Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof

A cardiovascular and cerebrovascular disease and composition technology, which is applied to cardiovascular system diseases, drug combinations, testing drug preparations, etc. The effect of large fluctuation of curative effect and strong pharmacological effect

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chuanxiong Xinxiang Xingsan, warms the blood vessels, ascends the head, descends into the sea of ​​blood, has the functions of promoting blood circulation and qi, dispelling wind and relieving pain, and is known as the Qi medicine in the blood by the predecessors. Modern research shows that: total lactones of Chuanxiong, total Alkaloids and chuanxiong volatile oil are its main physiologically active components, which have the functions of relievin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0058] Example 1 of the present invention: Dipyridamole 10g Ligusticum chuanxiong total lactones 100g

[0059] Take dipyridamole, add water for injection, add citric acid and stir to dissolve it, the medicinal solution is ready; take the total lactones of Ligusticum chuanxiong and stir water for injection to dissolve, filter, and the filtrate is ready for use; combine the above two medicinal solutions and boil Add 1.0% (W / V) activated carbon, keep slightly boiling for 30 minutes, filter slightly, adjust the pH of the filtrate to 5.5-7.0, boil, refrigerate (4℃) overnight, coarse filter, fine filter; add mannitol to injection Prepare a 100mg / ml solution with water (the volume ratio of mannitol solution to drug solution is 2:1), mix it with the above filtrate, filter, add water for injection to the specified amount, subpackage, freeze-dry, pre-freeze temperature -45 ℃, pre-freezing time 10h; start vacuuming, and heat to -40℃, keep for 8h; and gradually increase the temperature to 10℃...

Example Embodiment

[0060] Example 2 of the present invention: Dipyridamole 1g Ligusticum chuanxiong total alkaloids 10g

[0061] Take dipyridamole, add water for injection, add tartaric acid and stir to dissolve, the medicinal solution is ready; take the total alkaloid of Ligusticum chuanxiong and stir the water for injection to dissolve, filter, and the filtrate for use; combine the above two medicinal solutions to adjust the pH value 5.5~7.0, add 1.0% activated activated carbon for needles, boil for adsorption, remove charcoal, finely filter, add water for injection to the filtrate to the specified amount, refrigerate overnight at 4°C, coarsely filter, finely filter, and dispense into ampoules, Sterilize and subpackage to obtain 10 parts of Ligusticum chuanxiong total alkaloids and 1 part of dipyridamole small-volume injection or concentrated solution for injection.

Example Embodiment

[0062] Example 3: Dipyridamole 1g Ligusticum chuanxiong total alkaloids 50g

[0063] Take dipyridamole plus water for injection, add tartaric acid and stir to dissolve it, the medicinal solution is ready; take the total alkaloids of Ligusticum chuanxiong and add an appropriate amount of water for injection to dissolve the medicinal solution; combine the above two medicinal solutions and add the specified amount of glucose or chlorinated Sodium, mix and dissolve, add 1.0% activated carbon for needles by volume, boil, keep slightly boiling for 30 minutes, filter slightly, add water for injection to the filtrate to an appropriate amount, adjust the pH to 5.5-7.0, boil, refrigerate overnight at 4°C, coarse Filter, finely filter, add water for injection to the full amount, subpackage, and sterilize to obtain an intravenous infusion of glucose or sodium chloride containing 1 part of dipyridamole and 50 parts of Ligusticum chuanxiong total alkaloids.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its preparing process and quality control method, wherein Dipyridamole and one or two of ligustilide and Ligusticum wallichii alkaloids are employed in combination to obtain various dose forms of injections and oral administration preparations. The composite preparation is mainly used for treating coronary disease, angina pectoris, cerebrovascular disease, pulmonary heart disease, and hypertension.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of medicines. technical background [0002] Among the causes of human death, about 17 million people die from cardiovascular and cerebrovascular diseases in the world every year, accounting for more than 50% of the total death toll, ranking first; among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87% , ranking first; in human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. This grim fact has been highly concerned by all walks of life. There are already a lot of western medicines. Chemical medicines are used to control symptoms and have definite curative effects. , but the bioavailability is low, the curative effect is longer, and the c...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61K31/519A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K9/70A61P9/10A61P9/12A61P3/06A61P11/00G01N30/02G01N33/15
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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