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Anti-mesothelin antibodies and immunoconjugates

A technology of immunoconjugates and mesothelin, applied in the direction of antibodies, anti-animal/human immunoglobulins, anti-receptors/cell surface antigens/cell surface determinant immunoglobulins, etc.

Active Publication Date: 2016-11-30
F HOFFMANN LA ROCHE & CO AG
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, mesothelin is significantly overexpressed in multiple tumor types

Method used

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  • Anti-mesothelin antibodies and immunoconjugates
  • Anti-mesothelin antibodies and immunoconjugates
  • Anti-mesothelin antibodies and immunoconjugates

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Embodiment Construction

[0072] I. Definition

[0073] For the purposes herein, an "acceptor human framework" refers to a framework comprising a variable light chain (VL) domain or a variable heavy domain (VH) framework derived from a human immunoglobulin framework or a human consensus framework as defined below. frame of the amino acid sequence. An acceptor human framework "derived" from a human immunoglobulin framework or a human consensus framework may comprise its identical amino acid sequence, or it may contain amino acid sequence changes. In some embodiments, the number of amino acid changes is 10 or less, 9 or less, 8 or less, 7 or less, 6 or less, 5 or less, 4 or less, 3 or less , or 2 or less. In some embodiments, the VL acceptor human framework is identical in sequence to a VL human immunoglobulin framework sequence or a human consensus framework sequence.

[0074] "Affinity" refers to the strength of the sum of all non-covalent interactions between a single binding site of a molecule (eg...

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Abstract

The invention provides anti-mesothelin antibodies and immunoconjugates and methods of use thereof.

Description

[0001] related application [0002] This application claims the benefit under 35 USC 119(e) of US Provisional Application No. 61 / 459,962, filed December 20, 2010, the contents of which are incorporated herein by reference. [0003] sequence listing [0004] This application, containing a Sequence Listing, has been filed via EFS-WEB in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on November 29, 2011, is named P4532R1-WO.txt and is 53,169 bytes in size. field of invention [0005] The present invention relates to anti-mesothelin antibodies and immunoconjugates and methods of use thereof. Background of the invention [0006] Mesothelin is a cell surface glycoprotein whose expression is usually restricted to the mesothelium (peritoneum, pericardium, and pleura). However, mesothelin is significantly overexpressed in a variety of tumor types. Mesothelin interacts with MUC16 (also known as CA125), a mucin-like glycoprotein prev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K16/30A61K47/48A61K39/395A61P35/00
Inventor M.丹尼斯S.J.斯凯尔斯S.D.斯潘塞Y.张
Owner F HOFFMANN LA ROCHE & CO AG
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