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Near infrared transmitted spectrum detection method of naringin and/or neohesperidin

A near-infrared spectroscopy and neohesperidin technology, applied in the field of near-infrared spectroscopy detection of naringin and/or neohesperidin content, can solve the problems of long analysis time, difficult on-line monitoring, complex pretreatment, etc. Improve forecast accuracy, improve stability, and reduce instrument noise effects

Active Publication Date: 2013-11-06
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the contents of naringin and neohesperidin in Fructus aurantium from different plant sources varied greatly
[0003] At present, the content determination of naringin and / or neohesperidin is mainly high-performance liquid chromatography (HPLC method), which has the characteristics of accurate quantification and good reproducibility, but generally requires complicated pretreatment and long analysis time. It is difficult to effectively monitor its content online during the production process

Method used

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  • Near infrared transmitted spectrum detection method of naringin and/or neohesperidin
  • Near infrared transmitted spectrum detection method of naringin and/or neohesperidin
  • Near infrared transmitted spectrum detection method of naringin and/or neohesperidin

Examples

Experimental program
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Effect test

Embodiment 1

[0070] Weigh 700g of Citrus aurantium medicinal material, add NaOH in purified water to adjust to pH=9, add 15 times the amount into a 10L round bottom flask, add an electric heating mantle and cook until it boils slightly for one hour, take 10mL of the extract every 10min for decoction, A total of 6 samples were obtained, and the extract sample solution was filtered with a 0.45 μm microporous membrane.

[0071] Adopt BRUKER TENSOR37 type Fourier transform near-infrared spectrometer (equipped with quantitative analysis software OPUS6.5, German Bruker company), carry out near-infrared spectrum analysis to the obtained 6 samples, adopt the transmission detector of the instrument, put the sample solution into Scan the spectrum in a 1mm quartz cuvette, the scanning wavelength range is naringin at 11995.6-7498.2cm -1 、6101.9-5446.2cm -1 And 4601.5-4246.7cm -1 Within the three bands, neohesperidin is at 11995.6-5446.2cm -1 And 4601.5-4246.7cm -1 Within the band, the number of sc...

Embodiment 2

[0076] Weigh 500g of Aurantium citrus medicinal material, add NaOH to the purified water to adjust the pH to 12, add 5 times the amount into a 10L round bottom flask, add an electric heating mantle and cook until it boils slightly for one hour, and take 10mL of the extract every 20min for decoction, The extraction was repeated four times, and 9 samples were taken, and the sample solution of the extract was filtered with a 0.45 μm microporous membrane.

[0077] Adopt BRUKER TENSOR37 type Fourier transform near-infrared spectrometer (equipped with quantitative analysis software OPUS6.5, German Bruker company), carry out near-infrared spectrum analysis to the obtained 9 samples, adopt the transmission detector of the instrument, put the sample solution into Scan the spectrum in a 1mm quartz cuvette, the scanning wavelength range is naringin at 11995.6-7498.2cm -1 、6101.9-5446.2cm -1 And 4601.5-4246.7cm -1Within the three bands, neohesperidin is at 11995.6-5446.2cm -1 And 4601....

Embodiment 3

[0082] Weigh 600g of Citrus aurantium medicinal material, add NaOH to the purified water to adjust to pH = 11, add 10 times the amount into a 10L round bottom flask, add an electric heating mantle and cook until it boils slightly for one hour, and take 10mL of the extract every 20 minutes for decoction, The extraction was repeated three times, and a total of 9 samples were obtained, and the sample solution of the extract was filtered with a 0.45 μm microporous membrane.

[0083] Adopt BRUKER TENSOR37 type Fourier transform near-infrared spectrometer (equipped with quantitative analysis software OPUS6.5, German Bruker company), carry out near-infrared spectrum analysis to the obtained 9 samples, adopt the transmission detector of the instrument, put the sample solution into Scan the spectrum in a 1mm quartz cuvette, the scanning wavelength range is naringin at 11995.6-7498.2cm -1 、6101.9-5446.2cm -1 And 4601.5-4246.7cm -1 Within the three bands, neohesperidin is at 11995.6-54...

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Abstract

The invention provides a near infrared transmitted spectrum detection method of naringin and / or neohesperidin. The near infrared transmitted spectrum detection method comprises the following steps of 1, adding alkaline water into traditional Chinese medicines containing naringin and / or neohesperidin, wherein the amount of the alkaline water is 5-15 time the amount of the traditional Chinese medicines, carrying out decoction to obtain a decoction, and carrying out filtration to obtain a liquid to be detected, 2, carrying out scanning of the liquid to be detected by a near-infrared spectrograph to obtain near-infrared spectroscopy data, and 3, determining naringin and / or neohesperidin content of the detected liquid by a made calibration model.

Description

technical field [0001] The invention belongs to the fields of medicine and chemistry, and in particular relates to a near-infrared spectrum detection method for the content of naringin and / or neohesperidin in the extraction process of citrus aurantium or citrus aurantium and its application. The method can not only detect the contents of naringin or neohesperidin separately, but also detect the contents of naringin and neohesperidin simultaneously. Background technique [0002] Fructus Aurantii Immaturus and Fructus Aurantii are the dry immature and ripe fruits of the Rutaceae plant lime (Citrus aurantium L) and its cultivars or sweet orange (Citrus sinensis Osbeck), respectively. Its chemical components are flavonoids, alkaloids, volatile oils, etc. Among them, flavonoids such as naringin, neohesperidin, and hesperidin play the main pharmacological role. Pharmacological studies have shown that Fructus Aurantii has different regulatory effects on gastrointestinal tract, car...

Claims

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Application Information

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IPC IPC(8): G01N21/35
Inventor 叶正良许崇瑶李德坤周大铮
Owner TIANJIN TASLY ZHIJIAO PHARMA
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