Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

46 results about "Phellodendron amurense" patented technology

Phellodendron amurense is a species of tree in the family Rutaceae, commonly called the Amur cork tree. It is a major source of huáng bò (Chinese: 黄柏 or 黄檗), one of the 50 fundamental herbs used in traditional Chinese medicine. The Ainu people used this plant, called shikerebe-ni, as a painkiller.

External traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment

The invention belongs to the technical field of traditional Chinese medicines, and provides an external traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment. The traditional Chinese medicine composition comprises the following components: prepared kusnezoff monkshood root, lycopodium clavatum, garden burnet, rheum officinale, radix clematidis, ligusticum wallichii, rhizoma zingiberis, angelica sinensis, Sinkiang lithospermum, peach kernel, fried gardenia, turmeric, radix angelicae pubescentis, asarum, notopterygium root, sappan wood, red paeony root, garden balsam stem, vinegar frankincense, vinegar corydalis tuber, vinegar myrrh, vinegar rhizoma cyperi, bran-fried fructus aurantii and golden cypress. The invention further discloses a preparation method and application of the traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment. The traditional Chinese medicines perform respective functions in monarch, minister, assistant and guide, the whole formula has the effects of promoting blood circulation to remove blood stasis, activating meridians to stop pain, dispelling wind and eliminating dampness, and reducing swelling and removing stasis, a synergistic treatment effect on tendon injury, blood stasis, swelling and pain and bone impediment is formed through a multi-target-point synergistic effect, the limitation that a traditional Chinese medicine with a single effect is difficult to comprehensively deal with is solved, and the effect of treating both symptoms and root causes is achieved; the traditional Chinese medicine composition has remarkable social benefits and clinical application value.
Owner:TIANJIN INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL (TIANJIN NANKAI HOSPITAL)

Ecological water capable of removing fruit peculiar smell as well as preparation method and application of ecological water

The invention belongs to the technical field of ecological water, mainly relates to ecological water for removing fruit peculiar smell, and particularly relates to ecological water for removing fruit peculiar smell and a preparation method thereof. Neotame and glucose modified cortex phellodendri are matched with tupistra chinensis, pogostemon cablin, liquorice and clove to be decocted into a traditional Chinese medicine decoction. According to the invention, lactobacillus plantarum ATCC 8014 and bacillus subtilis ATCC 6633 are used for fermentation. The antibacterial activity of the ecological water is improved, and the bitter taste of the cortex phellodendri is effectively removed due to the synergism of the two sweetening agents, namely the neotame and the glucose. The bacillus subtilis HZ-72 antagonistic bacteria used in the invention can enhance the capability of inhibiting pathogenic bacteria. Syzygium aromaticum has antibacterial activity, pogostemon cablin has an antiviral effect, and the syzygium aromaticum and the pogostemon cablin cooperate to enhance the antibacterial The ecological water prepared by the invention can remove peculiar smell and preserve freshness, and has a great development prospect in the field of fruit preservation.
Owner:重庆市普康品牌运营管理有限公司

Traditional Chinese medicine composition for treating high-risk HPV infection

The invention belongs to the field of biological medicine, and relates to a traditional Chinese medicine composition for treating high-risk HPV infection. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: radix sophorae flavescentis, rhizoma smilacis glabrae, fructus cnidii, cyrtomium fortunei, dried alum, pericarpium zanthoxyli, cortex phellodendri and raw radix stemonae.
Owner:马堃

Application of berberine or berberine hydrochloride in preparation of medicine for resisting HPV infection related diseases

The invention discloses application of berberine or berberine hydrochloride in preparation of drugs for resisting HPV infection related diseases. Preferably, the berberine is an extract of natural plants such as coptis chinensis, golden cypress, berberis poiretii schneid or Chinese mahonia. According to the application, the new application of the berberine or the hydrochloride thereof in the aspect of resisting the HPV virus is expanded, and the berberine or the hydrochloride thereof is used for preparing the preparation for resisting the HPV infection, so that diseases related to the HPV infection can be prevented or treated, and the virus is promoted to become negative. As a natural plant extract, berberine is high in safety and not easy to generate drug resistance, and has important clinical significance when being used for preparing Chinese patent medicine products for resisting HPV infection.
Owner:GUIYANG XINTIAN PHARMA CO LTD +1

Traditional Chinese medicine extract lotion for treating haemorrhoids and preparation method thereof

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine extract lotion for treating haemorrhoids and a preparation method of the traditional Chinese medicine extract lotion. The traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 16-20 parts of garden burnet, 10-12 parts of sophora flowers, 8-10 parts of golden cypress, 8-10 parts of radix sophorae flavescentis, 6-8 parts of fig leaves, 5-8 parts of angelica sinensis and 5-8 parts of fructus kochiae. The preparation method comprises the following steps: crushing and sieving the raw material medicines, adding water, decocting and extracting, combining filtrate, and carrying out vacuum concentration. Through a scientific formula ratio and a synergistic effect of the traditional Chinese medicines, various symptoms such as bleeding, swelling and pain and itching caused by haemorrhoids can be effectively relieved. Moreover, the vacuum concentration process adopted by the invention can be used for concentrating at a relatively low temperature, so that the damage to heat-sensitive effective components is avoided, the stability of the obtained extracting solution is remarkably improved, the final curative effect of the product is ensured, and the problems of slow effect taking and poor stability of medicines in the prior art are solved.
Owner:SHANXI HONGTAI TECHNOLOGY CO LTD

Maintenance solution for culturing influenza virus as well as preparation method and application of maintenance solution

The invention relates to the technical field of biological medicines, in particular to a maintenance solution for culturing influenza viruses as well as a preparation method and application of the maintenance solution. The maintenance liquid comprises a basic culture medium and effective components, the effective components comprise amino acids, vitamins, salts and a virus nutrition enhancer, and the virus nutrition enhancer is a microorganism induced culture extract. The extract is prepared by inoculating fermentation microbial bacteria, performing induced culture through a plant induction factor extract containing American ginseng, polygonum cuspidatum and golden cypress, and then performing autolysis and enzymolysis in the presence of compound metabolic regulatory factors, namely trichosalix A and N-acetylcysteine. The maintenance fluid can significantly enhance host cell metabolism, inhibit cell antiviral response and delay cell apoptosis after infection, so that the culture yield and process stability of influenza viruses are significantly improved under the condition of no dependence on serum.
Owner:JIANGSU WALVAX BIOTECHNOLOGY CO LTD

Compound cinnabar freeze-dried powder and preparation process thereof

This invention provides a compound Phellodendron amurense freeze-dried powder and its preparation process, relating to the field of deep processing technology of compound Phellodendron amurense extract. The preparation process includes the following steps: 80±10 parts by weight of Forsythia suspensa, 40±5 parts by weight of Phellodendron amurense, 40±5 parts by weight of Lonicera japonica, 40±5 parts by weight of Taraxacum mongolicum, and 2.4±0.3 parts by weight of Scolopendra subspinipes. S1: Take a certain weight of the above five ingredients, add water and decoct, concentrate to a clear extract with a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 70%, let stand, concentrate until there is no alcohol odor, and obtain compound Phellodendron amurense ethanol extract; S2: Take the compound Phellodendron amurense ethanol extract, add water to a certain volume, refrigerate, filter, and obtain compound Phellodendron amurense freeze-dried stock solution; S3: Take the compound Phellodendron amurense freeze-dried stock solution, fill, and freeze-dry to obtain compound Phellodendron amurense freeze-dried powder. The compound Phellodendron amurense freeze-dried powder prepared by this invention solves the problems of existing coatings being non-sterile, unstable, and inconvenient to transport.
Owner:SHANDONG HANFANG PHARMA

Compound traditional Chinese medicine preparation for targeting egg drop syndrome of duck and goose

PendingCN122321083ABiotechnologyDisease
The application relates to the technical field of traditional Chinese medicine preparation, and particularly discloses a compound traditional Chinese medicine preparation for targeting egg duck and goose egg cytoplasmic disease, which comprises the following components: white head, Coptis chinensis, Huangqi, Phellodendron amurense, wine Danpi, bran-fried peach kernel, Chinese perilla, pomegranate peel, liquorice, honeysuckle, Andrographis, figwort, emblic, ginger, fried atractylodes, fried safflower, Xianhecao, spiny amaranth, and Poria cocos. Through the combination of monarch, minister, assistant and messenger, the core effects of heat-clearing and detoxifying, blood-cooling and dysentery-stopping, and dampness-drying and insect-killing of the medicines are synergistically exerted, the pathogenesis characteristics of the egg cytoplasmic disease are accurately targeted, blood stasis and blood circulation are promoted to eliminate the swelling of the lesion, and the intestinal mucosa damage is repaired to stop bleeding, the symptoms of hematochezia, diarrhea and oviduct inflammation of the egg duck and goose caused by the egg cytoplasmic disease are effectively relieved, the problems of the decreased antibiotic effect, drug residue, bacterial flora disorder and food safety risk are effectively solved, and the compound traditional Chinese medicine preparation has the remarkable progress of drug resistance, safety, no residue, intestinal protection and green environmental protection.
Owner:JINMUTANG BIOTECHNOLOGY (TEXAS) CO LTD

A plant composition with antibacterial properties, its preparation method and application

This invention relates to the field of antibacterial product technology, specifically to a plant composition with antibacterial effects, its preparation method, and its application. The plant composition, by weight, comprises the following raw material components: 2-6 parts of Lophatherum gracile, 2-5 parts of Rhodomyrtus tomentosa, 1-5 parts of Phellodendron amurense, and 2-8 parts of Podocarpus macrophyllus. The plant composition of this invention has the advantages of good efficacy and no side effects in inhibiting Staphylococcus aureus, Escherichia coli, Candida albicans, Malassezia furfur, and Propionibacterium acnes.
Owner:珠海远大美业生物科技有限公司 +1

Amur corktree bark extracting solution sampling equipment and use method thereof

The invention discloses phellodendron chinense extracting solution sampling equipment and a use method thereof, and belongs to the technical field of detection sampling equipment.The phellodendron chinense extracting solution sampling equipment comprises an extraction assembly, a first connector, a second connector and a third connector, and the first connector, the second connector and the third connector are installed along the side wall of an extraction kettle in a penetrating mode from top to bottom; the lower end of the second connector is provided with a fourth connector at the same height as the third connector through a second sleeve, a third sleeve is connected between the fourth connector and the third connector, the first sleeve, the second sleeve and the third sleeve are externally connected with a cold source, and metering valves are arranged at the inlet ends of the first connector, the second connector and the fourth connector. The first connector, the second connector and the third connector are arranged from top to bottom along the side wall of the extraction kettle, the flow ratio of 2: 3: 5 is accurately controlled in cooperation with the metering valves, synchronous stratified sampling of upper, middle and lower layers of extracting solutions is achieved, the representativeness and detection accuracy of samples are remarkably improved, and the detection efficiency is improved. The defect that real material distribution in the kettle cannot be reflected by traditional single-point sampling is overcome.
Owner:SICHUAN FORESTRY RES INST (SICHUAN FORESTRY IND RES & DESIGN INST)

Probiotic-containing composition for inhibiting private pathogenic bacteria as well as preparation method and application of probiotic-containing composition

The invention relates to the technical field of daily chemical products, in particular to a probiotic-containing private pathogenic bacterium inhibiting composition and a preparation method and application thereof. The composition is formed by compounding a probiotic composition, a plant extract composition and silver ions or colloidal silver, the probiotic composition comprises the following components: corn starch, mannitol, microcrystalline cellulose, cane sugar, hydroxypropyl methyl cellulose, tocopheryl acetate, melaleuca alternifolia leaf oil and lactobacillus. The plant extract comprises a plant extract 1 and a plant extract 2, and the plant extract 1 comprises the following components: a radix sophorae flavescentis extract, a fructus cnidii extract, a cortex phellodendri extract, an artemisia capillaris extract, a matricaria recutita extract and a snow lotus herb extract; the plant extract 2 comprises the following components: a clove bud extract, litsea cubeba fruit oil, a thyme extract and a radix sophorae flavescentis extract, the growth of vaginal pathogenic bacteria at private parts is inhibited, meanwhile, the influence on beneficial bacteria in the vagina is reduced, the micro-ecological balance of the vagina is maintained, and the effect of preventing vaginal diseases is achieved.
Owner:HAINA SHANGPIN (SHENZHEN) INT TRADE CO LTD

Clostridium butyricum microecological preparation composition for improving sperm quality of livestock and poultry

The invention relates to the field of microorganisms, and particularly discloses a clostridium butyricum microecological preparation composition for improving the sperm quality of livestock and poultry. The preparation method comprises the following steps: selecting materials such as cortex phellodendri to prepare mixed powder, using materials such as zinc-rich edible yeast powder to prepare a pasty bacterial colony proliferation culture medium, using materials such as the mixed powder and clostridium butyricum dry powder to prepare activated clostridium butyricum bacterial sludge, and performing mixed fermentation on the activated clostridium butyricum bacterial sludge and the pasty bacterial colony proliferation culture medium; and finally, pouring a mixed solution formed by xanthan gum, fructo-oligosaccharide and purified water into mixed dry powder of materials such as the bacteria-rich fermentation mixture, L-carnitine and the like to obtain a blend wet material, and drying the blend wet material to obtain the microecological preparation composition. The microecological preparation composition is added into the feed, so that the palatability and the nutrient utilization degree of the feed can be effectively improved, the ingestion and digestion of livestock and poultry are promoted, the organism immunity of the livestock and poultry is enhanced, and the semen quality of the livestock and poultry is improved on the premise of avoiding overdraft of the livestock and poultry.
Owner:SHAANXI AGRICULTURE & FORESTRY VOCATIONAL & TECHNICAL UNIVERSITY

A method for realizing rapid determination of contents of different processed carbonized phellodendri pieces based on near infrared spectroscopy technology

PendingCN122345589AScattering correctionPhellodendrine
This invention proposes a method for rapid determination of the content of Phellodendron amurense charcoal slices processed at different temperatures using near-infrared spectroscopy. Near-infrared spectroscopy is used to collect spectral information of Phellodendron amurense charcoal slices processed at different temperatures. Background interference is eliminated through preprocessing methods such as baseline correction, standard normal variable transformation, multivariate scattering correction, and first derivative. Combined with competitive adaptive reweighted sampling, CARS combined with iterative retention of information variables, and iterative combination optimization, a partial least squares regression quantitative prediction model is established. This model achieves accurate prediction of the content of five key components: 5-O-FQA, 3-O-FQA, berberine, berberine, and berberine, with prediction correlation coefficients all exceeding 0.90. This invention combines spectral information with chemometric methods to establish a digital content prediction model based on near-infrared spectroscopy for online monitoring of the Phellodendron amurense charcoal slice processing process. It has the advantages of objectivity, speed, non-destructive nature, and reliability, effectively solving the technical problem of lack of objectivity in existing technologies based on human judgment.
Owner:NANJING UNIV OF TRADITIONAL CHINESE MEDICINE

Traditional Chinese medicine composition for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae and application of traditional Chinese medicine composition

PendingCN121754625AAntipyreticAnalgesicsSequelaUterine epithelium
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.
Owner:YUNNAN UNIVERSITY OF CHINESE MEDICINE

A plant composition for repairing, soothing, and anti-dandruff and a preparation method thereof

This invention proposes a plant-based composition for repairing, soothing, and removing dandruff, and its preparation method, belonging to the fields of medical, dental, or cosmetic formulations. The composition is a compound of camellia seed extract, centella asiatica extract, dipotassium glycyrrhizate, phellodendron amurense extract, and ginger root extract. This invention targets scalp inflammation caused by sebum oxidation and microbial imbalance. It utilizes the abundant saponins and unsaturated fatty acids in camellia seed extract to gently remove dandruff while replenishing the scalp's lipid barrier; phellodendron amurense extract and dipotassium glycyrrhizate work synergistically to exert anti-inflammatory and anti-allergic effects, relieving itching caused by excessive dandruff; centella asiatica extract promotes fibroblast proliferation and repairs the damaged scalp barrier. This composition can be applied to shampoos or scalp serums. Human trials have shown that the product, while removing dandruff and controlling oil, significantly improves scalp hydration and reduces scalp redness and swelling, achieving scalp care from a symptom-treating to a root-cause-treating approach.
Owner:GUANGZHOU ZHISHICUI TECHNOLOGY CO LTD

Traditional Chinese medicine composition for promoting wound healing and relieving inflammatory response and preparation method thereof

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a traditional Chinese medicine composition for promoting wound healing and relieving trauma local lesion inflammatory response, which is prepared by adopting radix sophorae flavescentis, alum, raw rhubarb, scutellaria baicalensis, golden cypress and mint as raw materials and performing proper weight proportioning; in the formula, radix sophorae flavescentis and alum are used as monarch drugs, rheum officinale, scutellaria baicalensis and golden cypress are used as ministerial drugs, mint is used as adjuvant and conductant drugs, the drug effects are guided to the exterior, and the whole formula has the effects of clearing heat and drying dampness, removing toxicity and diminishing swelling, and activating blood and promoting tissue regeneration, and aims at skin lesions with damp-heat syndromes. Under the combined action of all the medicine components, the traditional Chinese medicine composition has the effects of clearing heat, drying dampness, detoxifying, diminishing swelling, activating blood and promoting tissue regeneration, postoperative incision healing can be effectively promoted, local skin lesion inflammatory response is improved, clinical observation research and animal experiment research prove that the effect is remarkably superior to that of a common western medicine treatment method, and the traditional Chinese medicine composition is worthy of popularization and application. The application range is wide, and the medicine safety is good.
Owner:GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI

Traditional Chinese medicine ointment with tissue repair function and preparation method thereof

The invention belongs to the technical field of pharmaceutical preparations, and discloses a traditional Chinese medicine ointment with a tissue repair function and a preparation method of the traditional Chinese medicine ointment. The traditional Chinese medicine composition is prepared from, by weight, 3-10 parts of rhizoma coptidis, 3-10 parts of radix scutellariae, 3-10 parts of cortex phellodendri, 10-15 parts of radix angelicae sinensis, 5-10 parts of rhizoma bletillae, 5-10 parts of dragon's blood, 1-5 parts of pearl powder, 5-10 parts of radix arnebiae seu lithospermi, 5-10 parts of raw radix sanguisorbae, 1-5 parts of elephant hide, 10-15 parts of radix angelicae, 10-15 parts of radix salviae miltiorrhizae, 5-10 parts of radix paeoniae rubra, 5-10 parts of frankincense and 5-10 parts of myrrh. 5-10 parts by weight of safflower, 5-10 parts by weight of pseudo-ginseng and 10-15 parts by weight of honeysuckle; the composition further comprises lidocaine, an r-bFGF solution, multivitamins and an oily solvent. Vitamin C and vitamin E are added, so that the anti-oxidation effect of the formula can be further enhanced, collagen synthesis is promoted, and the immunity is enhanced. In combination with an r-bFGF solution, tissue repair and cell growth can be more effectively promoted.
Owner:张婧媛

Tablet for treating asthma caused by excessive phlegm and preparation method thereof

The invention relates to the technical field of tracheitis treatment, in particular to a spittoon asthma tablet and a preparation method thereof. The tablets for treating asthma caused by excessive phlegm comprise 60-80 parts of radix sophorae flavescentis extract, 5-10 parts of golden cypress fruit oil, 20-30 parts of filler, 1-2 parts of lubricant, 5-10 parts of lily, 2-5 parts of fried almond and 0.5-1 part of liquorice. The sophora flavescens extract, the cortex phellodendri oil and the lily have a synergistic effect, and after the sophora flavescens extract, the cortex phellodendri oil and the lily are combined, cough and asthma such as chronic tracheitis or bronchitis can be remarkably treated, and the effect is remarkable.
Owner:ZHONG YAN PHARM CO LTD OF JILIN PROVINCE

Traditional Chinese medicine composition for treating erysipelas and preparation method thereof

PendingCN121987698AAntibacterial agentsPlant ingredientsItea virginicaIndigofera kirilowii
The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating erysipelas and a preparation method thereof. The traditional Chinese medicine composition comprises the following components: astragalus membranaceus, artemisia anomala, sappan wood, callicarpa macrophylla, winged euonymus twig, honeysuckle, purslane, lithospermum, sanguisorba officinalis, cacumen biotae and golden cypress. Pharmacodynamic experiments show that the traditional Chinese medicine composition obviously relieves lower limb swelling of erysipelas rats, reduces the content of NO in serum, increases the content of TNF-alpha in the serum, reduces the lesion score of lesion parts, and effectively improves related symptoms of erysipelas. The traditional Chinese medicine composition is wide in raw material source, easy to collect, simple in preparation process, high in safety, free of obvious adverse effects and free of adverse effects on the environment.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE

A method for simultaneously identifying the components of coptis chinensis and phellodendron amurense by thin layer chromatography and its application

The application relates to the technical field of traditional Chinese medicine detection, and particularly discloses a thin-layer chromatography method for simultaneously identifying components of Huanglian and Huangbai and application thereof. The thin-layer chromatography method for simultaneously identifying components of Huanglian and Huangbai provided by the application comprises the following steps: (1) preparing test sample solution, Huanglian control medicinal material solution, Huangbai control medicinal material solution and control sample solution respectively; (2) spotting the above solutions on the same silica gel G thin-layer plate, using n-hexane-n-butanol-methanol-water with a volume ratio of (2.5-3.5):(2.5-3.5):(1.5-2.5):(0.8-1.2) as a developing agent, placing the silica gel G thin-layer plate in a developing jar, developing, taking out, air-drying, and then observing under a light source with a wavelength of 360-370 nm. The thin-layer chromatography method can quickly and simply identify the components of Huanglian and Huangbai in traditional Chinese medicine external preparation, and realizes quality control of the traditional Chinese medicine external preparation.
Owner:SHANTOU MEBO PHARMA CO LTD

Screening identification and application of berberine bridge enzyme and 3 '-hydroxylase PaCYP71BG29 participating in berberine biosynthesis in amur corktree

The invention relates to a key enzyme PaCYP71BG29 for catalyzing (S)-bovine heart alkali to form (S)-golden corydalis alkali and catalyzing (S)-N-methyl combined spiceine to form (S)-3 '-hydroxy-N-methyl combined spiceine in Phellodendron amurense as well as a coding gene and a function of the key enzyme PaCYP71BG29. The key enzyme PaCYP71BG29 is used for catalyzing (S)-bovine heart alkali to form (S)-golden corydalis alkali and catalyzing (S)-N-methyl combined spiceine to form (S)-3'-hydroxy-N-methyl combined spiceine. Belongs to the technical field of gene engineering. The invention discloses an open reading frame sequence of amur corktree PaCYP71BG29 gene and an amino acid sequence coded by the amur corktree PaCYP71BG29 gene. Candidate CYP450s genes are screened on the basis of amur corktree genome, transcriptome and metabolome data, a pET28a-CYP450s prokaryotic expression vector is constructed, and the functions of the amur corktree CYP450s genes are verified in vitro by taking (S)-N-methyl lingenine, (S)-oxadiine and (S)-tetrahydrocotetrandrine as substrates. The results prove that the PaCYP71BG29 has the function of catalyzing the (S)-bovine heart fruit alkali to form the (S)-golden corydalis alkali, the currently reported genes are FAD-dependent BBE genes, the expression efficiency in heterologous hosts such as large intestines and yeast is low, and the synthetic biological research of BIAs is restricted. In addition, the PaCYP71BG29 also has weak activity for catalyzing the formation of the (S)-3 '-hydroxy-N-methyl lingenine from the (S)-N-methyl lingenine. According to the invention, the CYP450 gene participating in the formation of the berberine bridge is reported for the first time, and a foundation is laid for the biosynthesis and synthetic biology research of the protoberberine alkaloids with important medicinal values.
Owner:NORTHEAST FORESTRY UNIV

Preparation method of compound traditional Chinese medicine probiotic fermentation liquor for treating chicken colibacillosis, fermentation liquor and application

The invention relates to the technical field of traditional Chinese medicine fermentation, in particular to a preparation method of compound traditional Chinese medicine probiotic fermentation liquor for treating chicken colibacillosis, the fermentation liquor and application. Wherein the traditional Chinese medicine composition comprises the following raw materials: coptis chinensis, golden cypress, scutellaria baicalensis, isatis root, rheum officinale and liquorice; s2, preparing a strain culture medium; s3, adding the compound extracting solution into a strain culture medium to prepare a fermentation culture medium; s4, inoculating probiotics to the fermentation culture medium for fermentation; a traditional medicinal and edible traditional Chinese medicine compound is fermented by using bacillus subtilis, and the traditional Chinese medicine compound is biologically converted, so that the strain activity and the effectiveness of the medicinal and edible traditional Chinese medicine compound can be remarkably enhanced, and the content of active substances in a traditional Chinese medicine compound extracting solution is increased; meanwhile, the compounds in the compound can provide nutrient substances for the growth of the bacillus subtilis and promote the growth of the bacillus subtilis, so that the effects of the traditional Chinese medicines and the probiotics are exerted to the greatest extent.
Owner:MURICO BIOENGINEERING TECH CO LTD

Method for accelerating germination and improving seedling emergence rate of phoebe sheareri

The application belongs to the technical field of plant seedling, and more particularly relates to a method for rapidly germinating and improving the germination rate of Phellodendron amurense seeds. The method comprises the following steps: disinfecting the Phellodendron amurense seeds with alcohol and sodium hypochlorite solution, and then naturally storing the seeds in sand at low temperature for 87 days. The germination rate and the germination speed of the Phellodendron amurense seeds are significantly improved by optimizing the storage germination conditions and the ratio of the seedling substrate, and the germination rate can reach 73.67 %. The method is simple in operation, low in cost, and environmentally friendly, and is suitable for large-scale seedling and afforestation of Phellodendron amurense.
Owner:JIANGXI AGRICULTURAL UNIVERSITY

Clausena lansium stemming and fermenting integrated device

The utility model discloses a clausena lansium stemming and fermenting integrated device, and relates to the technical field of fruit fermentation, the clausena lansium stemming and fermenting integrated device comprises a fermentation tank, a crushing box and a stemming box, the bottommost part of the fermentation tank is provided with a liquid outlet, the crushing box is communicated with the fermentation tank, and two crushing rollers with parallel axes and relatively rotating are rotatably arranged in the crushing box; a feeding port and a slag discharging port are formed in the stem removing box, the stem removing box is communicated with the crushing box, two stem removing rollers and a screen are rotationally installed in the stem removing box, the axes of the two stem removing rollers are parallel, the two stem removing rollers rotate relatively, the screen is located below the stem removing rollers, and the communicating position of the stem removing box and the crushing box is located on the lower side of the screen. The integrated operation of peduncle removal, crushing and fermentation of the clausena lansium is realized, the occupied area of equipment is reduced in the whole process, the pollution risk in the material transfer process is reduced, and the fermentation quality and the production efficiency are improved.
Owner:SPICE & BEVERAGE RES INST CHINESE ACAD OF TROPICAL AGRI SCI

Hydrogel dressing for promoting healing and preventing scars after fire needle operation and preparation method thereof

The invention belongs to the technical field of fire needle postoperative nursing, and particularly relates to a composite hydrogel dressing which is specially used for treating postoperative wounds through traditional Chinese medicine fire needles and has the functions of promoting healing and preventing scar hyperplasia and a preparation method of the composite hydrogel dressing. According to the composite hydrogel dressing, sodium alginate, sodium carboxymethyl cellulose and polyvinylpyrrolidone K90 serve as main matrixes, a double-network structure is constructed through dynamic covalent cross-linking, a cortex phellodendri extract, rhizoma bletillae polysaccharide and asiaticoside are loaded, and slow release and targeted permeation of drugs are achieved. The hydrogel has good biocompatibility and wet wound environment maintenance capability, can significantly promote epidermal cell migration and granulation tissue formation, and inhibits fibroblast over-proliferation, thereby reducing the risk of scar generation. The preparation process adopts low-temperature homogenization and cross-linking reaction under the protection of nitrogen, so that the stability and batch consistency of the active ingredients are ensured.
Owner:TAIHE HOSPITAL OF SHIYAN CITY (AFFILIATED HOSPITAL OF HUBEI UNIVERSITY OF MEDECINE)

A volatile oil emulsion of phellodendron amurense leaves, and a preparation method and application thereof

The application discloses a volatile oil emulsion of phellodendri chinensis leaves and a preparation method and application thereof, and relates to the field of agricultural and sideline product processing. Specifically, the volatile oil emulsion of phellodendri chinensis leaves comprises the following components: 80-150 parts by weight of volatile oil of phellodendri chinensis leaves, 70-180 parts by volume of an emulsifier, and 1200-2000 parts by volume of water; wherein the volatile oil of phellodendri chinensis leaves is obtained by water vapor distillation. The volatile oil emulsion of phellodendri chinensis leaves has high stability, good palatability, and obvious inhibitory effect on staphylococcus aureus. In addition, the volatile oil emulsion of phellodendri chinensis leaves can effectively alleviate pneumonia of mice infected by staphylococcus aureus, inhibit the activation of NLRP3 inflammasome and the production of inflammatory factors; therefore, the volatile oil emulsion of phellodendri chinensis leaves has an auxiliary treatment effect on bacterial pneumonia and has a good application prospect.
Owner:FOSHAN UNIVERSITY

Ice-borne aesculus and phellodendron burn medicine and its grading and applying process

PendingCN122351351AAesculusSesame Oils
This invention belongs to the technical field of burn medicine containing Sanguisorba officinalis and Phellodendron amurense, and particularly relates to a burn medicine containing borneol and its graded preparation and application process. The raw materials of the burn medicine are as follows by weight: 20-30 parts of Sanguisorba officinalis, 20-30 parts of Phellodendron amurense, 10-15 parts of Coptis chinensis, 10-15 parts of Akebia trifoliata, 10-15 parts of Glycyrrhiza uralensis, and 1-5 parts of borneol. The graded preparation and application process includes: using processed or raw Sanguisorba officinalis and Phellodendron amurense; mixing and pulverizing all raw materials, and passing them through a 100-200 mesh sieve to obtain fine powder; for minor burns, the powder is mixed with sesame oil for application, and for severe burns, the powder is mixed with egg white for application, and should be prepared and used immediately.
Owner:左立华

Traditional Chinese medicine composition for improving semen quality of stud rams and application of traditional Chinese medicine composition

The invention relates to the technical field of livestock breeding, and particularly discloses a traditional Chinese medicine composition for improving semen quality of stud rams and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from raspberry, salted semen cuscutae, herba epimedii, wine-processed cistanche deserticola, fructus amomi, golden cypress, cinnamon and honey-fried licorice root according to a specific proportion. According to the traditional Chinese medicine composition provided by the invention, through continuous feeding, the ejaculation amount and sperm motility of the breeding rams can be remarkably improved, the semen quality and sexual desire performance are improved, and the service life of the breeding rams is prolonged; natural medicinal materials are adopted, endocrine disorder or drug resistance is not prone to being caused, and the composition is suitable for being popularized and used in large-scale farms and meets the requirements for green breeding and sustainable development.
Owner:INNER MONGOLIA AUTONOMOUS REGION ACAD OF AGRI & ANIMAL HUSBANDRY SCI

Plant fermentation bacteriostatic composition as well as preparation method and application thereof

PendingCN121846188AHigh antibacterial activityImprove the stability of antibacterial activityAntibacterial agentsAntisepticsBiotechnologyAngelica Sinensis Root
The invention belongs to the technical field of cleaning hygienic products, and particularly relates to a plant fermentation bacteriostatic composition and a preparation method and application thereof. The plant fermentation bacteriostatic composition comprises a solvent, an antioxidant and a plant fermentation extract, the plant fermentation extract comprises rhizoma atractylodis rhizome fermentation extract, safflower flower fermentation extract, amur corktree bark fermentation extract, angelica root fermentation extract, radix sophorae flavescentis fermentation extract and kochia scoparia fruit fermentation extract. The preparation method comprises the following steps: mixing and crushing rhizoma atractylodis, safflower, amur corktree, angelica sinensis, radix sophorae flavescentis and kochia scoparia raw materials, adding a proper amount of carbon source and nitrogen source, uniformly mixing, then adding a compound bacteria solution containing eurotium cristatum, aspergillus and saccharomycetes, mixing and fermenting, and extracting the fermented materials by adopting a specific mixed solvent to obtain the plant fermentation antibacterial composition. By adopting a specific fermentation process and an extraction solvent, the bacteriostatic activity and the activity stability of the extracted composition can be remarkably improved.
Owner:广州市铭骐生物科技有限公司

Traditional Chinese medicine composition for treating atopic dermatitis, medicinal preparation and preparation method thereof

The invention provides a traditional Chinese medicine composition for treating atopic dermatitis, a pharmaceutical preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises philippine violet herb, divaricate saposhnikovia root, belvedere fruit, eucalyptus leaf, dandelion, wild chrysanthemum flower, mirabilite, amur corktree bark and pulvis fellis suis. The traditional Chinese medicine composition and the pharmaceutical preparation provided by the invention not only can clear away heat toxins of skin, dispel wind pathogens, eliminate dampness and relieve itching, but also take mild skin care into account, adapt to pathogenesis of atopic dermatitis and external administration requirements, take effect directly, are controllable in safety, and have a good treatment effect on atopic dermatitis.
Owner:BEIJING ORIENTAL YUNJIA TECH DEV CO LTD