Application of ocimene to preparation of antidepressant
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An ocimene and anti-depressant technology, which is applied in the field of medicine, can solve the problems of many side effects, poor drug tolerance, and easy relapse, and achieve the effect of increasing sugar water preference, shortening immobility time, and significantly resisting experimental depression in mice
Inactive Publication Date: 2014-08-13
CHINA PHARM UNIV
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However, most of these traditional antidepressants may take effect only 2 to 4 weeks after medication, and they only work for about 70% of patients. At the same time, there are many side effects, poor patient tolerance to drugs, and easy relapse.
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Embodiment 1
[0013] Influence test of ocimene described in embodiment 1 invention on chronic unpredictable mild stimulation depression model mice
[0014] 1 Experimental method
[0015] 1.1 Establishment of chronic unpredictable mild stimulus depression model
[0016] Establish a chronic mild unpredictable stress model. Among them, the chronic mild stimulation includes: (1) tail suspension for 10 minutes, (2) shaking the mouse cage for 10 minutes, (3) noise (unFM radio) for 3 hours, (4) cage tilt (about 30°) for 8 hours or overnight, (5) wet bedding (150ml water) for 8 hours or overnight, (6) foreign matter for 8 hours or overnight, (7) lighting overnight, (8) tail clamping for 5 minutes, (9) restraint for 10 minutes, ( 10) fasting for 8 hours or overnight, (11) fasting for 8 hours or overnight.
[0017] The model group, the fluoxetine group, and the ocimene high-dose and low-dose groups were given the above-mentioned chronic mild stress for 3 weeks. The above two different stresses we...
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Abstract
The invention relates to the field of medicine, and in particular relates to an application of ocimene to preparation of an antidepressant. As proved by the results of a mouse chronic unpredictable mild stimulation depression model weight appearance experiment, sucrose preference test, open field test, forced swimming test and the like, the ocimene has remarkable anti-depression activity, and can be applied to preparation of antidepressants.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the application of ocimene in the preparation of antidepressant drugs. Background technique [0002] Ocimene (Ocimene) is a colorless or light yellow oily liquid, with grassy, floral and neroli smell. Insoluble in water, soluble in ethanol, ether, chloroform. CAS number: 13877-91-3, the structural formula is as follows: [0003] [0004] Ocimene mainly exists in basil, lavender, tarragon, etc. Basil is a perilla plant, which has the functions of dispelling wind and promoting qi, dispelling dampness and eliminating food, promoting blood circulation and detoxifying. It is used for the treatment of exogenous headache, bloating, gas stagnation, abdominal pain, diarrhea, irregular menstruation, bruises, skin eczema and other diseases. Lavender is a plant of Labiatae, which has the effects of refreshing the mind, enhancing memory, calming and hypnotizing, promoting blood circulation, a...
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