Anti-mesothelin antibodies and immunoconjugates

A technology of immunoconjugates and mesothelin, applied in the direction of antibodies, anti-animal/human immunoglobulins, anti-receptors/cell surface antigens/cell surface determinant immunoglobulins, etc.
CN103347897BActive Publication Date: 2016-11-30F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Publication Date
2016-11-30

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Abstract

The invention provides anti-mesothelin antibodies and immunoconjugates and methods of use thereof.
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Description

[0001] related application

[0002] This application claims the benefit under 35 USC 119(e) of US Provisional Application No. 61 / 459,962, filed December 20, 2010, the contents of which are incorporated herein by reference.

[0003] sequence listing

[0004] This application, containing a Sequence Listing, has been filed via EFS-WEB in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on November 29, 2011, is named P4532R1-WO.txt and is 53,169 bytes in size. field of invention

[0005] The present invention relates to anti-mesothelin antibodies and immunoconjugates and methods of use thereof. Background of the invention

[0006] Mesothelin is a cell surface glycoprotein whose expression is usually restricted to the mesothelium (peritoneum, pericardium, and pleura). However, mesothelin is significantly overexpressed in a variety of tumor types. Mesothelin interacts with MUC16 (also known as CA125), a mucin-like glycoprotein prev...

Claims

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