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Traditional Chinese medicine composition and extract thereof for treating ankylosing spondylitis

An ankylosing spondylitis and composition technology, which can be used in drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems of high price of immunosuppressants, unfavorable medication safety, large side effects, etc., and can inhibit swelling of ankle joints. , low side effects, low cost effect

Inactive Publication Date: 2017-08-04
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, traditional anti-inflammatory drugs often have limited curative effects, although immunosuppressants have relatively good curative effects but are expensive, and other types of drugs except natural plants have large side effects, which is not conducive to drug safety.

Method used

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  • Traditional Chinese medicine composition and extract thereof for treating ankylosing spondylitis
  • Traditional Chinese medicine composition and extract thereof for treating ankylosing spondylitis
  • Traditional Chinese medicine composition and extract thereof for treating ankylosing spondylitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1. Composition of traditional Chinese medicine composition for treating ankylosing spondylitis

[0016] Component Composition 1 Composition 2 Composition 3 Composition 4 Composition 5 Salvia (g)196206216226236 Notoginseng (g)6459545740 Angelica (g)12010410810296 Achyranthes (g)140150162170180 Pueraria lobata (g) 196206216226236

Embodiment 2

[0017] Example 2. Preparation of extract of traditional Chinese medicine composition for the treatment of ankylosing spondylitis

[0018] Respectively according to the composition of compositions 1 to 5 given in Example 1, first take 4 medicinal materials except Panax notoginseng, add water equivalent to 10 times the total weight of the medicinal materials, soak for 30 minutes, decoct for 2 hours, filter, and collect the filtrate; Then add water equivalent to 10 times the total weight of the medicinal materials to the medicinal residue, decoct for 2h, filter, and collect the filtrate; add the medicinal residue with 8 times the total weight of the medicinal materials, decoct for 1.5h, filter, and collect the filtrate; combine The three-time filtrate was concentrated under reduced pressure at 70°C to a relative density of 1.38, and then notoginseng powder was added and mixed well to prepare an extract of the Chinese medicine composition.

Embodiment 3

[0019] Example 3. Preparation of Chinese medicinal preparations for the treatment of ankylosing spondylitis

[0020] Mix the extract of the traditional Chinese medicine composition prepared in Example 2 with the sucrose powder at a weight ratio of 1:2, and then add 0.5 to 1 times the weight of the mixture (depending on the granulation situation), mix well, No. sieve granulation, drying at 60°C, granulation on No. 1 sieve, drying to dry granules, bagging to obtain granules.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating ankylosing sondylitis and an extractive thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 196-236 parts of radix salviae miltiorrhizae, 40-64 parts of panax pseudoginseng, 96-120 parts of Chinese angelica, 140-180 parts of achyranthes bidentata and 196-236 parts of radix puerariae; the extractive can be further prepared from the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention is unique in compatibility, accurate in curative effect, low in toxic and side effects and low in cost, and animal experiment results show that the traditional Chinese medicine composition can obviously restrain adjuvant type ankle joint swelling of rats, ear swelling of mice caused by croton oil, writhing response of mice caused by acetic acid and cotton ball granulation tissue hyperplasia of rats, and has the good effects of anti-inflammatory and analgesia, therefore, a better alternative medicine is provided for clinic treatment of ankylosing sondylitis.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition and an extract thereof. Background technique [0002] Ankylosing spondylitis (anky losing spondy litis AS) is a systemic chronic progressive immune disease of unknown cause that mainly invades the axial joints. The pathogenesis may be related to genetics, autoimmune disorders, infections and endocrine disorders. After the illness, the patient's self-care and work ability will be greatly affected, and it will also bring a heavy burden to the family and society. [0003] Currently, there is no specific and ideal treatment for this disease. There are five main types of drugs used for treatment: non-steroidal anti-inflammatory drugs, slow-acting anti-rheumatic drugs, immunosuppressants, glucocorticoids and natural plants; the main therapeutic mechanisms are anti-inflammatory / anti-inflammatory and analgesic, and immune suppressio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P37/02A61P19/02A61P29/00
Inventor 晋献春何威邢茂胡雪莲张恩娟李曼
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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