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Method for preparing valid target in gavel fruit vine fruit and application of the same

A technology of effective parts and mallet vine, applied to medical preparations containing active ingredients, pharmaceutical formulas, capsule delivery, etc., can solve the problems of extraction of medicinal parts, pharmacology and mechanism of action research reports, etc., and achieve curative effect Significant, reasonable method design, low cost effect

Inactive Publication Date: 2011-03-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no research reports on the extraction, pharmacology and mechanism of action of medicinal parts

Method used

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  • Method for preparing valid target in gavel fruit vine fruit and application of the same
  • Method for preparing valid target in gavel fruit vine fruit and application of the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 The preparation of the effective part of the mallet fruit vine

[0018] Take about 200g of the vine fruit and crush it, add 1600ml of ethanol, reflux for extraction for 2 hours, filter the filter residue and add 1000ml of ethanol to reflux for 1 hour, combine the two filtrates, recover the ethanol under reduced pressure, and obtain the extract. Suspend this extract with 200ml of water, extract it with petroleum ether three times to degrease, then extract it with n-butanol three times until the extraction layer is nearly colorless, combine the n-butanol extracts, concentrate to obtain 3.08g of medicinal parts .

Embodiment 2

[0019] Embodiment 2 The preparation of the effective part of the mallet fruit vine

[0020] Take about 200g of vine fruit and crush them, add 50% ethanol to percolate and extract for a week, after the percolates are combined, the ethanol is recovered completely under reduced pressure, and the remaining water phase is extracted three times with n-hexane to degrease, and then coated with AB-8 macroporous resin to After elution with water for 3 column volumes, elute with 70% ethanol until the effluent is nearly colorless, collect this part of the eluate, concentrate under reduced pressure to recover ethanol and then spray dry to obtain 2.92 g of medicinal parts.

Embodiment 3

[0021] Embodiment 3 Preparation of the effective part of Hammer fruit vine

[0022] Take about 200g of vine fruit and crush it, add 1600ml of methanol, reflux for extraction for 2 hours, filter the filter residue and add 1000ml of methanol to reflux for 1 hour, combine the two filtrates, recover the methanol under reduced pressure, and obtain the extract. Suspend the extract with 200ml of water, extract it with cyclohexane three times to degrease, then extract it with n-butanol three times until the extraction layer is nearly colorless, combine the n-butanol extracts, concentrate to obtain 3.06g of medicinal extract parts.

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Abstract

The invention relates to a preparation method of the effective parts of the fruit of the plant Capparis Spinosa, comprising the steps as follows: grinding the Capparis Spinosa fruit; extracting and decompressing with methanol or ethanol to get a crude extract; suspending the crude extract; degreasing with small molecular alkyl, then getting effective extract by extracting with butanol or eluting aqueous phase with water-alcohol system using macroporous resin column. The invention extracted from the effective part of Capparis Spinosa fruit is characterized in restraining proliferation of the fiber cell of the systemic sclerosis patients, expression of type I collagen and mRNA of the connective tissue growth factor, synthesis of protein, having no effect on proliferation of the fiber cell of the normal people, synthesis of collagen and expression of CTGF, being used in preparation of medicine for curing progressive systemic sclerosis, and facilitating a plurality of preparation comprising external use preparation and oral preparation. The preparation method has the advantages of reasonable design, simple technique process and low cost and energy consumption.

Description

technical field [0001] The invention relates to the technical field of plant medicine, in particular to a preparation method of the effective part (extract) of the fruit of the vine vine and its application in the preparation of medicines for treating systemic sclerosis. Background technique [0002] The use of Uygur Chinese herbal medicine has a long history. The Xinjiang Uygur Autonomous Region, located in the northwest of my country, is rich in plant species and various in variety. More and more wild species have been widely developed and utilized as traditional Chinese medicine. Capparis spinosa L. The caper species of the cauliflower family, also known as capers, is a semi-shrub-like creeping vine with an inverted conical shape and multi-branched stems, 1-3cm long and about 5mm in diameter; the leaves are nearly leathery. 1-5cm long, 1-3.5cm wide, nearly round or slightly concave at the top, with sharp hard spines, stipules degenerate into spines; flowers and leaves are ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61K9/20A61K9/48A61P43/00A61K131/00
Inventor 曹越兰周长新莫建霞甘礼社郑敏
Owner ZHEJIANG UNIV
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