Application of compound medicine composition in preparation of medicine for treating interstitial pneumonia
A composition and interstitial technology, applied in the field of compounds, to achieve significant curative effect advantages and obvious synergistic effects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0035] Changes in the expression of 5-HT synthase, 5-HT2A receptor and MAO-A in lung tissue during BLM-induced IP in mice
[0036] 1.1 Experimental method
[0037] Male C57BL / 6 mice (clean grade), weighing 20-24 g, were used in the experiment. The animals were housed in ordinary rat cages, maintained at room temperature of 24 ± 2 °C, light control ensured 12 hours of light and dark conditions, and fed with ordinary water. After the animals were anesthetized, bleomycin (BLM, 3.5 mg / kg) was administered intratracheally by puncture to establish an animal model of interstitial pneumonia (IP), and the control group was given an equal volume of normal saline. After 21 days of modeling, the animals were sacrificed, and the lung tissue was taken for formalin fixation, tissue sectioning, and immunohistochemical staining to detect the 5-HT 2A receptor (5-HT 2A receptor) in the lung tissue. 2A R), protein expression of 5-HT synthase Tph1 and AADC, 5-HT degrading enzyme monoamine oxidase...
Embodiment 2
[0041] Therapeutic effects of drugs on IP in BLM-induced mice
[0042] Comparing the therapeutic effects of sarpogrelate hydrochloride (SH) and carbidopa (CDP) in combination and each alone on BLM-induced interstitial pneumonia (IP) in mice, so as to verify the effect of SH and CDP co-administration on interstitial pneumonia (IP) in mice. Synergistic effects of IP therapy.
[0043] 2.1 Experimental method
[0044] (1) Animal handling
[0045] C57BL / 6 mice (clean grade) were used in the experiment, weighing 20-24 g. The animals were housed in ordinary rat cages, maintained at room temperature of 24 ± 2 °C, light control ensured 12 hours of light and dark conditions, and fed with ordinary water.
[0046] The animals were randomly divided into 7 groups (8 animals in each group): control group, BLM-induced IP model group (BLM model group), IP model SH treatment group (BLM+SH group), IP model SH+CDP compound treatment group (SH: CDP) 3 kinds of compound prescriptions (respective...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com