Method for establishing machin hyperlipidemia and atherosclerosis model

A technology for atherosclerosis and hyperlipidemia, applied in animal husbandry and other directions, can solve the problems of development failure, adverse reactions, endangering the life safety of drug users, etc., and achieve the effect of inducing increased blood lipid levels
CN103299950AInactive Publication Date: 2013-09-18苏州西山中科实验动物有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
苏州西山中科实验动物有限公司
Publication Date
2013-09-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for establishing a machin hyperlipidemia and atherosclerosis model. The method comprises the following steps of (1) preparing a plurality of machin as candidates; (2) detecting four biochemical indexes of the blood of the candidate machin such as TC,TG, HDL-C and LDL-C; (3) selecting the machin for the modeling to be grouped; (4) adding more than one of 5 to 20 percent of yolk powder, 5 to 20 percent of lard oil and 0.5 to 2 percent of cholesterol on the basis of 58 to 89.5 percent of basic feed according to the formula of high-fat feed by weight percent to prepare a plurality of formulas, respectively utilizing one formula to feed one group of machin, and determining an optimal formula according to the variation of the biochemical indexes; (5) completing the establishment of a hyperlipidemia model; and (6) detecting relevant indexes of the model. Through the method for establishing the machin hyperlipidemia and atherosclerosis model, the optimally selected high-fat feed can successfully induce the increase of the blood fat of the machin and is very stable.
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Description

technical field

[0001] The invention relates to a method for establishing a model of hyperlipidemia and atherosclerosis in cynomolgus monkeys, which comprises a high-fat feed capable of inducing hyperlipidemia, and belongs to the category of non-human primate experimental animal disease models. Background technique

[0002] Hyperlipidemia refers to abnormal fat metabolism or operation that makes one or more lipids in plasma higher than normal. Hyperlipidemia is a systemic disease, refers to blood cholesterol (TC) and / or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low, modern medicine is called dyslipidemia. Lipids are insoluble or slightly soluble in water and must be combined with proteins to exist in the form of lipoproteins. Therefore, hyperlipoproteinemia is usually present. Currently recognized hyperlipidemia, including hypercholesterolemia, hypertriglyceridemia and complex hyperlipidemia. The damage to the body of the disease ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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