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A kind of pharmaceutical composition with neuroprotective effect and preparation method

A technology for neuroprotection and composition, applied in the field of medicine, can solve the problems of high liver toxicity and limitations

Active Publication Date: 2019-05-14
吉林天力泰药业有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, tacrine has been gradually replaced due to its high liver toxicity, while huperzine A has not been approved by the FDA, and its application abroad is limited.

Method used

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  • A kind of pharmaceutical composition with neuroprotective effect and preparation method
  • A kind of pharmaceutical composition with neuroprotective effect and preparation method
  • A kind of pharmaceutical composition with neuroprotective effect and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075]1. Take 75 parts by weight of ginseng, 150 parts by weight of Radix Astragali, 150 parts by weight of Scutellaria barbata, 334 parts by weight of Evergreen, 67 parts by weight of Polygonum cuspidatum, 75 parts by weight of Salvia miltiorrhiza, 150 parts by weight of Hedyotis diffusa, and 75 parts by weight of Curcuma part, 30 parts by weight of scorpion, and 30 parts by weight of centipede.

[0076] 2. Mix the ginseng, astragalus, and banzhilian taken in step 1, soak in 10 times the amount of water for 2 hours according to the mass volume ratio (g / ml), then heat and decoct 3 times, 2 hours each time, filter, and combine The filtrate is concentrated to a dry cream, crushed to obtain a dry cream powder extracted with water;

[0077] 3. Mix Dieffenbachia tigereye, Polygonum cuspidatum, Salvia miltiorrhiza, and Hedyotis diffusa taken in step 1, heat and reflux extract with 10 times the amount of 70% ethanol according to the mass volume ratio (g / ml) for 3 times, each time for...

Embodiment 2

[0081] 1. Take 120 parts by weight of ginseng, 90 parts by weight of astragalus, 190 parts by weight of Scutellaria barbata, 140 parts by weight of evergreen, 115 parts by weight of knotweed, 30 parts by weight of salvia miltiorrhiza, 250 parts by weight of Hedyotis diffusa, and 30 parts by weight of curcuma , 50 parts by weight of a centipede, and 10 parts by weight of a scorpion;

[0082] 2. Mix the ginseng, astragalus, and banzhilian taken in step 1, soak in 10 times the amount of water for 2 hours according to the mass volume ratio (g / ml), then heat and decoct 3 times, 2 hours each time, filter, and combine The filtrate is concentrated to a dry cream, crushed to obtain a dry cream powder extracted with water;

[0083] 3. Mix Dieffenbachia tigereye, Polygonum cuspidatum, Salvia miltiorrhiza, and Hedyotis diffusa taken in step 1, heat and reflux extract with 10 times the amount of 70% ethanol according to the mass volume ratio (g / ml) for 3 times, each time for 1 hour, and fi...

Embodiment 3

[0087] 1. Take 30 parts by weight of ginseng, 190 parts by weight of astragalus, 90 parts by weight of Scutellaria barbata, 560 parts by weight of evergreen, 28 parts by weight of knotweed, 125 parts by weight of salvia miltiorrhiza, 65 parts by weight of Hedyotis diffusa, and 120 parts by weight of curcuma , 10 parts by weight of centipede, and 50 parts by weight of scorpion;

[0088] 2. Mix the ginseng, astragalus, and banzhilian taken in step 1, soak in 10 times the amount of water for 2 hours according to the mass volume ratio (g / ml), then heat and decoct 3 times, 2 hours each time, filter, and combine The filtrate is concentrated to a dry cream, crushed to obtain a dry cream powder extracted with water;

[0089] 3. Mix Dieffenbachia tigereye, Polygonum cuspidatum, Salvia miltiorrhiza, and Hedyotis diffusa taken in step 1, heat and reflux extract with 10 times the amount of 70% ethanol according to the mass volume ratio (g / ml) for 3 times, each time for 1 hour, and filter ...

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Abstract

The invention discloses a medicinal composition with a neuroprotective effect and a preparing method thereof. Radix ginseng, radix astragali in parts by weight, herba scutellariae barbatae, ornithogalum saundersiae, rhizoma polygoni cuspidati, radix salviae miltiorrhizae, herba hedyotidis diffusae, radix curcumae, scolopendra and scorpion are utilized as raw materials. Water extract powder of the radix ginseng, the radix astragali and the scutellariae barbatae herb, alcohol extract powder of the ornithogalum saundersiae, the rhizoma polygoni cuspidati, the radix salviae miltiorrhizae and the herba hedyotidis diffusae, radix curcumae powder, scolopendra powder and scorpion powder are mixed to be manufactured into the medicinal composition. Pharmacological testing shows that the medicinal composition has the neuroprotective effect, is suitable for preventing and curing Alzheimer's disease and is obvious in curing effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition with neuroprotective effect and a preparation method. Background technique [0002] Alzheimer's disease (AD) is a primary central nervous system degenerative disease characterized by memory loss and cognitive dysfunction. And it was progressively aggravated until the loss of independent living ability or death due to concurrent infection. The main clinical manifestations are cognitive dysfunction mainly caused by early or recent memory impairment; place orientation and character orientation disorders that often get lost or do not recognize familiar people in the past; mental and behavioral abnormalities such as insomnia, restlessness, and delirium and social barriers, etc. (Wu Simiao, Sichuan Journal of Physiological Sciences, 2009, No. 31). Current studies have shown that the pathological features of AD are mainly atrophy of the large cerebral c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P25/00A61P25/28A61K35/646A61K35/648
CPCA61K35/646A61K35/648A61K36/258A61K36/481A61K36/537A61K36/539A61K36/704A61K36/748A61K36/896A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 高陆白冰孙佳明姜文月徐建石菊王美慧于艳辉
Owner 吉林天力泰药业有限公司
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