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Compound cold medicinal composition containing bilastine

A composition and drug technology, applied in the field of medicine, to achieve the effects of fast absorption, long half-life in vivo, and good pharmacokinetic properties

Inactive Publication Date: 2014-08-27
HEFEI IND PHARMA INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More preferably 20:30:200

Method used

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  • Compound cold medicinal composition containing bilastine
  • Compound cold medicinal composition containing bilastine
  • Compound cold medicinal composition containing bilastine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Bilastine + pseudoephedrine sulfate + acetaminophen granules (according to 1000 bags)

[0037] components

Dosage

Bilastine

5.0g

pseudoephedrine sulfate

30.0g

Acetaminophen

200.0g

lactose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1.0g

essence

4.0g

[0038] Preparation:

[0039] Feed according to 1000 bags, pass bilastine, pseudoephedrine sulfate, acetaminophen, lactose, and aspartame through 80-mesh sieve, mix well, dissolve carmine in water, make soft material, 20-mesh sieve granules, dried, sieved through a 18-mesh sieve, added essence and magnesium stearate, mixed evenly, and then divided into bags.

Embodiment 2

[0041] Bilastine+pseudoephedrine sulfate+acetaminophen tablets (according to 1000 tablets)

[0042] components

Dosage

Bilastine

10.0g

pseudoephedrine sulfate

30.0g

Acetaminophen

200.0g

microcrystalline cellulose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1.0g

essence

4.0g

[0043] Preparation:

[0044] Pass bilastine, pseudoephedrine sulfate, acetaminophen, microcrystalline cellulose, and aspartame through 80-mesh sieve respectively, mix well, dissolve carmine in water, make soft material, granulate with 20-mesh sieve, and dry , 18-mesh sieve, add essence and magnesium stearate, mix well, and press into tablets.

Embodiment 3

[0046] Bilastine + pseudoephedrine sulfate + acetaminophen solution (according to 1000 bottles)

[0047] components

Dosage

Bilastine

20.0g

pseudoephedrine sulfate

30.0g

Acetaminophen

200.0g

sodium benzoate

3.0g

aspartame

20.0g

sodium bisulfite

2.0g

essence

4.0g

water

10000ml

[0048] Preparation:

[0049] Dissolve bilastine, pseudoephedrine sulfate, and paracetamol in an appropriate amount of water, heat and stir to dissolve, add sodium benzoate, aspartame, sodium bisulfite and essence, filter and add water to the prescribed amount, stir well and distribute That's it.

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PUM

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Abstract

The invention relates to the field of medicine, and in particular relates to a compound cold medicinal composition containing bilastine. The compound medicinal composition contains three types of effective components, namely, bilastine, pseudoephedrine sulfate and acetaminophen. As proved by pharmacodynamic test, the compound medicinal composition has a synergistic effect when treating cold, and can be used for treating cold in clinic.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound pharmaceutical composition containing bilastine, pseudoephedrine sulfate and acetaminophen and a preparation method thereof. Background technique [0002] Flu is a common frequently-occurring disease that can take place throughout the year and is mostly caused by respiratory tract infection. Symptoms such as nasal congestion, nasal mucus, sore throat, dull taste, poor breathing, hoarseness, and cough caused by colds have a strong impact on people's work and life. Clinically, at present, symptomatic treatment is mainly used to relieve various discomfort symptoms caused by colds to patients. [0003] Bilastine is a new type of long-acting histamine antagonist, which can selectively antagonize peripheral H1 receptors and has no obvious affinity for muscarinic receptors. vascular adverse reactions, and has good pharmacokinetic properties (that is, rapid absorption, high bioavaila...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P29/00A61P37/08A61K31/137A61K31/167
Inventor 刘为中何广卫陈娟
Owner HEFEI IND PHARMA INST CO LTD
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