Diterpene acid for preventing Coxsackie virus, preparation method, pharmaceutical composition, and applications thereof

A technology for coxsackie virus and composition, which is applied in the directions of antiviral agents, separation/purification of carboxylic acid compounds, medical preparations containing active ingredients, etc., and can solve problems such as no specific drugs

Active Publication Date: 2013-12-18
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the infection caused by Coxsackie virus, there is no specific drug for treatment so far, so it is necessary to develop a drug with specific anti-Coxsackie virus

Method used

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  • Diterpene acid for preventing Coxsackie virus, preparation method, pharmaceutical composition, and applications thereof
  • Diterpene acid for preventing Coxsackie virus, preparation method, pharmaceutical composition, and applications thereof
  • Diterpene acid for preventing Coxsackie virus, preparation method, pharmaceutical composition, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Separation and structural characterization of abietane-type diterpene acids (1-13)

[0040]10kg of the root and root bark of Maple japonica, crushed, and reflux extracted with 95% EtOH (ethanol, 50L) for 3 times, 2 hours each time. The extract was concentrated under reduced pressure to obtain 900 g of extract, which was dissolved in methanol, mixed with 2 kg of diatomaceous earth, and extracted with petroleum ether, ethyl acetate and methanol in turn to obtain 47 g of ethyl acetate. The ethyl acetate part was chromatographed on a silica gel column (200-300 mesh), and eluted with petroleum ether: acetone (100:0 to 100:25), dichloromethane: methanol (100:4 to 100:25), according to thin The combined fractions were identified by layer plate detection, and five fractions Y1-Y5 were obtained. Fraction Y1 (2.3 g) was separated and purified by gel column (dichloromethane) to obtain five fractions Y1-1-Y1-5. Compound 7 (200 mg) was obtained after Y1-2 (0.5 g) was pur...

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Abstract

The invention relates to anti Coxsackie virus effective components, which are separated from illicium jiadifengpi B.N.Chang, and comprise six novel abietane diterpene acid (1 to 6) compounds and seven known abietane diterpene acid (7 to 13) compounds, pharmacy-acceptable salts thereof, a preparation method thereof, a pharmaceutical composition containing the compounds, and applications of the compounds in the preparation of drugs for preventing Coxsackie virus.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular, the invention relates to a class of abietane-type diterpene acid compounds (1-13), including new compounds (1-6) and known compounds (7-13), which A pharmacodynamically acceptable salt, a preparation method thereof, a pharmaceutical composition containing the compound, and an application of the compound in preparing anti-Coxsackie virus preparations. Background technique [0002] Coxsackieviruses belong to the Enterovirus genus of the Picornaviridae family. The virus genome is a single-stranded positive-strand RNA virus, which is divided into type A and type B according to its biological characteristics. It is a common type of virus that infects the human body through the respiratory tract and digestive tract, especially type B virus, which can cause myocarditis after infection , Coxsackie virus can also cause meningitis, mild paralysis, pleuritic pain, intercostal pain, respira...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C62/32C07C62/38C07C61/39C07C61/29C07C51/42A61K31/192A61K31/191A61K31/19A61P31/14
Inventor 庾石山蒋建东张贵杰李玉环屈晶马双刚刘云宝李勇
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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