Application of glaucocalyxin L in pharmacy

A blue calyx and drug technology, applied in the field of medicine, can solve the problems such as no anti-cancer activity of blue calyx L, and achieve the effects of good medicinal prospects, strong pharmacological effects, and strong growth-inhibiting effects.

Inactive Publication Date: 2014-05-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, there is no report about the anticancer activity of calyxin L

Method used

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  • Application of glaucocalyxin L in pharmacy
  • Application of glaucocalyxin L in pharmacy
  • Application of glaucocalyxin L in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] In Vitro Anti-tumor Activity Test of Clyculin L

[0024] 1. Experimental drug:

[0025] Samples: Elysine L, Oridonin A

[0026] Control drug: doxycycline (DOX), Shijiazhuang Ruitian Biochemical Co., Ltd.

[0027] 2. Cell line: provided by the Pharmacology Laboratory of Shanghai Institute of Pharmaceutical Industry

[0028] ①A549 (human lung adenocarcinoma cells); ②HCT116 (human intestinal cancer cells); ③CCRF-CEM (human acute lymphoblastic leukemia cells); ④HL-60 (human acute promyelocytic leukemia).

[0029] The above cell lines were cryopreserved and passaged by the Pharmacology Laboratory of Shanghai Pharmaceutical Industry Research Institute.

[0030] 3. Culture medium: RPMI1640+15%NBS+double antibody

[0031] 4 other materials

[0032] Fully automatic microplate reader: Model: (WellscanMK-2) Manufacturer: Labsystems

[0033] Imported 96-well culture plate, etc.

[0034] 5. Experimental method

[0035] The MTT method is routinely used, and the concen...

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PUM

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Abstract

The invention relates to an application of glaucocalyxin L, in particular relates to an application of glaucocalyxin L in preparing medicaments for treating lung cancer, intestinal cancer or leukemia,wherein the lung cancer is lung adenocarcinoma, the intestinal cancer is colon cancer, and the leukemia is acute lymphocytic leukemia and acute promyelocytic leukemia. The application of the glaucocalyxin L has the advantages that a novel medical application of the glaucocalyxin L is explored, and a new application field is opened; 2, the glaucocalyxin L has a strong pharmacologic action, and indicates a good pharmacologic prospect; 3, massive cell experiment studies prove that the medicament glaucocalyxin L has a strong growth inhibiting effect on a tumor cell line, and the activity of the glaucocalyxin L is superior to that of a known similar compound oridonin. Therefore, the glaucocalyxin L can be used for preparing medicaments for resisting lung cancer, intestinal cancer and leukemia.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular, relates to the application of cyanocalin in pharmacy. Background technique [0002] Cerulein L (Glaucocalyxin L) is the present inventor's from Lamiaceae Camellia plant Glaucocalyxin (Glaucocalyxin (Glaucocalyxin L) Rabdosia japonica (Burm. f .) Hara var. glaucocalyx (Maxim. ) Hara) is a new compound isolated from the whole plant. cyanine L (Glaucocalyxin L) has the following chemical structure: [0003] [0004] Cerulein L ( Glaucocalyxin L) The chemical structure parameters of: [0005] White powder, m.p.235~237℃, ESI-MS m / z: 399[M+Na]+, 377[M+H]+; molecular formula is C 22 h 32 o 5 . HRESI-MS m / z : 377.2317 [M+H] + , 1 H-NMR (600MHz, CDCl 3 )and 13 C-NMR (150MHz, CDCl 3 ) see Table 1. [0006] Table 1 Cerulein L 1 H-NMR and 13 C-NMR data (CDCl 3 , δ) [0007] [0008] [0009] So far, there is no report about the anti-cancer activity...

Claims

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Application Information

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IPC IPC(8): A61K31/22A61P35/00A61P35/02
Inventor陈海生金永生刘洪川
OwnerSECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY