Preparation method of 1, 4-dihydropyridine compound
A technology for dihydropyridine and compound, which is applied in the field of preparation of 1,4-dihydropyridine compounds, can solve problems such as environmental pollution, and achieve the effects of no environmental pollution, easy recycling and simple reaction operation.
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[0027] Example 1
[0028] A method for preparing 1,4-dihydropyridine compounds, wherein the structural formula of the 1,4-dihydropyridine compounds is as follows:
[0029]
[0030] Where the substituent R is 3-OCH 3 -4-OH group;
[0031] The above-mentioned preparation method of 1,4-dihydropyridine compounds, the reaction equation of the synthesis process is as follows:
[0032] That is, aromatic aldehydes, ethyl acetoacetate and ammonium acetate are reacted for 3-4 hours in the presence of the catalyst, namely the ionic liquid SiPIPPWO, at a temperature of 80℃. After the reaction is completed, cool to room temperature, add ethyl acetate, and filter to remove the catalyst, the ionic liquid SiPIPPWO , The filtrate is rotary evaporated to remove the solvent to obtain a crude product, and then recrystallized with 95% ethanol to obtain 1,4-dihydropyridine compounds;
[0033] The aromatic aldehyde is 3-methoxy-4-hydroxybenzaldehyde;
[0034] The aromatic aldehyde, ethyl acetoacetate and...
Example Embodiment
[0047] Example 2
[0048] A method for preparing 1,4-dihydropyridine compounds, the structural formula of the 1,4-dihydropyridine compounds is as follows:
[0049]
[0050] Wherein the substituent R is 3,4-OCH 2 O base;
[0051] The above-mentioned preparation method of 1,4-dihydropyridine compounds, the reaction equation of the synthesis process is as follows:
[0052] That is, aromatic aldehydes, ethyl acetoacetate and ammonium acetate are reacted for 3-4 hours in the presence of the catalyst, namely the ionic liquid SiPIPPWO, at a temperature of 80℃. After the reaction is completed, cool to room temperature, add ethyl acetate, and filter to remove the catalyst, the ionic liquid SiPIPPWO , The filtrate is rotary evaporated to remove the solvent to obtain a crude product, and then recrystallized with 95% ethanol to obtain 1,4-dihydropyridine compounds;
[0053] The aromatic aldehyde is 3,4-dioxymethylene benzaldehyde;
[0054] The aromatic aldehyde, ethyl acetoacetate and ammonium...
Example Embodiment
[0066] Example 3
[0067] A method for preparing 1,4-dihydropyridine compounds, the structural formula of the 1,4-dihydropyridine compounds is as follows:
[0068]
[0069] Wherein the substituent R is a -H group;
[0070] The above-mentioned preparation method of 1,4-dihydropyridine compounds, the reaction equation of the synthesis process is as follows:
[0071] That is, aromatic aldehydes, ethyl acetoacetate and ammonium acetate are reacted for 3-4 hours in the presence of the catalyst, namely the ionic liquid SiPIPPWO, at a temperature of 80℃. After the reaction is completed, cool to room temperature, add ethyl acetate, and filter to remove the catalyst, the ionic liquid SiPIPPWO , The filtrate is rotary evaporated to remove the solvent to obtain a crude product, and then recrystallized with 95% ethanol to obtain 1,4-dihydropyridine compounds;
[0072] The aromatic aldehyde is benzaldehyde;
[0073] The aromatic aldehyde, ethyl acetoacetate and ammonium acetate used in the abov...
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