Tacrolimus eye drop for treatment of dry eyes

A technology of tacrolimus and dry eye, which is applied in the field of treatment and can solve problems such as minor side effects

Inactive Publication Date: 2014-09-17
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, cyclosporine A, a drug of the same class as tacrolimus, has been approved by the US FDA for the treatment of dry eye. Compared with cyclosporine A, tacrolimus has a stronger a...

Method used

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  • Tacrolimus eye drop for treatment of dry eyes
  • Tacrolimus eye drop for treatment of dry eyes
  • Tacrolimus eye drop for treatment of dry eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Prepare tacrolimus with a concentration of 0.02%-0.03%.

[0012] Select 30 CBA / J mice and inject botulinum toxin (20mU / 50mL) into the lacrimal gland to induce mouse dry eye model. After 3 days of induction of the dry eye model, 30 mice were randomly divided into two groups. One group was given eye drops of normal saline four times a day as the control group, and the other group was given 0.02% to 0.03% tacrolimus eye drops , four times a day, as the experimental group, the experiment was carried out for one month. Ocular surface dry eye status was assessed every 7 days. One month later, the ocular surface fluorescein sodium staining score showed that the dry eye condition was significantly improved after the application of tacrolimus.

[0013] schedule

[0014] None.

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Abstract

The invention relates to a novel treatment method for dry eyes, i.e. treatment of dry eyes by tacrolimus with a concentration of 0.02%-0.03%. Directed at the current situation of clinical absence of effective methods for treatment of dry eyes, the invention aims to provide an effective measure with low side effect to treat dry eyes. Specifically, tacrolimus with a concentration of 0.02%-0.03% is applied four times per day for one month continuously so as to treat chronic non-sjogren syndrome related dry eyes.

Description

field of invention [0001] The patent of the present invention relates to a treatment method, specifically, local application of about 0.02% to 0.03% tacrolimus to treat dry eye Background of the invention [0002] The latest research shows that tacrolimus has a significant anti-inflammatory effect, and inflammation plays an important role in the pathogenesis of the eye. In addition, cyclosporine A, a drug of the same class as tacrolimus, has been approved by the US FDA for the treatment of dry eye. Compared with cyclosporine A, tacrolimus has a stronger anti-inflammatory effect and has Minor side effects, there is still no report on the treatment of dry eye with tacrolimus, so it is considered to be used in the treatment of dry eye. Contents of the invention [0003] The problem to be solved in the patent of the present invention is to provide a dry eye treatment plan with less side effects and significant curative effect in view of the current situation that there is no ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/436A61P27/02A61P29/00
Inventor 周世有
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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