Method for establishing machin hyperlipidemia and atherosclerosis model

A technology for atherosclerosis and hyperlipidemia, applied in animal husbandry and other directions, can solve the problems of development failure, adverse reactions, endangering the life safety of drug users, etc., and achieve the effect of inducing increased blood lipid levels

Inactive Publication Date: 2013-09-18
苏州西山中科实验动物有限公司
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Problems solved by technology

[0005] However, due to differences in animal races, small animals and currently widely used rodent experimental animal models cannot better reflect the efficacy of drugs on humans.
At present, the preclinical pharmacodynamic studies of many drugs cannot better reflect the efficacy or safety of the drug, resulting in the failure of the development of many drugs after spending a lot of research costs, or serious adverse reactions after clinical application, thus endangering the drug use. life safety of the crowd

Method used

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  • Method for establishing machin hyperlipidemia and atherosclerosis model
  • Method for establishing machin hyperlipidemia and atherosclerosis model

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Embodiment 1

[0029] A method for establishing a cynomolgus monkey model of hyperlipidemia and atherosclerosis, the specific implementation steps are as follows:

[0030] 1) Screening of test monkeys:

[0031] First, 100 middle-aged and elderly cynomolgus monkeys with healthy body and active diet were selected from the monkey population.

[0032] 2) Detection of blood TC, TG, HDL-C, LDL-C and other indicators:

[0033] After quarantine and adaptation to breeding, blood was collected from the saphenous vein, and blood TC, TG, HDL-C, and LDL-C biochemical indicators were tested once a week for 3 consecutive times. With the values ​​of TC, TG and LDL-C not higher than 2 times of normal monkeys as the standard, 36 test monkeys were selected.

[0034] The adoption of this strategy is based on the following considerations:

[0035] First of all, the purpose of selecting a monkey with a strong physique is to ensure that the diet of the monkey is normal, because the induction method involved in ...

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Abstract

The invention provides a method for establishing a machin hyperlipidemia and atherosclerosis model. The method comprises the following steps of (1) preparing a plurality of machin as candidates; (2) detecting four biochemical indexes of the blood of the candidate machin such as TC,TG, HDL-C and LDL-C; (3) selecting the machin for the modeling to be grouped; (4) adding more than one of 5 to 20 percent of yolk powder, 5 to 20 percent of lard oil and 0.5 to 2 percent of cholesterol on the basis of 58 to 89.5 percent of basic feed according to the formula of high-fat feed by weight percent to prepare a plurality of formulas, respectively utilizing one formula to feed one group of machin, and determining an optimal formula according to the variation of the biochemical indexes; (5) completing the establishment of a hyperlipidemia model; and (6) detecting relevant indexes of the model. Through the method for establishing the machin hyperlipidemia and atherosclerosis model, the optimally selected high-fat feed can successfully induce the increase of the blood fat of the machin and is very stable.

Description

technical field [0001] The invention relates to a method for establishing a model of hyperlipidemia and atherosclerosis in cynomolgus monkeys, which comprises a high-fat feed capable of inducing hyperlipidemia, and belongs to the category of non-human primate experimental animal disease models. Background technique [0002] Hyperlipidemia refers to abnormal fat metabolism or operation that makes one or more lipids in plasma higher than normal. Hyperlipidemia is a systemic disease, refers to blood cholesterol (TC) and / or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low, modern medicine is called dyslipidemia. Lipids are insoluble or slightly soluble in water and must be combined with proteins to exist in the form of lipoproteins. Therefore, hyperlipoproteinemia is usually present. Currently recognized hyperlipidemia, including hypercholesterolemia, hypertriglyceridemia and complex hyperlipidemia. The damage to the body of the disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/00
Inventor 刘春亮夏玉叶王毅高超曹欢杨艳玲李蓉赵凡钱炜东杨磊郑霞
Owner 苏州西山中科实验动物有限公司
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