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Method for detecting wind-cold cold granules

A detection method and a technology for colds and colds, which are applied in the field of pharmaceuticals, can solve problems such as the detection method for rare Platycodon grandiflorum, and achieve the effects of scientific and reasonable detection methods and safe and effective medication.

Active Publication Date: 2013-08-28
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still few methods for the detection of bellflower in Fenghan Ganmao Granules

Method used

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  • Method for detecting wind-cold cold granules
  • Method for detecting wind-cold cold granules
  • Method for detecting wind-cold cold granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] According to the prescription: 100g ephedra, 150g kudzu root, 150g perilla leaf, 150g fangfeng, 100g cassia twig, 100g angelica, 100g tangerine peel, 150g bitter almond, 100g bellflower, 100g licorice, 100g dried ginger. According to the following preparation method, extract the volatile oils of the above eleven herbs, perilla leaves, windproof, and angelica dahurica, add water to decoct the medicinal residues and the rest of platycodon grandiflorum, etc., for 3 hours for the first time, 2 hours for the second time, and 2 hours for the third time For 1 hour, combine the decoctions, filter, concentrate the filtrate to a clear paste with a relative density of 1.40, spray dry, add 444.5 g of white sugar and 150 g of dextrin, mix well, granulate with 70% ethanol, dry, spray volatile oil, and mix well , that is. The prepared Fenghanmao granules are brown granules in properties; the gas is fragrant, the taste is fragrant, and slightly bitter.

[0036] According to the inspec...

Embodiment 2

[0057] Take a certain batch (A) to prepare Fenghanmao granules, and identify its appearance, smell and other attributes. According to the inspection of Appendix I C of the 2010 edition of the "Chinese Pharmacopoeia", it should meet the relevant regulations under the granule. Differentiate ephedrine hydrochloride and Platycodon grandiflorum with silica gel G thin-layer plate. Implementation process is the same as embodiment 1. Determine the content of ephedrine hydrochloride according to high performance liquid chromatography.

[0058] Chromatographic conditions and system suitability test C18 column, with acetonitrile: 0.1wt% phosphoric acid aqueous solution (acetonitrile: phosphoric acid solution volume ratio: 9:87) as mobile phase; detection wavelength is 207nm. The number of theoretical plates should not be less than 3000 based on the ephedrine hydrochloride peak.

[0059] The preparation of reference substance solution gets ephedrine hydrochloride reference substance 10...

Embodiment 3

[0064] Take a certain batch (B) to prepare Fenghanmao granules, and test according to the implementation process in Example 1, and all items meet the national standards. Wherein the test of ephedrine, prepare ephedrine test solution according to embodiment 1, store respectively 0 hour (test immediately), 2 hours, 4 hours, 6 hours, 8 hours, after 10 hours according to the high efficiency in embodiment 1 The liquid chromatography test method was used for determination, and the results were 0.508mg / mL, 0.510mg / mL, 0.507mg / mL, 0.509mg / mL, 0.511mg / mL, and 0.507mg / mL. The relative standard deviation (RSD) among the results was 0.22%.

[0065] The measurement results of the reference substance solution and the test solution are stable within 10 hours after preparation, have extremely high test stability, and are not easily affected by time stagnation in the inspection process.

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Abstract

The invention discloses a method for detecting wind-cold cold granules. The method comprises thin layer identification of Chinese ephedra and platycodon root and content determination of ephedrine hydrochloride, wherein identification of the Chinese ephedra is performed by taking ephedrine hydrochloride as a reference substance and a mixed solution including ethyl acetate, methanol and water as a developing agent and using a thin layer chromatography; and the identification of the platycodon root is performed by taking a platycodon root contrast medicinal material as a reference substance and a mixed solution including n-hexane, ethyl acetate and glacial acetic acid as a developing agent and using the thin layer chromatography. By adopting the method, the quality of the main components including the Chinese ephedra and the platycodon root, which cause problems easily, in a prescription is effectively controlled, so that the quality of the wind-cold cold granules is better and more comprehensively reflected, fake and shoddy wind-cold cold granules produced by illegal manufacturers can be effectively detected and identified, and then the safety and effectiveness of mass medication are ensured.

Description

technical field [0001] The invention relates to a detection method for cold medicine, in particular to a quality detection method for Fenghanmao granules, which belongs to the technical field of pharmaceuticals. Background technique [0002] Fenghanmao granule is a variety recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The standard number is WS3-B-0045-89. , bitter almond, platycodon grandiflorum, licorice, and dried ginger are composed of eleven traditional Chinese medicines. It is a traditional Chinese medicine compound granule. It has the effects of relieving the surface and sweating, and dispelling wind and cold. Clinically used for cold body fever, headache, cough, nasal congestion, runny nose. It is a commonly used drug on the market for treating respiratory diseases such as cold and fever, headache, cough, nasal congestion, and runny nose. [0003] However, the existing standards do not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
Inventor 钟茂团吴诗慧黎勇刘扬川
Owner SICHUAN FENGCHUN PHARMA
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