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Forming method of granules for regulating qi and reducing phlegm

A technology for forming granules, smoothing gas and dissolving phlegm, applied in the directions of active ingredients of heterocyclic compounds, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of difficult drying, large consumption, difficult forming of granules, etc., so as to improve product yield and improve The effect of uniformity and improved molding rate

Active Publication Date: 2013-10-23
ZHONGXING PHARM CO LTD JIANGSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Shunqi Huatan Qing Ointment itself is highly hygroscopic, easy to absorb moisture, and difficult to dry. If the traditional drying method is directly used to prepare granules, the granules are not easy to shape, resulting in low yield and high consumption of granules.
The highest yield of Shunqi Huatan Granules can only reach about 80%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: A method for forming Shunqi Huatan Granules. The components of Shunqi Huatan Granules are clear ointment powder: dextrin: ethanol in a weight ratio of 1:2.5:0.2, and ethanol is 95% by volume The prescription of ethanol and clear ointment powder is Vitex japonica: pine cone: plantain: licorice in a ratio of 1300: 1566.7: 1041.7: 130 by weight.

[0014] The first step, prepare clear cream powder:

[0015] 1. Weigh the amount of Siweijing medicinal materials required for the production of 125 bags (5g per bag) of Shunqi Huatan Granules according to the above-mentioned formula of clear cream powder, and set aside;

[0016] Decoction: Put the above four flavors into the extraction tank respectively. For the first decoction, add water 8 times the amount of medicinal materials, heat to boil, and keep boiling for 3 hours. The extract is filtered through a 200-mesh filter and then enters the sedimentation tank; for the second decoction, add water 4 times the amount o...

Embodiment 2

[0028] Embodiment 2: basically the same as Example 1, the difference is that clear cream powder: dextrin: ethanol is proportioned by weight 1: 2.2: 0.3, and the drying time in the third step is 3 hours. The yield of Shunqi Huatan Granules was 94.6%.

Embodiment 3

[0029] Embodiment 3: It is basically the same as Embodiment 1, except that the clear paste powder: dextrin: ethanol is proportioned in a weight ratio of 1: 2: 0.1. The yield of Shunqi Huatan Granules was 94.2%.

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PUM

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Abstract

The invention discloses a forming method of granules for regulating qi and reducing phlegm. The forming method comprises the following steps: drying clear paste prepared from negundo chastetree fruit, pinecone, plantain herb and liquorice to obtain a dry clear paste substance, then crushing to obtain clear paste powder; weighing aminophylline and chlorpheniramine maleate, evenly mixing with a part of dextrin by using a running-in process; mixing the weighed clear paste powder, residue dextrin and the running-in mixture with ethanol and stirring to prepare a soft material; primarily sieving, pelletizing, mixing the prepared granules with ethanol and stirring to prepare the soft material; and sieving, pelletizing, drying by microwaves, and forming granules by a screen, so as to prepare the granules. The forming method has the advantages that the clear paste is dried by the microwaves and crushed into superfine powder to prepare the clear paste powder; the blending effect of the clear paste powder and the dextrin is improved and a secondary pelletizing technology is adopted so as to prepare the soft material; the soft material is dried and prepared into granules, so that the uniformity of the product is improved; and the forming rate of the granules is also improved. Thus, the product yield is improved; consumption of the clear paste powder and the dextrin is reduced; and the yield of the granules for regulating qi and reducing phlegm is improved to about 95%.

Description

technical field [0001] The invention relates to a method for preparing medicines, in particular to a method for forming Shunqi Huatan granules. Background technique [0002] Shunqi Huatan Granule is a medicine for relieving cough, relieving asthma, and smoothing Qi and reducing phlegm. It is composed of four traditional Chinese medicines of Vitex japonica, pine cone, plantain, and licorice, and two western medicines of chlorpheniramine maleate and aminophylline. It treats both symptoms and root causes , the curative effect is exact. It is suitable for symptoms such as upper flu, acute and chronic bronchitis, cough with phlegm, chest tightness and shortness of breath. [0003] The above six herbs, Vitex japonica, pine cone, plantain, and licorice, are decocted twice with water, 3 hours each time, combined with the decoction, left to settle, filtered, and the supernatant is concentrated to a relative density of 1.24 ( 80°C) clear paste; aminophylline and chlorpheniramine mal...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/16A61K31/4402A61K31/522
Inventor 徐冰王长和
Owner ZHONGXING PHARM CO LTD JIANGSU
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