated with cellular oxidative damage
  • Use of DHA, epa or DHA-derived EPA for treating a pathology associated with cellular oxidative damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0148] Materials and methods used to assess antioxidant activity

[0149] cell culture

[0150] The cell models used were foreskin cells (undifferentiated epidermal fibroblasts, CRL-2076) and ARPE-19 cells (retinal pigment epithelial cells, CRL-2302) obtained from the American Type Culture Collection . Place the cell culture in an incubator specially designed for this purpose with suitable growth conditions of 37 °C, CO 2 Concentration 5% and humidity 95%. ARPE-19 cells were grown to 0.3x10 in culture flasks containing DMEM-F12 medium (Biological Industries) 4 cells / cm 2 The confluence of the DMEM-F12 medium was supplemented with 10% fetal bovine serum, penicillin antibiotics (100 U / mL), streptomycin (100 μg / mL) and glutamine (Biological Industries). CRL-2076 fibroblasts were maintained in culture flasks containing Iscove's Modified Dulbecco's Medium (IMDM) (Biological Industrie) supplemented with 10% fetal Bovine serum, penicillin antibiotics (100 U / mL), streptomycin ...

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Abstract

The invention relates to medicine rich in docosahexaenoic acid (DHA)or eicosapentaenoic acid (EPA) or DHA-derived EPA for treating a pathology associated with cellular oxidative damage, more specifically, the medicine is used for the treatment of ,eurodegenerative diseases,oculopathy,ischemic disease, inflammatory disease,atherosclerosis, disease associated with DNA oxidative damage and disease associated with physical exercise.

Description

[0001] This application is a divisional application, the filing date of the original application is December 20, 2006, the application number is 200680048821.6 (the international application number is PCT / EP2006 / 070016), and the name is "DHA, EPA or DHA-derived EPA for Use for treating diseases related to cell oxidative damage". technical field [0002] The present invention relates to the use of an acid rich in docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) or DHA-derived EPA for the preparation of a medicament for the treatment of Diseases associated with oxidative damage. Background technique [0003] Omega-3 fatty acids are required to maintain the functional integrity of cells and are generally required for human health. Docosahexaenoic acid (22:6n-3, DHA) -- an important omega-3 component in fish oil and seaweed -- is found primarily in the brain, as well as in photoreceptors and synapses in the retina. A diet rich in DHA is initially metabolized by the li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/202A61P39/06A61P39/00A61P3/02A61P3/08A23L1/30A23C9/152A23C19/00A23L23/00
CPCA61K31/202A61K47/12A23L33/12A23V2002/00A61P13/12A61P19/02A61P21/00A61P21/02A61P21/04A61P25/00A61P25/16A61P25/28A61P27/02A61P27/12A61P29/00A61P3/02A61P3/08A61P37/02A61P39/00A61P39/06A61P43/00A61P9/00A61P9/02A61P9/04A61P9/10A61P9/14A61P3/10A23V2200/30A23V2250/1868A61K31/20A61K31/23A23C9/1528A61K8/375A61K8/361A61Q19/08
Inventor J·C·多明果佩罗J·A·威勒盖斯加西亚
Owner BRUDY TECH
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