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paste bone cement

A monomer, free radical technology, applied in prosthesis, surgery, tissue regeneration, etc., can solve the problem of the contribution of the mechanical stability of pasty cement

Inactive Publication Date: 2017-03-01
HERAEUS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, one problem is that the cross-linked polymer particles used so far also contribute to the mechanical stability of the cured paste cement

Method used

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Embodiment Construction

[0014] The present invention is based on the discovery that well-formed and shaped bone cements can be prepared by using particulate inorganic calcium salts from molecular sieve fractions smaller than 63 µm (according to DIN 66165-1 / -2) With methyl methacrylate bone cement, that was an accident. The surprise is that the hitherto customary crosslinked polymer particles which are insoluble in methacrylate monomers can be completely or partially replaced by particulate inorganic calcium salts. Inorganic calcium salts are considerably cheaper than crosslinked polymer particles and can thus be used economically and advantageously in the production of pasty polymethylmethacrylate bone cements. Surprisingly, it was found that calcium carbonate, in particular from molecular sieve fractions smaller than 63 μm, is particularly suitable as filler.

[0015] Inorganic calcium salts such as calcium carbonate have relatively low hardness. Therefore, calcium carbonate (calcite) is character...

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Abstract

The present invention relates to a polymer comprising at least one monomer for free radical polymerization, at least one polymer soluble in said at least one monomer for free radical polymerization, and at least one poorly soluble or insoluble in said at least one monomer for free radical polymerization. A paste of at least one filler for free-radically polymerized monomers, wherein the filler is a particulate inorganic calcium salt comprising the following properties i) and ii): i) at least 90 wt% of the particulate inorganic calcium salt has A particle size of less than 63 µm as determined by molecular sieve analysis; ii) a solubility of particulate inorganic calcium salts in water of less than 8.5 g / L at 20°C. The invention also relates to a kit, paste or a paste prepared from a kit according to the invention for mechanical fixation of joint prostheses, covering of skull defects, filling of bone cavities, femuroplasty, vertebroplasty, kyphoplasty . Use for producing a spacer or for producing a carrier material for topical antibiotic therapy, and a shaped body.

Description

technical field [0001] The invention relates to a paste, kit, paste or paste prepared from a kit for mechanical fixation of joint prostheses, for covering skull defects, for filling bone cavities, femuroplasty, vertebroplasty, kyphoplasty for surgery, for the preparation of spacers or for the preparation of carrier materials for topical antibiotic therapy, and for form bodies. Background technique [0002] Traditional polymethylmethacrylate bone cement (PMMA bone cement) has been around for decades and is based on the breakthrough work of Sir Charnley (Charnley, J.: " Anchorage of the femoral head prosthesis of the shaft of the femur "; J. Bone Joint Surg. 42(1960) 28-30). Since then, the basic structure of PMMA bone cement has remained unchanged. PMMA bone cement consists of a liquid monomer component and a powder component. The monomer component is usually Contains (i) a monomer, methyl methacrylate, and (ii) an activator (eg, N,N-dimethyl-p-toluidine) dissolved therein...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L27/44A61L24/06A61K47/32C08F4/00C08F20/10
CPCA61L27/46A61L24/0073A61L2430/02A61L24/0084A61L24/0089C08L33/08A61L24/043
Inventor S.福格特
Owner HERAEUS MEDICAL
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