Sarpogrelate hydrochloride sustained release preparation

A technology of sargrelate hydrochloride and sustained-release preparations, which is applied in the field of pharmaceutical preparations, can solve the problems of digestive tract irritation, poor compliance, and inconvenient medication for patients, and achieve the effect of simple preparation process

Inactive Publication Date: 2015-05-06
济南齐拓医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1) The in vitro release shows that the drug release reaches more than 80% after 30 minutes, and the emptying time of the stomach is about 2 hours. Therefore, most of the drugs are released in the stomach, and the local concentration is high, so it

Method used

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  • Sarpogrelate hydrochloride sustained release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Sagrelate Hydrochloride 50%

[0045] Polyvinyl Acetate Povidone Blend 40%

[0046] Microcrystalline Cellulose 8%

[0047] Povidone K30 1%

[0048] Magnesium Stearate 1%

Embodiment 2

[0050] Sagrelate Hydrochloride 40%

[0051] Polyvinyl Acetate Povidone Blend 50%

[0052] Microcrystalline Cellulose 8%

[0053] Povidone K30 1%

[0054] Magnesium Stearate 1%

Embodiment 3

[0056] Sagrelate Hydrochloride 40%

[0057] Polyvinyl Acetate Povidone Blend 40%

[0058] Microcrystalline Cellulose 18%

[0059] Povidone K30 1%

[0060]Magnesium Stearate 1%

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PUM

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Abstract

The invention belongs to the field of pharmaceutical preparations and discloses a sarpogrelate hydrochloride sustained release preparation. The sustained release preparation consists of sarpogrelate hydrochloride, a polyvinyl acetate povidone mixture and other auxiliary materials.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations. Background technique [0002] Sarpogrelate Hydrochloride (Sarpogrelate Hydrochloride), molecular formula: C 24 h 31 NO 6 HCl, with a molecular weight of 465.97, is a 5-HT receptor blocker developed by Mitsubishi Corporation of Japan. Its pharmacological effects include the following aspects: it has specific antagonistic effect on the 5-HT2 receptor of platelets and vascular smooth muscle; it inhibits platelet aggregation Effect; Antithrombotic effect; Inhibition of vasoconstriction; Improvement of microcirculation. [0003] Currently the only product on the market is sargrelate hydrochloride tablets, the trade name is Anbu Leke, and the specification is 100mg. It is clinically used to improve ischemic symptoms such as ulcer pain and cold sensation caused by chronic arterial occlusive disease. Usage and dosage: Adults take 100mg three times a day, orally after meals, but the dosage s...

Claims

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Application Information

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IPC IPC(8): A61K31/225A61K9/22A61K47/32A61P7/02A61P9/00
Inventor 王栋宋永亮王振沈华亭王润华
Owner 济南齐拓医药科技有限公司
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