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Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof

A cardiovascular and cerebrovascular disease and composition technology, which is applied to cardiovascular system diseases, drug combinations, testing drug preparations, etc. The effect of large fluctuation of curative effect and strong pharmacological effect

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chuanxiong Xinxiang Xingsan, warms the blood vessels, ascends the head, descends into the sea of ​​blood, has the functions of promoting blood circulation and qi, dispelling wind and relieving pain, and is known as the Qi medicine in the blood by the predecessors. Modern research shows that: total lactones of Chuanxiong, total Alkaloids and chuanxiong volatile oil are its main physiologically active components, which have the functions of relieving spasm, reducing vascular resistance and strongly inhibiting platelet aggregation. Myocardial oxygen supply, reducing myocardial oxygen consumption, etc., but at present, medicinal materials are mostly used as medicine, resulting in low bioavailability and large fluctuations in curative effect; Blood oxygen saturation can improve the blood supply and oxygen supply of the myocardium; however, due to the side effects, it is not suitable for long-term use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1 of the present invention: dipyridamole 10g chuanxiong total lactones 100g

[0059] Take dipyridamole, add water for injection, add citric acid and stir to dissolve it, and use the liquid for later use; take total lactones of Ligusticum chuanxiong and add water for injection, stir to dissolve, filter, and use the filtrate for later use; combine the above two liquid medicines, and boil Add 1.0% (W / V) activated carbon, keep boiling slightly for 30 minutes, filter slightly cold, adjust the pH value of the filtrate to 5.5-7.0, boil, refrigerate (4°C) overnight, coarse filter and fine filter; add mannitol for injection Prepare a 100mg / ml solution with water (the volume ratio of mannitol solution and medicinal solution is 2:1), mix with the above filtrate, filter, add water for injection to the specified amount, subpackage, freeze-dry, and pre-freeze at -45°C ℃, pre-freezing time 10h; start vacuuming, and raise the temperature to -40°C, keep for 8h; and gradually ...

Embodiment 2

[0060] Embodiment 2 of the present invention: dipyridamole 1g chuanxiong total alkaloids 10g

[0061] Take dipyridamole, add water for injection, add tartaric acid and stir to dissolve it, and prepare the liquid for later use; take the total alkaloids of Ligusticum chuanxiong and add water for injection, stir to dissolve, filter, and set aside the filtrate; combine the above two medicinal liquids, and adjust the pH value to 5.5~7.0, add 1.0% activated carbon for needles, boil for adsorption, remove carbon, fine filter, add water for injection to the specified amount of filtrate, refrigerate at 4°C overnight, coarse filter, fine filter, and pack into ampoules, Sterilize and subpackage to obtain 10 parts of total alkaloids of Ligusticum chuanxiong and 1 part of dipyridamole small-volume injection or concentrated solution for injection.

Embodiment 3

[0062] Embodiment 3 of the present invention: dipyridamole 1g chuanxiong total alkaloids 50g

[0063] Take dipyridamole, add water for injection, add tartaric acid and stir to dissolve it, and prepare the liquid for later use; take the total alkaloids of Chuanxiong Rhizoma and add appropriate amount of water for injection to dissolve, and make the liquid for later use; combine the two liquids above, and add a prescribed amount of glucose or chloride Sodium, after mixing and dissolving, add 1.0% activated carbon for needles according to the volume, boil, keep boiling slightly for 30 minutes, filter slightly cold, add water for injection to the filtrate to an appropriate amount, adjust the pH value to 5.5-7.0, boil, refrigerate overnight at 4 °C, crude Filtration, fine filtration, add water for injection to the full amount, subpackage, and sterilize to obtain glucose or sodium chloride intravenous infusion containing 1 part of dipyridamole and 50 parts of total alkaloids of Chuan...

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its preparing process and quality control method, wherein Dipyridamole and one or two of ligustilide and Ligusticum wallichii alkaloids are employed in combination to obtain various dose forms of injections and oral administration preparations. The composite preparation is mainly used for treating coronary disease, angina pectoris, cerebrovascular disease, pulmonary heart disease, and hypertension.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of medicines. technical background [0002] Among the causes of human death, about 17 million people die from cardiovascular and cerebrovascular diseases in the world every year, accounting for more than 50% of the total death toll, ranking first; among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87% , ranking first; in human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. This grim fact has been highly concerned by all walks of life. There are already a lot of western medicines. Chemical medicines are used to control symptoms and have definite curative effects. , but the bioavailability is low, the curative effect is longer, and the c...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61K31/519A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K9/70A61P9/10A61P9/12A61P3/06A61P11/00G01N30/02G01N33/15
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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