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A pharmaceutical composition for treating Alzheimer's disease, its preparation method and application

A technology for Alzheimer's disease and a composition, which can be applied in the field of medicine and can solve problems such as no treatment for Alzheimer's disease.

Active Publication Date: 2016-08-17
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Currently, the combination of Cortex Phellodendron and Radix Paeoniae Rubra is mostly used to treat acute severe hepatitis, prostatitis, and dysentery. There is no relevant report on the treatment of Alzheimer's disease.

Method used

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  • A pharmaceutical composition for treating Alzheimer's disease, its preparation method and application
  • A pharmaceutical composition for treating Alzheimer's disease, its preparation method and application
  • A pharmaceutical composition for treating Alzheimer's disease, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] Embodiment 1 hard capsule

[0157] Prescription: Phellodendron 10g, Radix Paeoniae Rubra 1000g

[0158] Preparation method: add 10 times the amount of 75% ethanol to soak Cortex Phellodendri and Radix Paeoniae Rubra, soak for 2 hours, heat and reflux to extract twice, each time for 2 hours, filter or centrifuge, combine the two extracts to obtain the alcohol extract, concentrate under reduced pressure and serve D-101 macroporous resin is purified, vacuum-dried, crushed into fine powder, added appropriate amount of starch, granulated with polyacrylic acid resin, packed into capsules, and made into 1000 capsules.

[0159] Indications: treatment of Alzheimer's disease.

[0160] Dosage: Take orally, 2-3 times a day, 2-3 capsules each time.

Embodiment 2

[0161] Example 2 tablet

[0162] Prescription: Phellodendron 400g, Radix Paeoniae Rubra 400g

[0163] Preparation method: Cortex Phellodendri and Radix Paeoniae Rubra, soaked in 8 times the amount of 50% ethanol for 1 hour, heated and refluxed for 1 hour, filtered or centrifuged to obtain the alcohol extract, concentrated under reduced pressure, purified by D-101 macroporous resin, vacuum Dry, pulverize into fine powder, add magnesium stearate, mix evenly and press into 1000 tablets, to get final product.

[0164] Indications: treatment of Alzheimer's disease.

[0165] Dosage: Take orally, 2 to 3 times a day, 2 to 3 tablets each time.

Embodiment 3

[0166] Example 3 Granules

[0167] Prescription: Phellodendron 500g, Radix Paeoniae Rubra 5g

[0168] Preparation method: Cortex Phellodendri and Radix Paeoniae Rubra, soaked in 10 times the amount of 95% ethanol for 3 hours, heated and refluxed for 4 times, 3 hours each time, filtered or centrifuged, combined 4 times to obtain the alcohol extract, concentrated under reduced pressure and used D-101 macroporous resin is purified, dried in vacuum, crushed into fine powder, added with appropriate amount of sucrose and starch, or added with appropriate amount of dextrin, made into granules, dried, added with appropriate amount of ethyl cellulose, granulated, and obtained.

[0169] Indications: treatment of Alzheimer's disease.

[0170] Usage and dosage: take orally, 2 to 3 times a day, 2 to 4g each time.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating Alzheimer disease as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 1-100 parts of Cortex Phellodendri (Phellodendron chinense and / or Phellodendron amurense), and 1-100 parts of Radix Paeoniae Rubra (Paeonia lactiflora and / or Paeonia veitchii). The invention also discloses a preparation method of the pharmaceutical composition. The pharmaceutical composition can be used for preparing medicaments for treating Alzheimer disease.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating Alzheimer's disease, a preparation method and application thereof. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. Those with onset before the age of 65 are called Alzheimer's disease; those with onset after the age of 65 are called senile dementia. [0003] There are 24.3 million people living with dementia in the world, and 4.6 million new cases are added every year, almost one person suffers from dementia every 7 seconds. Two-thirds of the world's elderly population aged 65 and above live in developing countries...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P25/28
Inventor 萧伟陶晓倩李娜曹亮孟兆青杨彪孙林李兆亮胡玉梅王俨如邓奕王振中丁岗王跃生
Owner JIANGSU KANION PHARMA CO LTD
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