A compound pharmaceutical composition for treating type II diabetes or metabolic syndrome
A technology of composition and medicine, applied in the field of medicine, can solve the problems of not being able to improve IR research reports, etc.
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Embodiment 1
[0037] In Vitro Cell Culture Studies of Hepatocytes
[0038] "Hepatocyte 5-HT synthesis system, 5-HT 2A,2B Receptor gene expression, GLUT gene expression, changes upon DEX or OA stimulation; and inhibition of 5-HT synthesis or blockade of 5-HT 2A,2B receptor (5-HT 2A,2B R) on the improvement of IR caused by DEX or OA" research results.
[0039] 1.1 Experimental method
[0040] (1) Cell culture
[0041] The rat BRL-3A liver cell line was cultured in vitro, and the experiment was completed at the 10-20 generation of cell passage. Cells were cultured at 37°C with 5% CO 2 cultured in PRMI-1640 medium containing 10% fetal bovine serum, and combined with penicillin / lianmycin for antibacterial. Cell seeding concentration 5×10 5 One per bottle, after 24 hours of culture, the drug can be administered when the cell proliferation reaches 70-80% of the bottom area of the bottle. IR cell models were stimulated with dexamethasone (DEX) or oleic acid (OA) respectively. DEX-stimula...
Embodiment 2
[0075] Animal Experimental Research - Rat IR and Diabetes Model Induced by DEX
[0076] Compare the therapeutic effect of SAR combined with pCPA, CDP, BSA, and each alone on DEX-induced IR and diabetes models in rats, so as to verify the synergistic effect of SAR combined with pCPA, CDP, BSA on the treatment of IR and diabetes .
[0077] 2.1 Experimental method
[0078] (1) Animal handling
[0079] 108 male Wistar rats were randomly divided into 18 groups (6 in each group): control group, IR model group, IR model SAR treatment group, IR model SAR+pCPA compound treatment group (SAR: pCPA in different weight ratios of 4 compound), the IR model pCPA treatment group, the IR model SAR+CDP compound treatment group (SAR:CDP is 4 kinds of compound according to different weight ratios), the IR model CDP treatment group, the IR model SAR+BSA compound treatment group (SAR: 4 compound formulations of BSA according to different weight ratios), IR model BSA treatment group. Animals were...
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