A kind of preparation method of anti-methamphetamine egg yolk antibody

A methamphetamine and egg yolk antibody technology, applied in chemical instruments and methods, derived from egg immunoglobulins, peptides, etc., can solve problems such as lack of methamphetamine-specific therapeutic drugs, and reduce addiction and relapse behaviors , high safety, the effect of reducing toxicity

Active Publication Date: 2016-11-30
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem of lack of specific therapeutic drugs against methamphetamine in the prior art, the embodiment of the present invention provides a preparation method of egg yolk antibody against methamphetamine

Method used

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  • A kind of preparation method of anti-methamphetamine egg yolk antibody
  • A kind of preparation method of anti-methamphetamine egg yolk antibody
  • A kind of preparation method of anti-methamphetamine egg yolk antibody

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] 1. Preparation of Methamphetamine-Bovine Serum Albumin Antigen

[0032] 1 Synthesis and identification of haptens

[0033] The hapten can combine with the corresponding antibody to form an antigen-antibody, and the hapten alone cannot stimulate the human or animal body to produce antibodies.

[0034] 1.1 Synthesis

[0035] Weigh 150 mg of methamphetamine hydrochloride and dissolve it in 150 mg of distilled water, add dropwise a NaOH solution with a concentration of 1 mol / L until free methamphetamine is precipitated, and extract with trichloromethane (analytical pure). Use Na 2 SO 4 The precipitated methamphetamine is dried, the precipitated methamphetamine is filtered, and the solvent is evaporated to obtain methamphetamine. Dissolve 120mg of methamphetamine in 120ml of absolute ethanol (spectrally pure), then add 100ml of 1mol / L N-(4-bromobutyl) phthalimide-anhydrous ethanol solution, and add 1- 5ml of triethylamine helps dissolve methamphetamine. Heat to reflux. After the re...

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Abstract

The invention discloses a method for preparing an anti-methamphetamine yolk antibody, belonging to the field of drugs for detoxification. The preparation method of the yolk antibody against methamphetamine comprises: immunizing laying hens with methamphetamine-bovine serum albumin antigen, collecting eggs laid by the laying hens after immunization, extracting and purifying the The egg yolk antibody in eggs, the obtained egg yolk antibody is anti-methamphetamine egg yolk antibody. The anti-methamphetamine egg yolk antibody, the specific anti-methamphetamine egg yolk antibody can first neutralize the free methamphetamine in the patient's blood, thereby reducing the amount of methamphetamine entering the patient's central nervous system, and further reducing the amount of methamphetamine. The toxicity of amphetamine to neurons in the brain. At the same time, the anti-methamphetamine egg yolk antibody can be used as a drug molecule receptor blocker, which can prevent the positive reinforcement of drugs to a certain extent, thereby diluting the patient's psychological desire and reducing Patient's likelihood of relapse.

Description

Technical field [0001] The invention relates to the field of drug detoxification drugs, in particular to a method for preparing an anti-methamphetamine egg yolk antibody. Background technique [0002] Methamphetamine is a central stimulant and has toxic effects on animal and human brain neurons. Its half-life is as long as 10-30 hours. Its toxic effects are mainly manifested in central and sympathetic nervous system stimulation such as high fever, elevated blood pressure, and arrhythmia. Symptoms, confusion, delirium and other serious mental symptoms, severe poisoning can lead to death, long-term use, short-term repeated use or one-time large-dose methamphetamine can lead to addiction. [0003] For the prevention and treatment of methamphetamine overdose and relapse, researchers have been actively exploring in recent years, but most of the prevention and treatment are limited to methamphetamine has exerted toxicological effects on the central nervous system, for example, the dopami...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K16/44C07K16/02
Inventor 陈琳李超英乐凯茹琴马宝苗田香熊琪
Owner JIANGHAN UNIVERSITY
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